Antioxidant and Cytoprotective Effects of New Diarylheptanoids from Rhynchanthus beesianus
Zhu,Pei-Feng; Cheng,Gui-Guang; Zhao,Lan-Qin; Khan,Afsar; Yang,Xing-Wei; Zhang,Bu-Yun; Li,Meng-Cheng; Liu,Ya-Ping; Luo,Xiao-Dong
AbstractRhynchanthus beesianus (Zingiberaceae) has been an important food spice and vegetable in southern China. Fifteen phenolic compounds (1-15) including three new diarylheptanoids, rhynchanines A-C (1-3) and one new phenylpropanoid, 4-O-methylstroside B (9), were isolated from R. beesianus rhizomes. The structures of new compounds were elucidated by comprehensive analyses through NMR, HRMS technique, acid hydrolysis, and Mosher's reaction. Among them, compound 5 is the first isolated natural product and its NMR data are reported. Most of the isolated compounds, especially 3-6 and 8, showed significant antioxidant activities on DPPH, ABTS(+) radical scavenging, and FRAP assays. Furthermore, the antioxidant phenolic compounds were evaluated for their cytoprotective capacity against H2O2 -induced oxidative stress in HepG-2 cells. Compounds 3 and 5 could significantly inhibit reactive oxygen species production, and compounds 3, 5, and 6 could remarkably prevent the cell apoptosis. Then, the R. beesianus rhizome, which contained phenolic compounds, might serve as a functional food for potential application on preventing oxidative stress-connected diseases.
KeywordRhynchanthus beesianus diarylheptanoid antioxidant activity intracellular reactive oxygen species cell apoptosis GINGER ZINGIBER-OFFICINALE PC12 CELLS RHIZOMES NEUROPROTECTION ACTIVATION ENZYMES L.
WOS IDWOS:000662082500011
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Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Kunming Univ Sci & Technol, Fac Agr & Food, Kunming 650500, Yunnan, Peoples R China
4.COMSATS Univ Islamabad, Dept Chem, Abbottabad 22060, Pakistan
5.Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource, Minist Educ & Yunnan Prov, Kunming 650091, Yunnan, Peoples R China
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Zhu,Pei-Feng,Cheng,Gui-Guang,Zhao,Lan-Qin,et al. Antioxidant and Cytoprotective Effects of New Diarylheptanoids from Rhynchanthus beesianus[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2021,69(22):6229-6239.
APA Zhu,Pei-Feng.,Cheng,Gui-Guang.,Zhao,Lan-Qin.,Khan,Afsar.,Yang,Xing-Wei.,...&Luo,Xiao-Dong.(2021).Antioxidant and Cytoprotective Effects of New Diarylheptanoids from Rhynchanthus beesianus.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,69(22),6229-6239.
MLA Zhu,Pei-Feng,et al."Antioxidant and Cytoprotective Effects of New Diarylheptanoids from Rhynchanthus beesianus".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 69.22(2021):6229-6239.
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