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ABT-263 enhances sorafenib-induced apoptosis associated with Akt activity and the expression of Bax and p21 (CIP1/WAF1) in human cancer cells1 期刊论文
出版物, 3111, 期号: 0, 页码: 1-35
Authors:  Jingru Li;  Yicheng Chen;  Jiali Wan;  Xin Liu;  Chunrong Yu;  Wenhua Li
Adobe PDF(1198Kb)  |  Favorite  |  View/Download:265/1  |  Submit date:2017/07/24
Abt-263  Sorafenib  Combination Therapy  Cancer  
Structural and mechanistic basis of penicillin-bindingprotein inhibition by lactivicins 期刊论文
NATURE CHEMICAL BIOLOGY, 3111, 期号: 0, 页码: 1—5
Authors:  Pauline Macheboeuf;  Delphine S Fischer;  Tom Brown Jr;  Astrid Zervosen;  Andre´Luxen;  Bernard Joris;  Andrea Dessen;  Christopher J Schofield
Adobe PDF(425Kb)  |  Favorite  |  View/Download:171/1  |  Submit date:2017/07/21
The TRPC channel blocker SKF 96365 Inhibits Glioblastoma Cell Growth by Enhancing Reverse Mode of the Na+/Ca2+ Exchanger and Increasing Intracellular Ca2+ 期刊论文
出版物, 3111, 期号: 0, 页码: 1-45
Authors:  M Song;  D Chen;  S P Yu
Adobe PDF(1390Kb)  |  Favorite  |  View/Download:229/1  |  Submit date:2017/07/24
Skf 96365  Trpc Channel  Glioblastoma  Calcium  na+/ca2+ Exchanger  Cell Cycle  Cell Death  
Guaiane-type Sesquiterpenoid Dimers from Artemisia zhongdianensis and Antihepatoma Carcinoma Activity via the p38MAPK Pathway 期刊论文
CHINESE JOURNAL OF CHEMISTRY, 2023, 卷号: 41, 期号: 19, 页码: 2453-2468
Authors:  Dong,Wei;  Ma,Wen-Jing;  Ma,Yun-Bao;  Li,Feng-Jiao;  Li,Tian-Ze;  Wang,Yong-Cui;  He,Xiao-Feng;  Geng,Chang-An;  Zhang,Xue-Mei;  Chen,Ji-Jun
View  |  Adobe PDF(3816Kb)  |  Favorite  |  View/Download:62/18  |  Submit date:2024/07/10
Artemzhongdianolides B1-B17  Artemisia zhongdianensis  Guaiane-type sesquiterpenoid dimers  Antihepatoma activity  p38MAPK pathway  Cancer  NMR spectroscopy  X-ray diffraction  ARREST  CELLS  JNK  
Artemeriopolides A-D, two types of sesquiterpenoid dimers with rare carbon skeletons from Artemisia eriopoda and their antihepatoma cytotoxicity 期刊论文
ORGANIC CHEMISTRY FRONTIERS, 2023, 卷号: 10, 期号: 11, 页码: 2635-2641
Authors:  He,Xiao-Feng;  Li,Qi-Hao;  Li,Tian-Ze;  Ma,Yun-Bao;  Dong,Wei;  Yang,Ke-Xin;  Geng,Chang-An;  Zhang,Hao-Wei;  Wang,Yuan;  Chen,Ji-Jun
View  |  Adobe PDF(1676Kb)  |  Favorite  |  View/Download:89/21  |  Submit date:2024/07/22
Development of actein derivatives as potent anti-triple negative breast cancer agents 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2023, 卷号: 89, 页码: 129307
Authors:  Zhang,Honglin;  Chen,Yiyan;  Huang,Songwen;  Xiao,Wen-Wen;  Qiu,Ming-Hua;  Shao,Li-Dong;  Chen,Chuan-Huizi;  Li,Dashan
View  |  Adobe PDF(1187Kb)  |  Favorite  |  View/Download:50/11  |  Submit date:2024/07/22
Actein  Modification  Triple negative breast cancer  Structure-activity relationships  Mechanism  GROWTH-INHIBITORY ACTIVITY  BLACK COHOSH  EXTRACTS  
Cytotoxic C-20 non-oxygenated ent-kaurane diterpenoids from Isodon wardii 期刊论文
BIOORGANIC CHEMISTRY, 2023, 卷号: 135, 页码: 106512
Authors:  Tan,Qian;  Hu,Kun;  Li,Xiao-Nian;  Yang,Xing-Zhi;  Sun,Han-Dong;  Puno,Pema-Tenzin
View  |  Adobe PDF(3171Kb)  |  Favorite  |  View/Download:103/14  |  Submit date:2024/07/22
Isodon wardii  ent-Kauranoids  Cytotoxicity  Apoptosis  Cell cycle  
Cytotoxic and pro-apoptotic effects of botanical drugs derived from the indigenous cultivated medicinal plant Paris polyphylla var. yunnanensis 期刊论文
FRONTIERS IN PHARMACOLOGY, 2023, 卷号: 14, 页码: 1100825
Authors:  Yan,Xiu-Xiang;  Zhao,Yan-Qiang;  He,Yun;  Disayathanoowat,Terd;  Pandith,Hataichanok;  Inta,Angkhana;  Yang,Li-Xin
View  |  Adobe PDF(3195Kb)  |  Favorite  |  View/Download:108/10  |  Submit date:2024/05/09
Paris polyphylla var  yunnanensis  indigenous medicine knowledge  saponins  cytotoxic effects  pro-apoptotic effects  CELL-CYCLE ARREST  STEROIDAL SAPONINS  HEPATOCELLULAR-CARCINOMA  CHEMICAL-CONSTITUENTS  ASSAY  GLYCOSIDES  LEAVES  GROWTH  STEMS  SITES  
山地香茶菜的化学成分及其生物活性研究 学位论文
: 中国科学院大学, 2022
Authors:  邱彩玲
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山地香茶菜,二萜,细胞毒,促进溶酶体功能  Isodon oresbius, Diterpenoids, Cytotoxicity, Promotion of lysosomal function  
新型天然铁死亡诱导剂的筛选及作用机制研究 学位论文
: 中国科学院大学, 2022
Authors:  赵越勤
Adobe PDF(5494Kb)  |  Favorite  |  View/Download:69/0  |  Submit date:2024/05/14
肿瘤,天然产物,铁死亡,溶酶体,p53  Cancer, Nature products, Ferroptosis, Lysosome, p53