Knowledge Management System of Kunming Institute of Botany,CAS
| Alstoscholarisine K, an Antimicrobial Indole from Gall-Induced Leaves of Alstonia scholaris | |
Yu,Hao-Fei; Ding,Cai-Feng; Zhang,Lan-Chun; Wei,Xin; Cheng,Gui-Guang; Liu,Ya-Ping; Zhang,Rong-Ping; Luo,Xiao-Dong
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| 2021 | |
| Source Publication | ORGANIC LETTERS
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| ISSN | 1523-7060 |
| Volume | 23Issue:15Pages:5782-5786 |
| Abstract | Alstoscholarisine K, an indole alkaloid with eight chiral carbons and featuring a novel 6/5/6/6/6/6/6/5 octacyclic architecture, was found to be specific to the gall-infected leaves of Alstonia scholaris. Its structure was elucidated by spectroscopy, computational analysis, and single-crystal X-ray diffraction. The unusual highly fused cage-like pyrrolo[1,2-a]pyrimidine structure with an additional -C4N unit is possibly derived from a combination of monoterpenoid indole and polyamine pathways. The fascinating compound exhibited significant antibacterial bioactivities by targeting cell membranes. |
| Keyword | ALKALOIDS MECHANISM |
| DOI | 10.1021/acs.orglett.1c01942 |
| WOS ID | WOS:000684033200114 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/73429 |
| Collection | 中国科学院昆明植物研究所 |
| Affiliation | 1.[Yu, Hao-Fei 2.Ding, Cai-Feng 3.Wei, Xin 4.Liu, Ya-Ping 5.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 6.Yunnan Univ, Minist Educ, Key Lab Med Chem Nat Resources, Kunming 650091, Yunnan, Peoples R China 7.Yunnan Univ, Sch Chem Sci & Technol, Yunnan Prov Ctr Res & Dev Nat Prod, Kunming 650091, Yunnan, Peoples R China 8.Zhang, Lan-Chun 9.Kunming Med Univ, Sch Pharmaceut Sci, Dept Zool, Kunming 650500, Yunnan, Peoples R China 10.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Yunnan, Peoples R China 11.[Cheng, Gui-Guang 12.Kunming Univ Sci & Technol, Yunnan Inst Food Safety, Kunming 650500, Yunnan, Peoples R China 13.Yunnan Univ Tradit Chinese Med, Sch Chinese Mat Med, Kunming 650500, Yunnan, Peoples R China 14.Yunnan Univ Tradit Chinese Med, Yunnan Key Lab Southern Med Resources, Kunming 650500, Yunnan, Peoples R China |
| Recommended Citation GB/T 7714 | Yu,Hao-Fei,Ding,Cai-Feng,Zhang,Lan-Chun,et al. Alstoscholarisine K, an Antimicrobial Indole from Gall-Induced Leaves of Alstonia scholaris[J]. ORGANIC LETTERS,2021,23(15):5782-5786. |
| APA | Yu,Hao-Fei.,Ding,Cai-Feng.,Zhang,Lan-Chun.,Wei,Xin.,Cheng,Gui-Guang.,...&Luo,Xiao-Dong.(2021).Alstoscholarisine K, an Antimicrobial Indole from Gall-Induced Leaves of Alstonia scholaris.ORGANIC LETTERS,23(15),5782-5786. |
| MLA | Yu,Hao-Fei,et al."Alstoscholarisine K, an Antimicrobial Indole from Gall-Induced Leaves of Alstonia scholaris".ORGANIC LETTERS 23.15(2021):5782-5786. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| 053-E01-121-于-OL.pdf（1658KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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