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Metabolomics reveals the role of PPAR alpha in Tripterygium Wilfordii-induced liver injury 期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2022, 卷号: 289, 页码: 16
作者:  Dai, Manyun;  Peng, Wan;  Zhang, Ting;  Zhao, Qi;  Ma, Xiaofang;  Cheng, Yan;  Wang, Chunyan;  Li, Fei
收藏  |  浏览/下载：303/0  |  提交时间：2022/07/15
Tripterygium wilfordii  Liver injury  PPAR alpha  IL6-STAT3  Metabolomics  
Moringa oleifera seed ethanol extract and its active component kaempferol potentiate pentobarbital-induced sleeping behaviours in mice via a GABAergic mechanism 期刊论文
PHARMACEUTICAL BIOLOGY, 2022, 卷号: 60, 期号: 1, 页码: 810-824
作者:  Liu, Wei-Liang;  Wu, Bai-Fen;  Shang, Jian-Hua;  Wang, Xue-Feng;  Zhao, Yun-Li;  Huang, Ai-Xiang
浏览  |  Adobe PDF(4141Kb)  |  收藏  |  浏览/下载：32/6  |  提交时间：2024/04/30
Sedative-hypnotic  Cl- influx  GABA(A) receptors  GABA(A)-ergic systems  BLOOD-BRAIN-BARRIER  GABA(A) RECEPTORS  INSOMNIA  MODULATION  PHYSIOLOGY  FLAVONOIDS  TOXICITY  ANXIETY  NEURONS  DISEASE  
Hepatic RACK1 deletion disturbs lipid and glucose homeostasis independently of insulin resistance 期刊论文
JOURNAL OF ENDOCRINOLOGY, 2022, 卷号: 254, 期号: 3, 页码: 151-165
作者:  Qin, Wanying;  Zhang, Ting;  Ge, Mingxia;  Zhou, Huimin;  Xu, Yuhui;  Mu, Rongfang;  Huang, Chaoguang;  Liu, Daowei;  Huang, Bangrui;  Wang, Qian;  Kong, Qinghua;  Kong, Qingpeng;  Li, Fei;  Xiong, Wenyong
浏览  |  Adobe PDF(9525Kb)  |  收藏  |  浏览/下载：36/10  |  提交时间：2024/04/30
RACK1  bile acid  glucose metabolism  insulin sensitivity  ENDOPLASMIC-RETICULUM STRESS  C-KINASE 1  HEPATOCELLULAR-CARCINOMA  STEROL 12-ALPHA-HYDROXYLASE  DOWN-REGULATION  ER STRESS  KAPPA-B  RECEPTOR  ACTIVATION  GROWTH  
Polyphyllin I combined with doxorubicin shows chemosensitization effect in vivo and reduces immunotoxicity of doxorubicin 期刊论文
MOLECULAR & CELLULAR TOXICOLOGY, 2022, 卷号: 18, 期号: 3, 页码: 359-369
作者:  Zhu, Xiang;  Na, Xin;  Zeng, Yueqin;  Xu, Yangantai;  Chai, Dongya;  Yang, Huanzhi;  Miao, Jingqian;  Zhang, Yuan;  Yang, Fenghua;  Wang, Yuehu;  Zhou, Yiping
浏览  |  Adobe PDF(1889Kb)  |  收藏  |  浏览/下载：35/8  |  提交时间：2024/04/30
Polyphyllin I  Chemosensitization  Doxorubicin  Immunotoxicity  Hemolysis  BREAST-CANCER CELLS  SAPONIN  INHIBITION  RESISTANCE  CISPLATIN  
Synthesis and biological evaluation of (+)-paeoveitol derivatives as novel antidepressants 期刊论文
MEDICINAL CHEMISTRY RESEARCH, 2022, 卷号: 31, 期号: 11, 页码: 2045-2057
作者:  Li, Tian-Ze;  Huang, Xiao-Yan;  Sun, Jin-Jin;  Geng, Chang-An;  Zhang, Xue-Mei;  Chen, Ji-Jun
浏览  |  Adobe PDF(1234Kb)  |  收藏  |  浏览/下载：42/10  |  提交时间：2024/04/30
(+)-Paeoveitol derivatives  Antidepressant  Forced swimming test  Monoamine neurotransmitter  
