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Anticarin-beta shows a promising anti-osteosarcoma effect by specifically inhibiting CCT4 to impair proteostasis 期刊论文
ACTA PHARMACEUTICA SINICA B, 2022, 卷号: 12, 期号: 5, 页码: 2268-2279
作者:  Wang, Gan;  Zhang, Min;  Meng, Ping;  Long, Chengbo;  Luo, Xiaodong;  Yang, Xingwei;  Wang, Yunfei;  Zhang, Zhiye;  Mwangi, James;  Kamau, Peter Muiruri;  Dai, Zhi;  Ke, Zunfu;  Zhang, Yi;  Chen, Wenlin;  Zhao, Xudong;  Ge, Fei;  Lv, Qiumin;  Rong, Mingqiang;  Li, Dongsheng;  Jin, Yang;  Sheng, Xia;  Lai, Ren
浏览  |  Adobe PDF(4759Kb)  |  收藏  |  浏览/下载：0/0  |  提交时间：2024/04/30
Proteostasis  CCT  TRiC  Osteosarcoma  STAT3  Anticarin-beta  PDX model  CYTOSOLIC CHAPERONIN  CANCER-CELLS  COMPLEX  EXPRESSION  SURVIVAL  PROTEIN  TUBULIN  GROWTH  
The safety and tolerability of alkaloids from Alstonia scholaris leaves in healthy Chinese volunteers: a single-centre, randomized, double-blind, placebo-controlled phase I clinical trial 期刊论文
PHARMACEUTICAL BIOLOGY, 2021, 卷号: 59, 期号: 1, 页码: 484-493
作者:  Gou,Zhong-Ping;  Zhao,Yun-Li;  Zou,Lin-Ling;  Wang,Ying;  Shu,Shi-Qing;  Zhu,Xiao-Hong;  Zheng,Li;  Shen,Qi;  Luo,Zhu;  Miao,Jia;  Wang,Yong-Sheng;  Luo,Xiao-Dong;  Feng,Ping
收藏  |  浏览/下载：56/0  |  提交时间：2022/04/02
Clinical safety  healthy subject  dose-escalation study  MONOTERPENOID INDOLE ALKALOIDS  FLIGHT MASS-SPECTROMETRY  EXTRACT  IDENTIFICATION  CONSTITUENTS  
Anti-microbial Effects In Vitro and In Vivo of Alstonia scholaris 期刊论文
Natural products and bioprospecting, 2021, 卷号: 11, 期号: 1, 页码: 127-135
作者:  Zhao,Yun-Li;  Gou,Zhong-Ping;  Shang,Jian-Hua;  Li,Wan-Yi;  Kuang,Yu;  Li,Ming-Yuan;  Luo,Xiao-Dong
浏览  |  Adobe PDF(958Kb)  |  收藏  |  浏览/下载：95/30  |  提交时间：2022/04/02
Antioxidant and Cytoprotective Effects of New Diarylheptanoids from Rhynchanthus beesianus 期刊论文
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2021, 卷号: 69, 期号: 22, 页码: 6229-6239
作者:  Zhu,Pei-Feng;  Cheng,Gui-Guang;  Zhao,Lan-Qin;  Khan,Afsar;  Yang,Xing-Wei;  Zhang,Bu-Yun;  Li,Meng-Cheng;  Liu,Ya-Ping;  Luo,Xiao-Dong
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Rhynchanthus beesianus  diarylheptanoid  antioxidant activity  intracellular reactive oxygen species  cell apoptosis  GINGER ZINGIBER-OFFICINALE  PC12 CELLS  RHIZOMES  NEUROPROTECTION  ACTIVATION  ENZYMES  L.  
