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Lipid Disorders in NAFLD and Chronic Kidney Disease
Yang,Meng; Geng,Chang-An; Liu,Xinguang; Guan,Min
2021
Source PublicationBIOMEDICINES
ISSN2227-9059
Volume9Issue:10Pages:1405
AbstractNonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver dysfunction and is characterized by exaggerated lipid accumulation, inflammation and even fibrosis. It has been shown that NAFLD increases the risk of other chronic diseases, particularly chronic kidney disease (CKD). Lipid in excess could lead to liver and kidney lesions and even end-stage disease through diverse pathways. Dysregulation of lipid uptake, oxidation or de novo lipogenesis contributes to the toxic effects of ectopic lipids which promotes the development and progression of NAFLD and CKD via triggering oxidative stress, apoptosis, pro-inflammatory and profibrotic responses. Importantly, dyslipidemia and release of pro-inflammatory cytokines caused by NAFLD (specifically, nonalcoholic steatohepatitis) are considered to play important roles in the pathological progression of CKD. Growing evidence of similarities between the pathogenic mechanisms of NAFLD and those of CKD has attracted attention and urged researchers to discover their common therapeutic targets. Here, we summarize the current understanding of molecular aberrations underlying the lipid metabolism of NAFLD and CKD and clinical evidence that suggests the relevance of these pathways in humans. This review also highlights the orchestrated inter-organ cross-talk in lipid disorders, as well as therapeutic options and opportunities to counteract NAFLD and CKD.

Keywordlipid NAFLD chronic kidney disease NONALCOHOLIC FATTY LIVER ENDOPLASMIC-RETICULUM STRESS MESENCHYMAL STEM-CELLS INSULIN-RESISTANCE LIPOPROTEIN METABOLISM OBETICHOLIC ACID RENAL-FIBROSIS RECEPTOR-ALPHA MOUSE MODEL ER STRESS
DOI10.3390/biomedicines9101405
WOS IDWOS:000713002700001
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Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/73452
Collection中国科学院昆明植物研究所
Affiliation1.Guangdong Med Univ, Guangdong Prov Key Lab Med Mol Diagnost, Inst Biochem & Mol Biol, Inst Aging Res, Dongguan 523808, Peoples R China
2.Chinese Acad Sci, Ctr Human Tissues & Organs Degenerat, Inst Biomed & Biotechnol, Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China
3.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Yang,Meng,Geng,Chang-An,Liu,Xinguang,et al. Lipid Disorders in NAFLD and Chronic Kidney Disease[J]. BIOMEDICINES,2021,9(10):1405.
APA Yang,Meng,Geng,Chang-An,Liu,Xinguang,&Guan,Min.(2021).Lipid Disorders in NAFLD and Chronic Kidney Disease.BIOMEDICINES,9(10),1405.
MLA Yang,Meng,et al."Lipid Disorders in NAFLD and Chronic Kidney Disease".BIOMEDICINES 9.10(2021):1405.
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