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High throughput-screening of native herbal compounds identifies taccaoside A as a cytotoxic compound that mediates RAS signaling in cancer stem cells 期刊论文
PHYTOMEDICINE, 2023, 卷号: 108, 页码: 154492
作者:  Yang,Dong;  Dai,Zhi;  Zhu,Peifeng;  Wang,Gan;  Sun,Bin;  Li,Shirong;  Hao,Junjun;  Wang,Yifen;  Liu,Yaping;  Yu,Shuaishuai;  Lai,Ren;  Luo,Xiao-Dong;  Zhao,Xudong
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Natural product  Furostanol saponin  Taccaoside A  Cancer stem cell  RAS  STEROIDAL SAPONINS  NATURAL-PRODUCTS  PI3K/AKT  PROLIFERATION  MAINTENANCE  STATISTICS  MAPK/ERK  
Anticarin-beta shows a promising anti-osteosarcoma effect by specifically inhibiting CCT4 to impair proteostasis 期刊论文
ACTA PHARMACEUTICA SINICA B, 2022, 卷号: 12, 期号: 5, 页码: 2268-2279
作者:  Wang, Gan;  Zhang, Min;  Meng, Ping;  Long, Chengbo;  Luo, Xiaodong;  Yang, Xingwei;  Wang, Yunfei;  Zhang, Zhiye;  Mwangi, James;  Kamau, Peter Muiruri;  Dai, Zhi;  Ke, Zunfu;  Zhang, Yi;  Chen, Wenlin;  Zhao, Xudong;  Ge, Fei;  Lv, Qiumin;  Rong, Mingqiang;  Li, Dongsheng;  Jin, Yang;  Sheng, Xia;  Lai, Ren
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Proteostasis  CCT  TRiC  Osteosarcoma  STAT3  Anticarin-beta  PDX model  CYTOSOLIC CHAPERONIN  CANCER-CELLS  COMPLEX  EXPRESSION  SURVIVAL  PROTEIN  TUBULIN  GROWTH  
Prostaglandin E1 Is an Efficient Molecular Tool for Forest Leech Blood Sucking 期刊论文
FRONTIERS IN VETERINARY SCIENCE, 2021, 卷号: 7, 页码: 615915
作者:  Zheng,Fenshuang;  Zhang,Min;  Yang,Xingwei;  Wu,Feilong;  Wang,Gan;  Feng,Xingxing;  Ombati,Rose;  Zuo,Ruiling;  Yang,Canju;  Liu,Jun;  Lai,Ren;  Luo,Xiaodong;  Long,Chengbo
收藏  |  浏览/下载：335/0  |  提交时间：2022/04/02
leech  blood-sucking  prostaglandin E1  anticoagulant  Haemadipsa sylvestris  MEDICINAL LEECH  PGE1  INFLAMMATION  THERAPY  PAIN  E-1  
Dalbavancin binds ACE2 to block its interaction with SARS-CoV-2 spike protein and is effective in inhibiting SARS-CoV-2 infection in animal models 期刊论文
CELL RESEARCH, 2021, 卷号: 31, 期号: 1, 页码: 17-24
作者:  Wang,Gan;  Yang,Meng-Li;  Duan,Zi-Lei;  Liu,Feng-Liang;  Jin,Lin;  Long,Cheng-Bo;  Zhang,Min;  Tang,Xiao-Peng;  Xu,Ling;  Li,Ying-Chang;  Kamau,Peter Muiruri;  Yang,Lian;  Liu,Hong-Qi;  Xu,Jing-Wen;  Chen,Jie-Kai;  Zheng,Yong-Tang;  Peng,Xiao-Zhong;  Lai,Ren
收藏  |  浏览/下载：224/0  |  提交时间：2022/04/02
SARS  ENTRY  MERS  
Dalbavancin binds ACE2 to block its interaction with SARS-CoV-2 spike protein and is effective in inhibiting SARS-CoV-2 infection in animal models 期刊论文
CELL RESEARCH, 2020
作者:  Wang, Gan;  Yang, Meng-Li;  Duan, Zi-Lei;  Liu, Feng-Liang;  Jin, Lin;  Long, Cheng-Bo;  Zhang, Min;  Tang, Xiao-Peng;  Xu, Ling;  Li, Ying-Chang;  Kamau, Peter Muiruri;  Yang, Lian;  Liu, Hong-Qi;  Xu, Jing-Wen;  Chen, Jie-Kai;  Zheng, Yong-Tang;  Peng, Xiao-Zhong;  Lai, Ren
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Identification and Characterization of ShSPI, a Kazal-Type Elastase Inhibitor from the Venom of Scolopendra Hainanum 期刊论文
TOXINS, 2019, 卷号: 11, 期号: 12, 页码: 13
