Toxicity and Antiulcer Properties of Ipomoea wightii (Wall.) Choisy Leaves: An In Vivo Approach Using Wistar Albino Rats

doi:10.1155/2022/4328571

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	Toxicity and Antiulcer Properties of Ipomoea wightii (Wall.) Choisy Leaves: An In Vivo Approach Using Wistar Albino Rats
	Sathyanarayanan, Saikumar; Sreeja, Puthanpura Sasidharan; Arunachalam, Karuppusamy; Parimelazhagan, Thangaraj
	2022
发表期刊	EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
卷号	2022 页码:4328571
摘要	Humans have been using herbs to prevent and cure various ailments since antiquity, and Ipomoea wightii is a significant medicinal plant known for its wide ethnobotanical uses. Although the plant is known to treat ulcers, there is no significant scientific validation. The present study aimed to assess the acute toxicity, subacute toxicity, and antiulcer properties of the leaf methanol extract of I. wightii (IWL). In the subacute study, the extracts were given orally at 100, 200, and 400 mg/kg doses for 28 days, and we analyzed the biochemical and histological parameters to evaluate the toxicity of IWL. Two different models were assessed to explore antiulcer properties, such as indomethacin- and ethanol-induced ulcer model. Ulcer areas and ulceration percentage histopathology of the stomach were used to study the efficacy of extracts. The acute toxicity study showed that IWL was safe to the maximum dose of 2000 mg/kg body weight. In a subacute toxicity study, the oral administration of IWL did not produce any mortality in the tested animals. The analysis of haematological, liver biochemical, kidney profile, lipid profile, and in vivo antioxidant parameters depicted that all the values were within the control limits after the experimental period and were considered nontoxic to animals. Additionally, the antiulcer study demonstrated a positive response of IWL in a dose-related manner (indomethacin- and ethanol-induced models). Macroscopic analysis showed that pretreatment with I. wightii leaf methanol extract significantly reduced the gastric lesion and decreased the ulceration area (14.52 mm(2)), demonstrating superior results to the positive control group (27.71 mm(2)). The histopathological analysis revealed that pretreatment with a high dose of 400 mg/kg of I. wightii leaf methanol extract and positive control group (omeprazole) markedly protected pathological effects, and the gastric mucosa appeared normal. In conclusion, I. wightii has solid nontoxic potential as a promising native herb for an integral therapy for the treatment of ulcers.
关键词	GLUTATHIONE-REDUCTASE MEDICINAL-PLANTS METHANOL EXTRACT GASTRIC-ULCER GAERTN. ROXB. ANTIOXIDANT PALMITOYLETHANOLAMIDE METABOLISM LIVER
DOI	10.1155/2022/4328571
收录类别	SCI
WOS记录号	WOS:000806027100007
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/74658
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Sathyanarayanan, Saikumar,Sreeja, Puthanpura Sasidharan,Arunachalam, Karuppusamy,et al. Toxicity and Antiulcer Properties of Ipomoea wightii (Wall.) Choisy Leaves: An In Vivo Approach Using Wistar Albino Rats[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2022,2022:4328571.
APA	Sathyanarayanan, Saikumar,Sreeja, Puthanpura Sasidharan,Arunachalam, Karuppusamy,&Parimelazhagan, Thangaraj.(2022).Toxicity and Antiulcer Properties of Ipomoea wightii (Wall.) Choisy Leaves: An In Vivo Approach Using Wistar Albino Rats.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2022,4328571.
MLA	Sathyanarayanan, Saikumar,et al."Toxicity and Antiulcer Properties of Ipomoea wightii (Wall.) Choisy Leaves: An In Vivo Approach Using Wistar Albino Rats".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2022(2022):4328571.

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