Diverse isoquinolines with anti-inflammatory and analgesic bioactivities from Hypecoum erectum 期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2021, 卷号: 270, 页码: 113811
作者:  Yuan,Hai-Lian;  Zhao,Yun-Li;  Qin,Xu-Jie;  Liu,Ya-Ping;  Yang,Xing-Wei;  Luo,Xiao-Dong
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Hypecoum erectum  Isoquinoline alkaloids  Anti-inflammatory activity  Analgesic activity  Inflammatory mediators  
Structures/cytotoxicity/selectivity relationship of natural steroidal saponins against GSCs and primary mechanism of tribulosaponin A 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 210, 页码: 113068
作者:  Dai,Zhi;  Liu,Hui;  Wang,Bei;  Yang,Dong;  Zhu,Yan-Yan;  Yan,Huan;  Zhu,Pei-Feng;  Liu,Ya-Ping;  Chen,Hui-Cheng;  Zhao,Yun-li;  Zhao,Li-Xing;  Zhao,Xu-Dong;  Liu,Hai-Yang;  Luo,Xiao-Dong
浏览  |  Adobe PDF(2630Kb)  |  收藏  |  浏览/下载：143/81  |  提交时间：2022/04/02
Steroidal saponins  Structure-activity relationship  Tribulosaponin A  Glioma stem cells  ROS  SMALL MOLECULES  CARDIAC-ARREST  STEM-CELL  IDENTIFICATION  THERAPY  BRAIN  OPPORTUNITIES  GLIOMA  TUMORS  NOX2  
Pharmacological effects of indole alkaloids from Alstonia scholaris (L.) R. Br. on pulmonary fibrosis in vivo 期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2021, 卷号: 267, 页码: 113506
作者:  Zhao,Yun-Li;  Pu,Shi-Biao;  Qi,Yan;  Wu,Bai-Fen;  Shang,Jian-Hua;  Liu,Ya-Ping;  Hu,Di;  Luo,Xiao-Dong
浏览  |  Adobe PDF(9993Kb)  |  收藏  |  浏览/下载：68/28  |  提交时间：2022/04/02
Alstonia scholaris  Indole alkaloids  Pulmonary fibrosis  Picrinine  Vallesamine  Scholaricine  19-Epischolaricine  FLIGHT MASS-SPECTROMETRY  ACUTE LUNG INJURY  AIRWAY INFLAMMATION  OXIDATIVE STRESS  BARK EXTRACTS  LEAVES  CONSTITUENTS  COLLAGEN  LEAF  KL-6  
Phytochemicals and Allelopathy of Induced Water Hyacinth against Microcystis aeruginosa 期刊论文
JOURNAL OF NATURAL PRODUCTS, 2021, 卷号: 84, 期号: 6, 页码: 1772-1779
作者:  Cheng,Gui-Guang;  Liu,Ya-Ping;  Gu,Ji;  Qian,Sheng-Yan;  Yang,Hong-Jun;  Na,Zhong-Yuan;  Luo,Xiao-Dong
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PHYTOALEXINS  METABOLITES  PLANTS  
Rapid and unambiguous assignment of proton-deficient N-acyl amidine indole alkaloid by a combination of calculation methods 期刊论文
TETRAHEDRON LETTERS, 2021, 卷号: 68, 页码: 152949
作者:  Ding,Cai-Feng;  Yu,Hao-Fei;  Shi,Xiao-Long;  Ge,Shi-Cheng;  Njateng,Guy S. S.;  Qin,Xu-Jie;  Dai,Zhi;  Zhang,Rong-Ping;  Zhang,Hong-Bin;  Luo,Xiao-Dong
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N-acyl amidine  Voafriamidine  Calculation methods  Antimicrobial activity  ASSISTED STRUCTURE ELUCIDATION  APORPHINE  DERIVATIVES  C-13  TOOL  
Alstoscholarisine K, an Antimicrobial Indole from Gall-Induced Leaves of Alstonia scholaris 期刊论文
ORGANIC LETTERS, 2021, 卷号: 23, 期号: 15, 页码: 5782-5786
作者:  Yu,Hao-Fei;  Ding,Cai-Feng;  Zhang,Lan-Chun;  Wei,Xin;  Cheng,Gui-Guang;  Liu,Ya-Ping;  Zhang,Rong-Ping;  Luo,Xiao-Dong
浏览  |  Adobe PDF(1658Kb)  |  收藏  |  浏览/下载：58/18  |  提交时间：2022/04/02
ALKALOIDS  MECHANISM