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Metabolomics reveals the role of PPAR alpha in Tripterygium Wilfordii-induced liver injury 期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2022, 卷号: 289, 页码: 16
作者:  Dai, Manyun;  Peng, Wan;  Zhang, Ting;  Zhao, Qi;  Ma, Xiaofang;  Cheng, Yan;  Wang, Chunyan;  Li, Fei
收藏  |  浏览/下载：229/0  |  提交时间：2022/07/15
Tripterygium wilfordii  Liver injury  PPAR alpha  IL6-STAT3  Metabolomics  
Alisol B Alleviates Hepatocyte Lipid Accumulation and Lipotoxicity via Regulating RAR alpha-PPAR gamma-CD36 Cascade and Attenuates Non-Alcoholic Steatohepatitis in Mice 期刊论文
NUTRIENTS, 2022, 卷号: 14, 期号: 12, 页码: 2411
作者:  Zhao, Zhuohui;  Deng, Zhen-Tao;  Huang, Suling;  Ning, Mengmeng;  Feng, Ying;  Shen, Yu;  Zhao, Qin-Shi;  Leng, Ying
浏览  |  Adobe PDF(6451Kb)  |  收藏  |  浏览/下载：2/1  |  提交时间：2024/04/30
Alisol B  non-alcoholic steatohepatitis  RAR alpha  CD36  FATTY LIVER  HEPATIC STEATOSIS  RECEPTOR  ORIENTALE  LIPOPROTEINS  23-ACETATE  AGONIST  CD36  
Toxicity and Antiulcer Properties of Ipomoea wightii (Wall.) Choisy Leaves: An In Vivo Approach Using Wistar Albino Rats 期刊论文
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2022, 卷号: 2022, 页码: 4328571
作者:  Sathyanarayanan, Saikumar;  Sreeja, Puthanpura Sasidharan;  Arunachalam, Karuppusamy;  Parimelazhagan, Thangaraj
浏览  |  Adobe PDF(3038Kb)  |  收藏  |  浏览/下载：1/0  |  提交时间：2024/04/30
GLUTATHIONE-REDUCTASE  MEDICINAL-PLANTS  METHANOL EXTRACT  GASTRIC-ULCER  GAERTN. ROXB.  ANTIOXIDANT  PALMITOYLETHANOLAMIDE  METABOLISM  LIVER  
Lipid Disorders in NAFLD and Chronic Kidney Disease 期刊论文
BIOMEDICINES, 2021, 卷号: 9, 期号: 10, 页码: 1405
作者:  Yang,Meng;  Geng,Chang-An;  Liu,Xinguang;  Guan,Min
收藏  |  浏览/下载：47/0  |  提交时间：2022/04/02
lipid  NAFLD  chronic kidney disease  NONALCOHOLIC FATTY LIVER  ENDOPLASMIC-RETICULUM STRESS  MESENCHYMAL STEM-CELLS  INSULIN-RESISTANCE  LIPOPROTEIN METABOLISM  OBETICHOLIC ACID  RENAL-FIBROSIS  RECEPTOR-ALPHA  MOUSE MODEL  ER STRESS  
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 11, 页码: 7404-7421
作者:  Zhou,Zongyuan;  Li,Yiming;  Ma,Xiaofang;  Cao,Biyun;  Peng,Ting;  Sheng,Yuwen;  Peng,Huipan;  Li,Runze;  Cao,Yu;  Xi,Ruiying;  Li,Fu;  Wang,Mengru;  Sun,Handong;  Zhang,Guolin;  Zhang,Hongbin;  Hu,Kaifeng;  Xiao,Weilie;  Wang,Fei
收藏  |  浏览/下载：76/0  |  提交时间：2022/04/02
GOMISIN-A  DIBENZOCYCLOOCTADIENE LIGNANS  SCHISANDRA-CHINENSIS  MASS-SPECTROMETRY  MIRNA EXPRESSION  DOWN-REGULATION  NONCODING RNA  MICRORNA  LIVER  DICER  
Artemicapillasins A-N, cytotoxic coumaric acid analogues against hepatic stellate cell LX2 from Artemisia capillaris (Yin-Chen) 期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 117, 页码: 105441
作者:  Gao,Zhen;  Huang,Xiao-Yan;  Geng,Chang-An;  Li,Tian-Ze;  Chen,Ji-Jun
浏览  |  Adobe PDF(1872Kb)  |  收藏  |  浏览/下载：101/31  |  提交时间：2022/04/02
Artemisia capillaris  Coumaric acid analogues  Antihepatic fibrosis effects  HSC-LX2  Extracellular matrix  TRADITIONAL CHINESE HERB  ACTIVE CONSTITUENTS  LIVER FIBROSIS  
FXR activation prevents liver injury induced by Tripterygium wilfordii preparations 期刊论文
XENOBIOTICA, 2021, 卷号: 51, 期号: 6, 页码: 716-727
作者:  Peng,Wan;  Dai,Man-Yun;  Bao,Li-Juan;  Zhu,Wei-Feng;  Li,Fei
Adobe PDF(2010Kb)  |  收藏  |  浏览/下载：81/13  |  提交时间：2022/04/02
Tripterygium wilfordii  liver injury  farnesoid X receptor  bile acid metabolism  metabolomics  
Synthesis and anti-fibrotic effects of santamarin derivatives as cytotoxic agents against hepatic stellate cell line LX2 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2021, 卷号: 41, 页码: 127994
作者:  Wang,Jin-Ping;  Li,Tian-Ze;  Huang,Xiao-Yan;  Geng,Chang-An;  Shen,Cheng;  Sun,Jin-Jin;  Xue,Dong;  Chen,Ji-Jun
Adobe PDF(567Kb)  |  收藏  |  浏览/下载：68/23  |  提交时间：2022/04/02
Santamarin derivatives  Anti-fibrotic effects  HSC-LX2  Extracellular matrix  NF-KAPPA-B  SESQUITERPENE LACTONES  LIVER FIBROSIS  STRUCTURE REQUIREMENT  BAY LEAF  ACTIVATION  
The Protective Roles of PPAR alpha Activation in Triptolide-Induced Liver Injury 期刊论文
TOXICOLOGICAL SCIENCES, 2019, 卷号: 171, 期号: 1, 页码: 1-12
作者:  Hu, Dan-Dan;  Zhao, Qi;  Cheng, Yan;  Xiao, Xue-Rong;  Huang, Jian-Feng;  Qu, Yan;  Li, Xian;  Tang, Ying-Mei;  Bao, Wei-Min;  Yang, Jin-Hui;  Jiang, Tao;  Hu, Jia-Peng;  Gonzalez, Frank J.;  Li, Fei
Adobe PDF(1740Kb)  |  收藏  |  浏览/下载：180/21  |  提交时间：2020/03/26
liver injury  metabolomics  PPAR alpha  acylcarnitines  
The natural product antroalbol H promotes phosphorylation of liver kinase B1 (LKB1) at threonine 189 and thereby enhances cellular glucose uptake 期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2019, 卷号: 294, 期号: 27, 页码: 10415-10427
作者:  Wang, Fang;  Yang, Xiaoyan;  Lu, Yanting;  Li, Zhenghui;  Xu, Yuhui;  Hu, Jing;  Liu, Jikai;  Xiong, Wenyong
Adobe PDF(4461Kb)  |  收藏  |  浏览/下载：220/67  |  提交时间：2019/09/10
glucose metabolism  liver kinase B1 (LKB1)  AMP-activated kinase (AMPK)  glucose transporter type 4 (GLUT4)  fungi  Basidiomycete  diabetes  energy sensing  glucose homeostasis  sesquiterpene