Structures/cytotoxicity/selectivity relationship of natural steroidal saponins against GSCs and primary mechanism of tribulosaponin A

doi:10.1016/j.ejmech.2020.113068

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	Structures/cytotoxicity/selectivity relationship of natural steroidal saponins against GSCs and primary mechanism of tribulosaponin A
	Dai,Zhi ; Liu,Hui ; Wang,Bei ; Yang,Dong ; Zhu,Yan-Yan ; Yan,Huan ; Zhu,Pei-Feng ; Liu,Ya-Ping ; Chen,Hui-Cheng ; Zhao,Yun-li ; Zhao,Li-Xing ; Zhao,Xu-Dong ; Liu,Hai-Yang; Luo,Xiao-Dong
	2021
发表期刊	EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
ISSN	0223-5234
卷号	210 页码:113068
摘要	Glioblastoma multiform (GBM) is the highly aggressive brain tumor with poor prognosis. Glioma stem cells (GSCs), small population of cancer cells that exist in GBM tissues, resistant to chemotherapy and radiotherapy and usually driving GBM recurrence, have been developed as effective therapeutic target. Steroidal saponins are one of important resources for anti-tumor agent and may be benefited to selectively clear GSCs. In this report, total of 97 natural steroidal saponins were investigated the relationship among structures/cytotoxicity/selectivity against GSCs, glioma cell lines and human untransformed cells, and revealed that tribulosaponin A was the most potent compound. Further investigation suggested that tribulosaponin A up-regulated the expression of NCF1 and NOX1 to accumulate ROS for triggering apoptosis in GSCs, but not in untransformed cells, and it was further supported by the assay that N-acetyl-L-cysteine (NAC) clearing ROS delayed GSCs apoptosis. Besides, tribulosaponin A damaged GSCs recapturing tumor spheres formation. (C) 2020 Elsevier Masson SAS. All rights reserved.
关键词	Steroidal saponins Structure-activity relationship Tribulosaponin A Glioma stem cells ROS SMALL MOLECULES CARDIAC-ARREST STEM-CELL IDENTIFICATION THERAPY BRAIN OPPORTUNITIES GLIOMA TUMORS NOX2
DOI	10.1016/j.ejmech.2020.113068
WOS记录号	WOS:000604903800047
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73417
专题	中国科学院昆明植物研究所
作者单位	1.[Dai, Zhi 2.Zhu, Yan-Yan 3.Chen, Hui-Cheng 4.Zhao, Yun-li 5.Zhao, Li-Xing 6.Yunnan Univ, Yunnan Prov Ctr Res & Dev Nat Prod, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource,Minist Educ, Kunming 650091, Yunnan, Peoples R China 7.[Liu, Hui 8.Wang, Bei 9.Yan, Huan 10.Zhu, Pei-Feng 11.Liu, Ya-Ping 12.Liu, Hai-Yang 13.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 14.[Yang, Dong 15.Sichuan Univ, State Key Lab Biotherapy & Canc Ctr, Natl Clin Res Ctr Geriatr,West China Hosp, Lab Anim Tumor Models,Frontiers Sci Ctr Dis Relat, Chengdu 610041, Sichuan, Peoples R China
推荐引用方式 GB/T 7714	Dai,Zhi,Liu,Hui,Wang,Bei,et al. Structures/cytotoxicity/selectivity relationship of natural steroidal saponins against GSCs and primary mechanism of tribulosaponin A[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2021,210:113068.
APA	Dai,Zhi.,Liu,Hui.,Wang,Bei.,Yang,Dong.,Zhu,Yan-Yan.,...&Luo,Xiao-Dong.(2021).Structures/cytotoxicity/selectivity relationship of natural steroidal saponins against GSCs and primary mechanism of tribulosaponin A.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,210,113068.
MLA	Dai,Zhi,et al."Structures/cytotoxicity/selectivity relationship of natural steroidal saponins against GSCs and primary mechanism of tribulosaponin A".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 210(2021):113068.

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