Hybrid isoquinolines from Thalictrum foetidum: a new type of aporphine inhibiting Staphylococcus aureus by combined mechanisms
Ding, Cai-Feng1,6; Zhang, Rong-Ping4,5; Yu, Hao-Fei2,4,5; Yang, Jing1; Qin, Xu-Jie1; Dai, Zhi1; Liu, Ya-Ping1; Lu, Qiu-Min3; Lai, Ren3; Luo, Xiao-Dong1,2
Corresponding AuthorLai, Ren(rlai@mail.kib.ac.cn) ; Luo, Xiao-Dong(xdluo@mail.kib.ac.cn)
2019-10-07
Source PublicationORGANIC CHEMISTRY FRONTIERS
ISSN2052-4129
Volume6Issue:19Pages:3428-3434
AbstractThalfoetines A-D (1-4), unique hybrid aporphine alkaloids with a C-7 aromatic unit formed by a new C-C bond linking two building blocks, were isolated from Thalictrum foetidum. Their structures were elucidated by extensive spectroscopic and computational analysis. They inhibited bacteria significantly, and compound 1 damaged the cell structure of Staphylococcus aureus and inhibited its DNA synthesis.
DOI10.1039/c9qo00737g
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000487508600017
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/69471
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorLai, Ren; Luo, Xiao-Dong
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, Key Lab Phytochem & Plant Resources West China, Kunming 650201, Yunnan, Peoples R China
2.Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource, Minist Educ & Yunnan Prov, Kunming 650091, Yunnan, Peoples R China
3.Chinese Acad Sci & Yunnan Prov, Key Lab Anim Models & Human Dis Mech, Kunming Inst Zool, Kunming 650223, Yunnan, Peoples R China
4.Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Yunnan, Peoples R China
5.Kunming Med Univ, Yunnan Key Lab Pharmacologyf Nat Prod, Kunming 650500, Yunnan, Peoples R China
6.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Ding, Cai-Feng,Zhang, Rong-Ping,Yu, Hao-Fei,et al. Hybrid isoquinolines from Thalictrum foetidum: a new type of aporphine inhibiting Staphylococcus aureus by combined mechanisms[J]. ORGANIC CHEMISTRY FRONTIERS,2019,6(19):3428-3434.
APA Ding, Cai-Feng.,Zhang, Rong-Ping.,Yu, Hao-Fei.,Yang, Jing.,Qin, Xu-Jie.,...&Luo, Xiao-Dong.(2019).Hybrid isoquinolines from Thalictrum foetidum: a new type of aporphine inhibiting Staphylococcus aureus by combined mechanisms.ORGANIC CHEMISTRY FRONTIERS,6(19),3428-3434.
MLA Ding, Cai-Feng,et al."Hybrid isoquinolines from Thalictrum foetidum: a new type of aporphine inhibiting Staphylococcus aureus by combined mechanisms".ORGANIC CHEMISTRY FRONTIERS 6.19(2019):3428-3434.
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