Alisol B Alleviates Hepatocyte Lipid Accumulation and Lipotoxicity via Regulating RAR alpha-PPAR gamma-CD36 Cascade and Attenuates Non-Alcoholic Steatohepatitis in Mice 期刊论文
NUTRIENTS, 2022, 卷号: 14, 期号: 12, 页码: 2411
作者:  Zhao, Zhuohui;  Deng, Zhen-Tao;  Huang, Suling;  Ning, Mengmeng;  Feng, Ying;  Shen, Yu;  Zhao, Qin-Shi;  Leng, Ying
浏览  |  Adobe PDF(6451Kb)  |  收藏  |  浏览/下载：48/13  |  提交时间：2024/04/30
Alisol B  non-alcoholic steatohepatitis  RAR alpha  CD36  FATTY LIVER  HEPATIC STEATOSIS  RECEPTOR  ORIENTALE  LIPOPROTEINS  23-ACETATE  AGONIST  CD36  
Synthesis and biological evaluation of paeoveitol D derivatives as new melatonin receptor agonists with antidepressant activities 期刊论文
RSC MEDICINAL CHEMISTRY, 2022, 卷号: 13, 期号: 10, 页码: 1212-1224
作者:  Li, Tian-Ze;  Hu, Jing;  Sun, Jin-Jin;  Huang, Xiao-Yan;  Geng, Chang-An;  Liu, Shu-Bai;  Zhang, Xue-Mei;  Chen, Ji-Jun
浏览  |  Adobe PDF(932Kb)  |  收藏  |  浏览/下载：45/12  |  提交时间：2024/04/30
BENZOFURAN  
Isorhynchophylline ameliorates stress-induced emotional disorder and cognitive impairment with modulation of NMDA receptors 期刊论文
FRONTIERS IN NEUROSCIENCE, 2022, 卷号: 16, 页码: 1071068
作者:  Wang, Chen;  Zhu, Ming-Hao;  Sun, Na;  Shen, Wei;  Jiang, Ning;  Zhao, Qin-Shi;  Zhang, Yong-Xiang;  Huang, Yan;  Zhou, Wen-Xia
浏览  |  Adobe PDF(4973Kb)  |  收藏  |  浏览/下载：2/2  |  提交时间：2024/08/21
isorhynchophylline (PubChem CID  3037048)  corticosterone  long-term potentiation  chronic unpredictable mild stress  D-serine  NMDA receptors  CHRONIC MILD STRESS  DEPRESSION-LIKE BEHAVIORS  SYNAPTIC PLASTICITY  HIPPOCAMPAL PLASTICITY  DENTATE GYRUS  CORTICOSTERONE  MEMORY  BRAIN  RHYNCHOPHYLLINE  IMPROVES  
Small molecule QF84139 ameliorates cardiac hypertrophy via activating the AMPK signaling pathway 期刊论文
ACTA PHARMACOLOGICA SINICA, 2022, 卷号: 43, 期号: 3, 页码: 588-601
作者:  Li,Xu-xia;  Zhang,Peng;  Yang,Yang;  Wang,Jing-jing;  Zheng,Yan-jun;  Tan,Ji-liang;  Liu,Shen-yan;  Yan,Yong-ming;  Zhang,You-yi;  Cheng,Yong-xian;  Yang,Huang-tian
浏览  |  Adobe PDF(4052Kb)  |  收藏  |  浏览/下载：82/1  |  提交时间：2022/04/02
cardiac hypertrophy  pyrazine derivative  QF84139  phenylephrine  transverse aortic constriction  AMPK signaling pathway  PROTEIN-KINASE  MAMMALIAN TARGET  OVERLOAD  METFORMIN  MACROPHAGES  MECHANISMS  MEDICINE  ALPHA  CELLS  MODEL  
PXR mediates mifepristone-induced hepatomegaly in mice 期刊论文
ACTA PHARMACOLOGICA SINICA, 2022, 卷号: 43, 期号: 1, 页码: 146-156
作者:  Yao,Xin-peng;  Jiao,Ting-ying;  Jiang,Yi-ming;  Fan,Shi-cheng;  Zhao,Ying-yuan;  Yang,Xiao;  Gao,Yue;  Li,Fei;  Zhou,Yan-ying;  Chen,Pan-pan;  Huang,Min;  Bi,Hui-chang
浏览  |  Adobe PDF(4101Kb)  |  收藏  |  浏览/下载：105/2  |  提交时间：2022/04/02
mifepristone  hepatomegaly  pregnane X receptor (PXR)  yes-associated protein (YAP)