Isorhynchophylline ameliorates stress-induced emotional disorder and cognitive impairment with modulation of NMDA receptors

doi:10.3389/fnins.2022.1071068

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	Isorhynchophylline ameliorates stress-induced emotional disorder and cognitive impairment with modulation of NMDA receptors
	Wang, Chen; Zhu, Ming-Hao; Sun, Na; Shen, Wei; Jiang, Ning; Zhao, Qin-Shi; Zhang, Yong-Xiang; Huang, Yan; Zhou, Wen-Xia
	2022
发表期刊	FRONTIERS IN NEUROSCIENCE
卷号	16 页码:1071068
摘要	IntroductionIsorhynchophylline is one of the main active ingredients from Uncaria rhynchophylla, the effects and mechanisms of isorhynchophylline on stress-induced emotional disorders and cognitive impairment remain unclear. MethodsLong-term potentiation (LTP) in vivo was used for synaptic plasticity evaluation; chronic unpredictable mild stress (CUMS) model was used to evaluate the effect of isorhynchophylline on stress induced emotional disorders and cognitive impairment; sucrose preference test (SPT), open field test (OFT), and elevated plus maze (EPM) were used to evaluate emotional disorders; morris water maze (MWM) test was used to evaluate cognitive impairment; Western blotting (WB) was used to the expression of proteins; high performance liquid chromatography (HPLC) was used to quantify neurotransmitters; Nissl staining was used to identify pathological changes induced by stress. ResultsIn this study, we found that isorhynchophylline improved corticosterone-induced in vivo LTP impairment significantly, indicating positive effects on stress. Therefore, 28-day CUMS model was adopted to evaluate the anti-stress effects of isorhynchophylline. The results showed that isorhynchophylline improved CUMS-induced weight loss, anxiety- and depression-like behaviors, and spatial memory impairment. Isorhynchophylline reduced CUMS-induced corticosterone elevation. N-methyl-D-aspartic acid (NMDA) receptors play an important role in the process of emotion and memory. Glutamate and the expression of GluN2B increased in the CUMS mice, while D-serine and the expression of serine racemase (SR) decreased significantly, and isorhynchophylline restored these changes to normal level. ConclusionThese results indicated that isorhynchophylline ameliorated stress-induced emotional disorders and cognitive impairment, modulating NMDA receptors might be one of the underlying mechanisms.
关键词	isorhynchophylline (PubChem CID 3037048) corticosterone long-term potentiation chronic unpredictable mild stress D-serine NMDA receptors CHRONIC MILD STRESS DEPRESSION-LIKE BEHAVIORS SYNAPTIC PLASTICITY HIPPOCAMPAL PLASTICITY DENTATE GYRUS CORTICOSTERONE MEMORY BRAIN RHYNCHOPHYLLINE IMPROVES
DOI	10.3389/fnins.2022.1071068
收录类别	SCI
WOS记录号	WOS:000905494700001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75645
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Wang, Chen,Zhu, Ming-Hao,Sun, Na,et al. Isorhynchophylline ameliorates stress-induced emotional disorder and cognitive impairment with modulation of NMDA receptors[J]. FRONTIERS IN NEUROSCIENCE,2022,16:1071068.
APA	Wang, Chen.,Zhu, Ming-Hao.,Sun, Na.,Shen, Wei.,Jiang, Ning.,...&Zhou, Wen-Xia.(2022).Isorhynchophylline ameliorates stress-induced emotional disorder and cognitive impairment with modulation of NMDA receptors.FRONTIERS IN NEUROSCIENCE,16,1071068.
MLA	Wang, Chen,et al."Isorhynchophylline ameliorates stress-induced emotional disorder and cognitive impairment with modulation of NMDA receptors".FRONTIERS IN NEUROSCIENCE 16(2022):1071068.

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