| Cytotoxic steroidal saponins from Trillium kamtschaticum | |
Qin, Xu-Jie1,3 ; Si, Yong-Ai1,3; Chen, Yu1,3; Liu, Hui1,3,4; Ni, Wei1,3; Yan, Huan1,3; Shu, Tong1,3,4; Ji, Yun-Heng2; Liu, Hai-Yang1,3
| |
| 2017-06-01 | |
| 发表期刊 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 卷号 | 27页码:2267-2273 |
| 摘要 | Eight new steroidal saponins, trillikamtosides K-R (1-8), along with three known analogues, were isolated from the whole plants of Trillium kamtschaticum. Their structures were unambiguously established by interpretation of spectroscopic data (MS and NMR) and chemical methods. Compound 1 had a rare aglycone featuring a skeleton of 16-oxaandrost-5-en-3-01-17-one, which was reported for the first time. The isolated saponins were tested for cytotoxicities against HCT116 cells, and trillikamtoside R (8) was found to show the most cytotoxic effect with an IC50 value of 4.92 mu M. (C) 2017 Elsevier Ltd. All rights reserved. |
| 关键词 | Trillium Kamtschaticum Liliaceae Steroidal Saponins Cytotoxicity |
| DOI | 10.1016/j.bmcl.2017.04.057 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000402023800003 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/51360 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, Key Lab Plant Biodivers & Biogeog East Asia, Kunming 650201, Peoples R China 3.Yunnan Key Lab Nat Med Chem, Kunming 650201, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qin, Xu-Jie,Si, Yong-Ai,Chen, Yu,et al. Cytotoxic steroidal saponins from Trillium kamtschaticum[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2017,27:2267-2273. |
| APA | Qin, Xu-Jie.,Si, Yong-Ai.,Chen, Yu.,Liu, Hui.,Ni, Wei.,...&Liu, Hai-Yang.(2017).Cytotoxic steroidal saponins from Trillium kamtschaticum.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,27,2267-2273. |
| MLA | Qin, Xu-Jie,et al."Cytotoxic steroidal saponins from Trillium kamtschaticum".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 27(2017):2267-2273. |
| 条目包含的文件 | 下载所有文件 | |||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| qin12017.pdf（529KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论