Alstoscholarisine K, an Antimicrobial Indole from Gall-Induced Leaves of Alstonia scholaris

doi:10.1021/acs.orglett.1c01942

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	Alstoscholarisine K, an Antimicrobial Indole from Gall-Induced Leaves of Alstonia scholaris
	Yu,Hao-Fei ; Ding,Cai-Feng ; Zhang,Lan-Chun ; Wei,Xin ; Cheng,Gui-Guang ; Liu,Ya-Ping ; Zhang,Rong-Ping ; Luo,Xiao-Dong
	2021
发表期刊	ORGANIC LETTERS
ISSN	1523-7060
卷号	23 期号:15 页码:5782-5786
摘要	Alstoscholarisine K, an indole alkaloid with eight chiral carbons and featuring a novel 6/5/6/6/6/6/6/5 octacyclic architecture, was found to be specific to the gall-infected leaves of Alstonia scholaris. Its structure was elucidated by spectroscopy, computational analysis, and single-crystal X-ray diffraction. The unusual highly fused cage-like pyrrolo[1,2-a]pyrimidine structure with an additional -C4N unit is possibly derived from a combination of monoterpenoid indole and polyamine pathways. The fascinating compound exhibited significant antibacterial bioactivities by targeting cell membranes.
关键词	ALKALOIDS MECHANISM
DOI	10.1021/acs.orglett.1c01942
WOS记录号	WOS:000684033200114
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73429
专题	中国科学院昆明植物研究所
作者单位	1.[Yu, Hao-Fei 2.Ding, Cai-Feng 3.Wei, Xin 4.Liu, Ya-Ping 5.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 6.Yunnan Univ, Minist Educ, Key Lab Med Chem Nat Resources, Kunming 650091, Yunnan, Peoples R China 7.Yunnan Univ, Sch Chem Sci & Technol, Yunnan Prov Ctr Res & Dev Nat Prod, Kunming 650091, Yunnan, Peoples R China 8.Zhang, Lan-Chun 9.Kunming Med Univ, Sch Pharmaceut Sci, Dept Zool, Kunming 650500, Yunnan, Peoples R China 10.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Yunnan, Peoples R China 11.[Cheng, Gui-Guang 12.Kunming Univ Sci & Technol, Yunnan Inst Food Safety, Kunming 650500, Yunnan, Peoples R China 13.Yunnan Univ Tradit Chinese Med, Sch Chinese Mat Med, Kunming 650500, Yunnan, Peoples R China 14.Yunnan Univ Tradit Chinese Med, Yunnan Key Lab Southern Med Resources, Kunming 650500, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Yu,Hao-Fei,Ding,Cai-Feng,Zhang,Lan-Chun,et al. Alstoscholarisine K, an Antimicrobial Indole from Gall-Induced Leaves of Alstonia scholaris[J]. ORGANIC LETTERS,2021,23(15):5782-5786.
APA	Yu,Hao-Fei.,Ding,Cai-Feng.,Zhang,Lan-Chun.,Wei,Xin.,Cheng,Gui-Guang.,...&Luo,Xiao-Dong.(2021).Alstoscholarisine K, an Antimicrobial Indole from Gall-Induced Leaves of Alstonia scholaris.ORGANIC LETTERS,23(15),5782-5786.
MLA	Yu,Hao-Fei,et al."Alstoscholarisine K, an Antimicrobial Indole from Gall-Induced Leaves of Alstonia scholaris".ORGANIC LETTERS 23.15(2021):5782-5786.

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