作者:  Luan, Ning;  Zhao, Qiyu;  Duan, Zilei;  Ji, Mengyao;  Xing, Meichen;  Zhu, Tengyu;  Mwangi, James;  Rong, Mingqiang;  Liu, Jiangxin;  Lai, Ren
浏览  |  Adobe PDF(2415Kb)  |  收藏  |  浏览/下载：359/54  |  提交时间：2020/03/18
centipede  kazal-type inhibitor  human neutrophils elastase  ShSPI  
Hybrid isoquinolines from Thalictrum foetidum: a new type of aporphine inhibiting Staphylococcus aureus by combined mechanisms 期刊论文
ORGANIC CHEMISTRY FRONTIERS, 2019, 卷号: 6, 期号: 19, 页码: 3428-3434
作者:  Ding, Cai-Feng;  Zhang, Rong-Ping;  Yu, Hao-Fei;  Yang, Jing;  Qin, Xu-Jie;  Dai, Zhi;  Liu, Ya-Ping;  Lu, Qiu-Min;  Lai, Ren;  Luo, Xiao-Dong
浏览  |  Adobe PDF(2565Kb)  |  收藏  |  浏览/下载：407/53  |  提交时间：2019/11/07
Direct and indirect effects of climate on richness drive the latitudinal diversity gradient in forest trees 期刊论文
ECOLOGY LETTERS, 2019, 卷号: 22, 期号: 2, 页码: 245-255
作者:  Chu, Chengjin;  Lutz, James A.;  Kral, Kamil;  Vrska, Tomas;  Yin, Xue;  Myers, Jonathan A.;  Abiem, Iveren;  Alonso, Alfonso;  Bourg, Norm;  Burslem, David F. R. P.;  Cao, Min;  Chapman, Hazel;  Condit, Richard;  Fang, Suqin;  Fischer, Gunter A.;  Gao, Lianming;  Hao, Zhanqin;  Hau, Billy C. H.;  He, Qing;  Hector, Andrew;  Hubbell, Stephen P.;  Jiang, Mingxi;  Jin, Guangze;  Kenfack, David;  Lai, Jiangshan;  Li, Buhang;  Li, Xiankun;  Li, Yide;  Lian, Juyu;  Lin, Luxiang;  Liu, Yankun;  Liu, Yu;  Luo, Yahuang;  Ma, Keping;  McShea, William;  Memiaghe, Herve;  Mi, Xiangcheng;  Ni, Ming;  O'Brien, Michael J.;  de Oliveira, Alexandre A.;  Orwig, David A.;  Parker, Geoffrey G.;  Qiao, Xiujuan;  Ren, Haibao;  Reynolds, Glen;  Sang, Weiguo;  Shen, Guochun;  Su, Zhiyao;  Sui, Xinghua;  Sun, I-Fang;  Tian, Songyan;  Wang, Bin;  Wang, Xihua;  Wang, Xugao;  Wang, Youshi;  Weiblen, George D.;  Wen, Shujun;  Xi, Nianxun;  Xiang, Wusheng;  Xu, Han;  Xu, Kun;  Ye, Wanhui;  Zhang, Bingwei;  Zhang, Jiaxin;  Zhang, Xiaotong;  Zhang, Yingming;  Zhu, Kai;  Zimmerman, Jess;  Storch, David;  Baltzer, Jennifer L.;  Anderson-Teixeira, Kristina J.;  Mittelbach, Gary G.;  He, Fangliang
浏览  |  Adobe PDF(793Kb)  |  收藏  |  浏览/下载：2703/274  |  提交时间：2019/03/18
Climate Tolerance Hypothesis  Ctfs-forestgeo  Latitudinal Diversity Gradient  More-individuals Hypothesis  Species-energy Relationship  Structural Equation Modelling  
Novel Sodium Channel Inhibitor From Leeches 期刊论文
FRONTIERS IN PHARMACOLOGY, 2018, 卷号: 9, 页码: 186
作者:  Wang, Gan;  Long, Chengbo;  Liu, Weihui;  Xu, Cheng;  Zhang, Min;  Li, Qiong;  Lu, Qiumin;  Meng, Ping;  Li, Dongsheng;  Rong, Mingqiang;  Sun, Zhaohui;  Luo, Xiaodong;  Lai, Ren
浏览  |  Adobe PDF(1661Kb)  |  收藏  |  浏览/下载：450/86  |  提交时间：2018/05/08
Leech Therapy  Blood-sucking  Sodium Channel  Pain  Analgesia  
Phenolic acids isolated from the fungus Schizophyllum commune exert analgesic activity by inhibiting voltage-gated sodium channels 期刊论文
CHINESE JOURNAL OF NATURAL MEDICINES, 2016, 卷号: 14, 期号: 9, 页码: 661-670
作者:  Yao Hui-Min;  Wang Gan;  Liu Ya-Ping;  Rong Ming-Qiang;  Shen Chuan-Bin;  Yan Xiu-Wen;  Luo Xiao-Dong;  Lai Ren
浏览  |  Adobe PDF(1343Kb)  |  收藏  |  浏览/下载：401/109  |  提交时间：2017/01/05
Schizophyllum Commune  Sodium Channel  Phenolic Acids  Painf