Pharmacological effects of indole alkaloids from Alstonia scholaris (L.) R. Br. on pulmonary fibrosis in vivo
Zhao,Yun-Li; Pu,Shi-Biao; Qi,Yan; Wu,Bai-Fen; Shang,Jian-Hua; Liu,Ya-Ping; Hu,Di; Luo,Xiao-Dong
AbstractEthnopharmacological relevance: Alstonia scholaris (L.) R. Br. (Apocynaceae) is a Dai folk medicine for the treatment of lung diseases in China.Aim of the study: The present study investigated the anti-pulmonary fibrosis effects of total alkaloids (TA) and the potential active ingredients and its possible mechanism.Materials and methods: After intratracheal instillation of bleomycin (BLM, 5 mg/kg), mice were divided into ten groups, and orally treated with the corresponding samples once daily for 28 days. The effect of indole alkaloids was determined through analysis of cytokines, as well as histopathological examinations and gene expressions.Results: Severe lung fibrosis was observed in the BLM-treated mice on day 28. However, the administration of TA significantly ameliorated the pathological changes in the lungs, decreased the content of Krebs von den Lungen-6, lactate dehydrogenase, transforming growth factor-beta (TGF-beta), hydroxyproline, type I collagen, and malonaldehyde, and enhanced the activity of superoxide dismutase in the serum and lung tissues. In addition, the enhanced TGF-beta and matrix metalloproteinase-1 (MMP-1) expressions in BLM-induced mice were obviously weakened by indole alkaloids, as well as the ratio of matrix metalloproteinase-1 to tissue inhibitor of metalloproteinase-1 was decreased. Moreover, picrinine and scholaricine yielded markedly better values in the aforementioned indices than those in other samples, indicating that they may be the active ingredients of alkaloids.Conclusions: TA exerted protective effects against BLM-induced pulmonary fibrosis by reducing collagen deposition through TGF-beta/MMP-1 pathway.
KeywordAlstonia scholaris Indole alkaloids Pulmonary fibrosis Picrinine Vallesamine Scholaricine 19-Epischolaricine FLIGHT MASS-SPECTROMETRY ACUTE LUNG INJURY AIRWAY INFLAMMATION OXIDATIVE STRESS BARK EXTRACTS LEAVES CONSTITUENTS COLLAGEN LEAF KL-6
WOS IDWOS:000606365200004
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Affiliation1.Yunnan Univ, Key Lab Med Chem Nat Resource, Minist Educ & Yunnan Prov, Sch Chem Sci & Technol, Kunming 650091, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
3.Yunnan Univ Chinese Med, Chinese Mat Med, Kunming 650500, Yunnan, Peoples R China
4.Yunnan Prov Hosp TCM, Kunming 650021, Yunnan, Peoples R China
5.Yunnan Univ Business Management, Kunming 650500, Yunnan, Peoples R China
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Zhao,Yun-Li,Pu,Shi-Biao,Qi,Yan,et al. Pharmacological effects of indole alkaloids from Alstonia scholaris (L.) R. Br. on pulmonary fibrosis in vivo[J]. JOURNAL OF ETHNOPHARMACOLOGY,2021,267:113506.
APA Zhao,Yun-Li.,Pu,Shi-Biao.,Qi,Yan.,Wu,Bai-Fen.,Shang,Jian-Hua.,...&Luo,Xiao-Dong.(2021).Pharmacological effects of indole alkaloids from Alstonia scholaris (L.) R. Br. on pulmonary fibrosis in vivo.JOURNAL OF ETHNOPHARMACOLOGY,267,113506.
MLA Zhao,Yun-Li,et al."Pharmacological effects of indole alkaloids from Alstonia scholaris (L.) R. Br. on pulmonary fibrosis in vivo".JOURNAL OF ETHNOPHARMACOLOGY 267(2021):113506.
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