Antioxidant and Cytoprotective Effects of New Diarylheptanoids from Rhynchanthus beesianus

doi:10.1021/acs.jafc.1c00869

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	Antioxidant and Cytoprotective Effects of New Diarylheptanoids from Rhynchanthus beesianus
	Zhu,Pei-Feng ; Cheng,Gui-Guang ; Zhao,Lan-Qin ; Khan,Afsar ; Yang,Xing-Wei; Zhang,Bu-Yun ; Li,Meng-Cheng ; Liu,Ya-Ping ; Luo,Xiao-Dong
	2021
发表期刊	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
ISSN	0021-8561
卷号	69 期号:22 页码:6229-6239
摘要	Rhynchanthus beesianus (Zingiberaceae) has been an important food spice and vegetable in southern China. Fifteen phenolic compounds (1-15) including three new diarylheptanoids, rhynchanines A-C (1-3) and one new phenylpropanoid, 4-O-methylstroside B (9), were isolated from R. beesianus rhizomes. The structures of new compounds were elucidated by comprehensive analyses through NMR, HRMS technique, acid hydrolysis, and Mosher's reaction. Among them, compound 5 is the first isolated natural product and its NMR data are reported. Most of the isolated compounds, especially 3-6 and 8, showed significant antioxidant activities on DPPH, ABTS(+) radical scavenging, and FRAP assays. Furthermore, the antioxidant phenolic compounds were evaluated for their cytoprotective capacity against H2O2 -induced oxidative stress in HepG-2 cells. Compounds 3 and 5 could significantly inhibit reactive oxygen species production, and compounds 3, 5, and 6 could remarkably prevent the cell apoptosis. Then, the R. beesianus rhizome, which contained phenolic compounds, might serve as a functional food for potential application on preventing oxidative stress-connected diseases.
关键词	Rhynchanthus beesianus diarylheptanoid antioxidant activity intracellular reactive oxygen species cell apoptosis GINGER ZINGIBER-OFFICINALE PC12 CELLS RHIZOMES NEUROPROTECTION ACTIVATION ENZYMES L.
DOI	10.1021/acs.jafc.1c00869
WOS记录号	WOS:000662082500011
引用统计	被引频次：14[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73447
专题	中国科学院昆明植物研究所
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Kunming Univ Sci & Technol, Fac Agr & Food, Kunming 650500, Yunnan, Peoples R China 4.COMSATS Univ Islamabad, Dept Chem, Abbottabad 22060, Pakistan 5.Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource, Minist Educ & Yunnan Prov, Kunming 650091, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Zhu,Pei-Feng,Cheng,Gui-Guang,Zhao,Lan-Qin,et al. Antioxidant and Cytoprotective Effects of New Diarylheptanoids from Rhynchanthus beesianus[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2021,69(22):6229-6239.
APA	Zhu,Pei-Feng.,Cheng,Gui-Guang.,Zhao,Lan-Qin.,Khan,Afsar.,Yang,Xing-Wei.,...&Luo,Xiao-Dong.(2021).Antioxidant and Cytoprotective Effects of New Diarylheptanoids from Rhynchanthus beesianus.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,69(22),6229-6239.
MLA	Zhu,Pei-Feng,et al."Antioxidant and Cytoprotective Effects of New Diarylheptanoids from Rhynchanthus beesianus".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 69.22(2021):6229-6239.

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