| Identification and Characterization of ShSPI, a Kazal-Type Elastase Inhibitor from the Venom of Scolopendra Hainanum | |
| Luan, Ning1; Zhao, Qiyu2; Duan, Zilei2; Ji, Mengyao1; Xing, Meichen1; Zhu, Tengyu1; Mwangi, James2; Rong, Mingqiang3; Liu, Jiangxin4; Lai, Ren1,2,5 | |
| 通讯作者 | Rong, Mingqiang(rongmq@hunnu.edu.cn) ; Liu, Jiangxin(liujiangxin@mail.kib.ac.cn) ; Lai, Ren(rlai@mail.kiz.ac.cn) |
| 2019-12-01 | |
| 发表期刊 | TOXINS
 |
| 卷号 | 11期号:12页码:13 |
| 摘要 | Elastase is a globular glycoprotein and belongs to the chymotrypsin family. It is involved in several inflammatory cascades on the basis of cleaving the important connective tissue protein elastin, and is strictly regulated to a balance by several endogenous inhibitors. When elastase and its inhibitors are out of balance, severe diseases will develop, especially those involved in the cardiopulmonary system. Much attention has been attracted in seeking innovative elastase inhibitors and various advancements have been taken on clinical trials of these inhibitors. Natural functional peptides from venomous animals have been shown to have anti-protease properties. Here, we identified a kazal-type serine protease inhibitor named ShSPI from the cDNA library of the venom glands of Scolopendra hainanum. ShSPI showed significant inhibitory effects on porcine pancreatic elastase and human neutrophils elastase with Ki values of 225.83 +/- 20 nM and 12.61 +/- 2 nM, respectively. Together, our results suggest that ShSPI may be an excellent candidate to develop a drug for cardiopulmonary diseases. |
| 关键词 | centipede kazal-type inhibitor human neutrophils elastase ShSPI |
| DOI | 10.3390/toxins11120708 |
| 收录类别 | SCI ; SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000507337800031 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/70620 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Rong, Mingqiang; Liu, Jiangxin; Lai, Ren |
| 作者单位 | 1.Nanjing Agr Univ, Dept Zool, Coll Life Sci, Nanjing 210095, Peoples R China 2.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Key Lab Bioact Peptides Yunnan Prov, Kunming 650223, Yunnan, Peoples R China 3.Hunan Normal Univ, Coll Life Sci, Natl Local Joint Engn Lab Anim Peptide Drug Dev, Changsha 410081, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 5.Chinese Acad Sci, Kunming Inst Zool, Sino African Joint Res Ctr, Kunming 650223, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Luan, Ning,Zhao, Qiyu,Duan, Zilei,et al. Identification and Characterization of ShSPI, a Kazal-Type Elastase Inhibitor from the Venom of Scolopendra Hainanum[J]. TOXINS,2019,11(12):13. |
| APA | Luan, Ning.,Zhao, Qiyu.,Duan, Zilei.,Ji, Mengyao.,Xing, Meichen.,...&Lai, Ren.(2019).Identification and Characterization of ShSPI, a Kazal-Type Elastase Inhibitor from the Venom of Scolopendra Hainanum.TOXINS,11(12),13. |
| MLA | Luan, Ning,et al."Identification and Characterization of ShSPI, a Kazal-Type Elastase Inhibitor from the Venom of Scolopendra Hainanum".TOXINS 11.12(2019):13. |
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