Isolation, structural elucidation, and bioactivity of cholestane derivatives from Ypsilandra thibetica

doi:10.1039/d2nj04576a

KIB OpenIR

	Isolation, structural elucidation, and bioactivity of cholestane derivatives from Ypsilandra thibetica
	Xie, Jing; Zhang, Shi-Juan; Yue, Grace Gar-Lee; Yu, Ling-Ling; Liu, Hui; Ma, Wen-Yi; Yan, Huan; Ni, Wei; Lau, Clara Bik-San; Liu, Hai-Yang
	2022
发表期刊	NEW JOURNAL OF CHEMISTRY
卷号	47 期号:1 页码:324-332
摘要	Phytochemical investigation on the whole plant of Ypsilandra thibetica led to the isolation of five new cholestane derivatives. The structures of 1-5 were elucidated by comprehensive spectroscopic analyses of their data and chemical methods. The absolute configurations of compounds 1-3 were ambiguously assigned by single crystal X-ray diffraction analysis. Compound 1 is the first cholestane glycoside with two oxygen bridges between C-16/C-23 and C-18/C-23. Compound 2 is the first 23-spirocholestane derivative with a six-membered ring between C-24/C-23 of the aglycone moiety and C-1 & PRIME;/C-2 & PRIME; of the d-arabinose ligand, while compounds 3-5 are new 23-spirocholestane derivatives with a d-fucose ligand. The cytotoxic, anti-inflammatory, and anti-angiogenic activities of these isolated compounds were evaluated. Compound 5 showed anti-angiogenic activity in zebrafish embryos.
关键词	SPIROSTANE GLYCOSIDES STEROIDAL SAPONINS GROWTH
DOI	10.1039/d2nj04576a
收录类别	SCI
WOS记录号	WOS:000900709800001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/74662
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Xie, Jing,Zhang, Shi-Juan,Yue, Grace Gar-Lee,et al. Isolation, structural elucidation, and bioactivity of cholestane derivatives from Ypsilandra thibetica[J]. NEW JOURNAL OF CHEMISTRY,2022,47(1):324-332.
APA	Xie, Jing.,Zhang, Shi-Juan.,Yue, Grace Gar-Lee.,Yu, Ling-Ling.,Liu, Hui.,...&Liu, Hai-Yang.(2022).Isolation, structural elucidation, and bioactivity of cholestane derivatives from Ypsilandra thibetica.NEW JOURNAL OF CHEMISTRY,47(1),324-332.
MLA	Xie, Jing,et al."Isolation, structural elucidation, and bioactivity of cholestane derivatives from Ypsilandra thibetica".NEW JOURNAL OF CHEMISTRY 47.1(2022):324-332.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
10.1039_d2nj04576a.p（1693KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	浏览下载