Phenolic acids isolated from the fungus Schizophyllum commune exert analgesic activity by inhibiting voltage-gated sodium channels
Yao Hui-Min1; Wang Gan1; Liu Ya-Ping3; Rong Ming-Qiang2; Shen Chuan-Bin2; Yan Xiu-Wen1; Luo Xiao-Dong3; Lai Ren1,2
2016-09-01
Source PublicationCHINESE JOURNAL OF NATURAL MEDICINES
Volume14Issue:9Pages:661-670
AbstractThe present study was designed to search for compounds with analgesic activity from the Schizophyllum commune (SC), which is widely consumed as edible and medicinal mushroom world. Thin layer chromatography (TLC), tosilica gel column chromatography, sephadex LH 20, and reverse-phase high performance liquid chromatography (RP-HPLC) were used to isolate and purify compounds from SC. Structural analysis of the isolated compounds was based on nuclear magnetic resonance (NMR). The effects of these compounds on voltage-gated sodium (Na-V) channels were evaluated using patch clamp. The analgesic activity of these compounds was tested in two types of mouse pain models induced by noxious chemicals. Five phenolic acids identified from SC extracts in the present study included vanillic acid, m-hydroxybenzoic acid, o-hydroxybenzeneacetic acid, 3-hydroxy-5-methybenzoic acid, and p-hydroxybenzoic acid. They inhibited the activity of both tetrodotoxin-resistant (TTX-r) and tetrodotoxin-sensitive (TTX-s) NaV channels. All the compounds showed low selectivity on NaV channel subtypes. After intraperitoneal injection, three compounds of these compounds exerted analgesic activity in mice. In conclusion, phenolic acids identified in SC demonstrated analgesic activity, facilitating the mechanistic studies of SC in the treatment of neurasthenia.
KeywordSchizophyllum Commune Sodium Channel Phenolic Acids Painf
Indexed BySCI
Language英语
WOS IDWOS:000386599300003
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Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/33656
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Nanjing Agr Univ, Coll Life Sci, Nanjing 210095, Jiangsu, Peoples R China
2.Chinese Acad Sci & Yunnan Prov, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
Recommended Citation
GB/T 7714
Yao Hui-Min,Wang Gan,Liu Ya-Ping,et al. Phenolic acids isolated from the fungus Schizophyllum commune exert analgesic activity by inhibiting voltage-gated sodium channels[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2016,14(9):661-670.
APA Yao Hui-Min.,Wang Gan.,Liu Ya-Ping.,Rong Ming-Qiang.,Shen Chuan-Bin.,...&Lai Ren.(2016).Phenolic acids isolated from the fungus Schizophyllum commune exert analgesic activity by inhibiting voltage-gated sodium channels.CHINESE JOURNAL OF NATURAL MEDICINES,14(9),661-670.
MLA Yao Hui-Min,et al."Phenolic acids isolated from the fungus Schizophyllum commune exert analgesic activity by inhibiting voltage-gated sodium channels".CHINESE JOURNAL OF NATURAL MEDICINES 14.9(2016):661-670.
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