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Structures/cytotoxicity/selectivity relationship of natural steroidal saponins against GSCs and primary mechanism of tribulosaponin A
Dai,Zhi; Liu,Hui; Wang,Bei; Yang,Dong; Zhu,Yan-Yan; Yan,Huan; Zhu,Pei-Feng; Liu,Ya-Ping; Chen,Hui-Cheng; Zhao,Yun-li; Zhao,Li-Xing; Zhao,Xu-Dong; Liu,Hai-Yang; Luo,Xiao-Dong
2021
Source PublicationEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
ISSN0223-5234
Volume210Pages:113068
AbstractGlioblastoma multiform (GBM) is the highly aggressive brain tumor with poor prognosis. Glioma stem cells (GSCs), small population of cancer cells that exist in GBM tissues, resistant to chemotherapy and radiotherapy and usually driving GBM recurrence, have been developed as effective therapeutic target. Steroidal saponins are one of important resources for anti-tumor agent and may be benefited to selectively clear GSCs. In this report, total of 97 natural steroidal saponins were investigated the relationship among structures/cytotoxicity/selectivity against GSCs, glioma cell lines and human untransformed cells, and revealed that tribulosaponin A was the most potent compound. Further investigation suggested that tribulosaponin A up-regulated the expression of NCF1 and NOX1 to accumulate ROS for triggering apoptosis in GSCs, but not in untransformed cells, and it was further supported by the assay that N-acetyl-L-cysteine (NAC) clearing ROS delayed GSCs apoptosis. Besides, tribulosaponin A damaged GSCs recapturing tumor spheres formation. (C) 2020 Elsevier Masson SAS. All rights reserved.
KeywordSteroidal saponins Structure-activity relationship Tribulosaponin A Glioma stem cells ROS SMALL MOLECULES CARDIAC-ARREST STEM-CELL IDENTIFICATION THERAPY BRAIN OPPORTUNITIES GLIOMA TUMORS NOX2
DOI10.1016/j.ejmech.2020.113068
WOS IDWOS:000604903800047
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/73417
Collection中国科学院昆明植物研究所
Affiliation1.[Dai, Zhi
2.Zhu, Yan-Yan
3.Chen, Hui-Cheng
4.Zhao, Yun-li
5.Zhao, Li-Xing
6.Yunnan Univ, Yunnan Prov Ctr Res & Dev Nat Prod, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource,Minist Educ, Kunming 650091, Yunnan, Peoples R China
7.[Liu, Hui
8.Wang, Bei
9.Yan, Huan
10.Zhu, Pei-Feng
11.Liu, Ya-Ping
12.Liu, Hai-Yang
13.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
14.[Yang, Dong
15.Sichuan Univ, State Key Lab Biotherapy & Canc Ctr, Natl Clin Res Ctr Geriatr,West China Hosp, Lab Anim Tumor Models,Frontiers Sci Ctr Dis Relat, Chengdu 610041, Sichuan, Peoples R China
Recommended Citation
GB/T 7714
Dai,Zhi,Liu,Hui,Wang,Bei,et al. Structures/cytotoxicity/selectivity relationship of natural steroidal saponins against GSCs and primary mechanism of tribulosaponin A[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2021,210:113068.
APA Dai,Zhi.,Liu,Hui.,Wang,Bei.,Yang,Dong.,Zhu,Yan-Yan.,...&Luo,Xiao-Dong.(2021).Structures/cytotoxicity/selectivity relationship of natural steroidal saponins against GSCs and primary mechanism of tribulosaponin A.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,210,113068.
MLA Dai,Zhi,et al."Structures/cytotoxicity/selectivity relationship of natural steroidal saponins against GSCs and primary mechanism of tribulosaponin A".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 210(2021):113068.
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