Isolation and identification of hemostatic steroidal glycosides from Ypsilandra thibetica

doi:10.1016/j.bioorg.2022.106268

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	Isolation and identification of hemostatic steroidal glycosides from Ypsilandra thibetica
	Ma,Wen-Yi; Xie,Jing; Yu,Ling-Ling; Zhang,Shi-Juan; Ni,Wei; Yan,Huan; Liu,Hai-Yang
	2023
发表期刊	BIOORGANIC CHEMISTRY
ISSN	1090-2120
卷号	130 页码:106268
摘要	The phytoconstituents of the fraction with hemostatic activity of the 70% aqueous ethanol extract of Ypsilandra thibetica Franch. were investigated. As a result, fourteen previously unreported spirostanol saponins, ypsilan-drosides Z1-Z14, and nine known analogues were isolated and characterized by MS, NMR, and chemical methods. Among them, ypsilandrosides Z1-Z4 (1-4) have a rare 12-O-beta-D-glucopyranosyl group, while ypsi-landrosides Z5-Z8 (5-8) possess a rare double bond between C-4 and C-5, and a hydroxyl or carbonyl located at the C-6. All isolates were further tested for their hemostatic activity. The results suggested that five spirostanol tetraglycosides show favorable inducing platelet aggregation activities. Among them, ypsilandroside G (16) displayed significant inducing platelet aggregation activity with an EC50 value of 57.17 mu M. Furthermore, the preliminary structure-activity relationship of these spirostanol glycosides' hemostatic activity was discussed.
关键词	Ypsilandra thibetica Steroidal saponins Ypsilandrosides Z1-Z14 Hemostatic activity Structure-activity relationship SPIROSTANE GLYCOSIDES NMR-SPECTROSCOPY AGGREGATION SAPOGENINS SAPONINS
学科领域	Biochemistry & Molecular Biology ; Chemistry
DOI	10.1016/j.bioorg.2022.106268
收录类别	SCI
WOS记录号	WOS:000926474500006
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75480
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Ma,Wen-Yi,Xie,Jing,Yu,Ling-Ling,et al. Isolation and identification of hemostatic steroidal glycosides from Ypsilandra thibetica[J]. BIOORGANIC CHEMISTRY,2023,130:106268.
APA	Ma,Wen-Yi.,Xie,Jing.,Yu,Ling-Ling.,Zhang,Shi-Juan.,Ni,Wei.,...&Liu,Hai-Yang.(2023).Isolation and identification of hemostatic steroidal glycosides from Ypsilandra thibetica.BIOORGANIC CHEMISTRY,130,106268.
MLA	Ma,Wen-Yi,et al."Isolation and identification of hemostatic steroidal glycosides from Ypsilandra thibetica".BIOORGANIC CHEMISTRY 130(2023):106268.

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