Cytotoxic steroidal saponins from Trillium kamtschaticum
Qin, Xu-Jie1,3; Si, Yong-Ai1,3; Chen, Yu1,3; Liu, Hui1,3,4; Ni, Wei1,3; Yan, Huan1,3; Shu, Tong1,3,4; Ji, Yun-Heng2; Liu, Hai-Yang1,3
2017-06-01
Source PublicationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume27Pages:2267-2273
AbstractEight new steroidal saponins, trillikamtosides K-R (1-8), along with three known analogues, were isolated from the whole plants of Trillium kamtschaticum. Their structures were unambiguously established by interpretation of spectroscopic data (MS and NMR) and chemical methods. Compound 1 had a rare aglycone featuring a skeleton of 16-oxaandrost-5-en-3-01-17-one, which was reported for the first time. The isolated saponins were tested for cytotoxicities against HCT116 cells, and trillikamtoside R (8) was found to show the most cytotoxic effect with an IC50 value of 4.92 mu M. (C) 2017 Elsevier Ltd. All rights reserved.
KeywordTrillium Kamtschaticum Liliaceae Steroidal Saponins Cytotoxicity
DOI10.1016/j.bmcl.2017.04.057
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy ; Chemistry
WOS SubjectChemistry, Medicinal ; Chemistry, Organic
WOS IDWOS:000402023800003
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Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/51360
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Key Lab Plant Biodivers & Biogeog East Asia, Kunming 650201, Peoples R China
3.Yunnan Key Lab Nat Med Chem, Kunming 650201, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Qin, Xu-Jie,Si, Yong-Ai,Chen, Yu,et al. Cytotoxic steroidal saponins from Trillium kamtschaticum[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2017,27:2267-2273.
APA Qin, Xu-Jie.,Si, Yong-Ai.,Chen, Yu.,Liu, Hui.,Ni, Wei.,...&Liu, Hai-Yang.(2017).Cytotoxic steroidal saponins from Trillium kamtschaticum.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,27,2267-2273.
MLA Qin, Xu-Jie,et al."Cytotoxic steroidal saponins from Trillium kamtschaticum".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 27(2017):2267-2273.
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