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The Protective Roles of PPAR alpha Activation in Triptolide-Induced Liver Injury 期刊论文
TOXICOLOGICAL SCIENCES, 2019, 卷号: 171, 期号: 1, 页码: 1-12
Authors:  Hu, Dan-Dan;  Zhao, Qi;  Cheng, Yan;  Xiao, Xue-Rong;  Huang, Jian-Feng;  Qu, Yan;  Li, Xian;  Tang, Ying-Mei;  Bao, Wei-Min;  Yang, Jin-Hui;  Jiang, Tao;  Hu, Jia-Peng;  Gonzalez, Frank J.;  Li, Fei
View  |  Adobe PDF(1740Kb)  |  Favorite  |  View/Download:8/0  |  Submit date:2020/03/26
liver injury  metabolomics  PPAR alpha  acylcarnitines  
The natural product antroalbol H promotes phosphorylation of liver kinase B1 (LKB1) at threonine 189 and thereby enhances cellular glucose uptake 期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2019, 卷号: 294, 期号: 27, 页码: 10415-10427
Authors:  Wang, Fang;  Yang, Xiaoyan;  Lu, Yanting;  Li, Zhenghui;  Xu, Yuhui;  Hu, Jing;  Liu, Jikai;  Xiong, Wenyong
View  |  Adobe PDF(4461Kb)  |  Favorite  |  View/Download:48/5  |  Submit date:2019/09/10
glucose metabolism  liver kinase B1 (LKB1)  AMP-activated kinase (AMPK)  glucose transporter type 4 (GLUT4)  fungi  Basidiomycete  diabetes  energy sensing  glucose homeostasis  sesquiterpene  
Hepatoprotective steroids from roots of Cynanchum otophyllum 期刊论文
FITOTERAPIA, 2019, 卷号: 136, 页码: 7
Authors:  Dong, Jinrun;  Peng, Xingrong;  Lu, Shuangyang;  Zhou, Lin;  Qiu, Minghua
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Cynanchum otophyllum  Asclepiadaceae  Steriods  Anti-liver fibrosis activity  
RA-XII Suppresses the Development and Growth of Liver Cancer by Inhibition of Lipogenesis via SCAP-dependent SREBP Supression 期刊论文
MOLECULES, 2019, 卷号: 24, 期号: 9, 页码: 14
Authors:  Guo, Di;  Wang, Yurong;  Wang, Jing;  Song, Lihua;  Wang, Zhe;  Mao, Bingyu;  Tan, Ninghua
View  |  Adobe PDF(9639Kb)  |  Favorite  |  View/Download:20/0  |  Submit date:2019/07/29
RA-XII  lipogenesis  SCAP  SREBP  liver cancer  
Lanostane-type triterpenoids from the fruiting bodies of Ganoderma applanatum 期刊论文
PHYTOCHEMISTRY, 2019, 卷号: 157, 页码: 103-110
Authors:  Peng, XingRong;  Li, Lei;  Dong, JinRun;  Lu, ShuangYang;  Lu, Jing;  Li, XiaoNian;  Zhou, Lin;  Qiu, MingHua
View  |  Adobe PDF(830Kb)  |  Favorite  |  View/Download:680/199  |  Submit date:2019/01/22
Ganoderma applanatum (Pers.) Pat.  Ganodermataceae  Lanostane-type triterpenoid  X-ray crystallographic analyses  Anti-liver fibrosis activity  
Metabolomic analysis of cholestatic liver damage in mice 期刊论文
FOOD AND CHEMICAL TOXICOLOGY, 2018, 卷号: 120, 页码: 253-260
Authors:  Yang, Rui;  Zhao, Qi;  Hu, Dan-Dan;  Xiao, Xue-Rong;  Huang, Jian-Feng;  Li, Fei
Favorite  |  View/Download:38/0  |  Submit date:2018/11/12
Cholestatic liver damage  PBC  PSC  Metabolomics  QTOFMS  
Natural Cyclopeptide RA-XII, a New Autophagy Inhibitor, Suppresses Protective Autophagy for Enhancing Apoptosis through AMPK/mTOR/P70S6K Pathways in HepG2 Cells 期刊论文
MOLECULES, 2017, 卷号: 22, 期号: 11, 页码: UNSP 1934
Authors:  Song, Lihua;  Wang, Zhe;  Wang, Yurong;  Guo, Di;  Yang, Jianhong;  Chen, Lijuan;  Tan, Ninghua
View  |  Adobe PDF(4110Kb)  |  Favorite  |  View/Download:55/5  |  Submit date:2018/05/08
Ra-xii  Cyclopeptide  Autophagy  Apoptosis  Mtor  Hepg2 Liver Cancer Cells  
Borapetoside E, a Clerodane Diterpenoid Extracted from Tinospora crispa, Improves Hyperglycemia and Hyperlipidemia in High-Fat-Diet-Induced Type 2 Diabetes Mice 期刊论文
JOURNAL OF NATURAL PRODUCTS, 2017, 卷号: 80, 期号: 8, 页码: 2319-2327
Authors:  Xu, Yuhui;  Niu, Yanfen;  Gao, Yuan;  Wang, Fang;  Qin, Wanying;  Lu, Yanting;  Hu, Jing;  Peng, Li;  Liu, Jikai;  Xiong, Wenyong
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Insulin-resistance  Tuberculata Beumee  Metabolic Syndrome  Srebp  Liver  Cholesterol  Constituents  Homeostasis  Inhibition  Receptors  
In vitro assessment of the glucose-lowering effects of berberrubine-9-O-beta-D-glucuronide, an active metabolite of berberrubine 期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 3, 页码: 351-361
Authors:  Yang, Na;  Sun, Run-Bin;  Chen, Xing-Long;  Zhen, Le;  Ge, Chun;  Zhao, Yu-Qing;  He, Jun;  Geng, Jian-Liang;  Guo, Jia-Hua;  Yu, Xiao-Yi;  Fei, Fei;  Feng, Si-Qi;  Zhu, Xuan-Xuan;  Wang, Hong-Bo;  Fu, Feng-Hua;  Aa, Ji-Ye;  Wang, Guang-Ji
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Hyperglycemia  Glucose-lowering Effect  Berberine  Berberrubine  Glucuronide  Alpha-glycosidase  Hfd-induced Hyperglycemia Model Of C57bl/6 Mice  Human Normal Liver Cell Line L-o2  Pharmacokinetics  
Metabolic profiling of myrislignan by UPLC-ESI-QTOFMS-based metabolomics 期刊论文
RSC ADVANCES, 2017, 卷号: 7, 期号: 64, 页码: 40131-40140
Authors:  Yang, Xiao-Nan;  Lv, Qian-Qian;  Zhao, Qi;  Li, Xin-Mei;  Yan, Dong-Mei;  Yang, Xiu-Wei;  Li, Fei
View  |  Adobe PDF(956Kb)  |  Favorite  |  View/Download:130/37  |  Submit date:2017/10/23
Myristica-fragrans  In-vitro  Liver-microsomes  Neolignans  Extract  Lignans  Pharmacokinetics  Identification  Noscapine  Reveals