Knowledge Management System of Kunming Institute of Botany,CAS
| Structures/cytotoxicity/selectivity relationship of natural steroidal saponins against GSCs and primary mechanism of tribulosaponin A | |
Dai,Zhi; Liu,Hui; Wang,Bei; Yang,Dong; Zhu,Yan-Yan; Yan,Huan; Zhu,Pei-Feng; Liu,Ya-Ping; Chen,Hui-Cheng; Zhao,Yun-li; Zhao,Li-Xing; Zhao,Xu-Dong; Liu,Hai-Yang ; Luo,Xiao-Dong
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| 2021 | |
| Source Publication | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
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| ISSN | 0223-5234 |
| Volume | 210Pages:113068 |
| Abstract | Glioblastoma multiform (GBM) is the highly aggressive brain tumor with poor prognosis. Glioma stem cells (GSCs), small population of cancer cells that exist in GBM tissues, resistant to chemotherapy and radiotherapy and usually driving GBM recurrence, have been developed as effective therapeutic target. Steroidal saponins are one of important resources for anti-tumor agent and may be benefited to selectively clear GSCs. In this report, total of 97 natural steroidal saponins were investigated the relationship among structures/cytotoxicity/selectivity against GSCs, glioma cell lines and human untransformed cells, and revealed that tribulosaponin A was the most potent compound. Further investigation suggested that tribulosaponin A up-regulated the expression of NCF1 and NOX1 to accumulate ROS for triggering apoptosis in GSCs, but not in untransformed cells, and it was further supported by the assay that N-acetyl-L-cysteine (NAC) clearing ROS delayed GSCs apoptosis. Besides, tribulosaponin A damaged GSCs recapturing tumor spheres formation. (C) 2020 Elsevier Masson SAS. All rights reserved. |
| Keyword | Steroidal saponins Structure-activity relationship Tribulosaponin A Glioma stem cells ROS SMALL MOLECULES CARDIAC-ARREST STEM-CELL IDENTIFICATION THERAPY BRAIN OPPORTUNITIES GLIOMA TUMORS NOX2 |
| DOI | 10.1016/j.ejmech.2020.113068 |
| WOS ID | WOS:000604903800047 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/73417 |
| Collection | 中国科学院昆明植物研究所 |
| Affiliation | 1.[Dai, Zhi 2.Zhu, Yan-Yan 3.Chen, Hui-Cheng 4.Zhao, Yun-li 5.Zhao, Li-Xing 6.Yunnan Univ, Yunnan Prov Ctr Res & Dev Nat Prod, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource,Minist Educ, Kunming 650091, Yunnan, Peoples R China 7.[Liu, Hui 8.Wang, Bei 9.Yan, Huan 10.Zhu, Pei-Feng 11.Liu, Ya-Ping 12.Liu, Hai-Yang 13.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 14.[Yang, Dong 15.Sichuan Univ, State Key Lab Biotherapy & Canc Ctr, Natl Clin Res Ctr Geriatr,West China Hosp, Lab Anim Tumor Models,Frontiers Sci Ctr Dis Relat, Chengdu 610041, Sichuan, Peoples R China |
| Recommended Citation GB/T 7714 | Dai,Zhi,Liu,Hui,Wang,Bei,et al. Structures/cytotoxicity/selectivity relationship of natural steroidal saponins against GSCs and primary mechanism of tribulosaponin A[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2021,210:113068. |
| APA | Dai,Zhi.,Liu,Hui.,Wang,Bei.,Yang,Dong.,Zhu,Yan-Yan.,...&Luo,Xiao-Dong.(2021).Structures/cytotoxicity/selectivity relationship of natural steroidal saponins against GSCs and primary mechanism of tribulosaponin A.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,210,113068. |
| MLA | Dai,Zhi,et al."Structures/cytotoxicity/selectivity relationship of natural steroidal saponins against GSCs and primary mechanism of tribulosaponin A".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 210(2021):113068. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| 110-H09-136.pdf（2630KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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