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Design, Synthesis, and Biological Activities of Vibsanin B Derivatives: A New Class of HSP90 C-Terminal Inhibitors 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 21, 页码: 9053-9066
作者:  Shao, Li-Dong;  Su, Jia;  Ye, Baixin;  Liu, Jiang-Xin;  Zuo, Zhi-Li;  Li, Yan;  Wang, Yue-Ying;  Xia, Chengfeng;  Zhao, Qin-Shi
Adobe PDF(5724Kb)  |  收藏  |  浏览/下载：369/41  |  提交时间：2017/12/18
Manginoids A-G: Seven Monoterpene-Shikimate-Conjugated Meroterpenoids with a Spiro Ring System from Guignardia mangiferae 期刊论文
ORGANIC LETTERS, 2017, 卷号: 19, 期号: 21, 页码: 5956-5959
作者:  Chen, Keliang;  Zhang, Xuwen;  Sun, Weiguang;  Liu, Junjun;  Yang, Jing;  Chen, Chunmei;  Liu, Xiulan;  Gao, Limin;  Wang, Jianping;  Li, Hua;  Luo, Zengwei;  Xue, Yongbo;  Zhu, Hucheng;  Zhang, Yonghui
浏览  |  Adobe PDF(1771Kb)  |  收藏  |  浏览/下载：302/31  |  提交时间：2017/12/18
Natural Cyclopeptide RA-XII, a New Autophagy Inhibitor, Suppresses Protective Autophagy for Enhancing Apoptosis through AMPK/mTOR/P70S6K Pathways in HepG2 Cells 期刊论文
MOLECULES, 2017, 卷号: 22, 期号: 11, 页码: UNSP 1934
作者:  Song, Lihua;  Wang, Zhe;  Wang, Yurong;  Guo, Di;  Yang, Jianhong;  Chen, Lijuan;  Tan, Ninghua
浏览  |  Adobe PDF(4110Kb)  |  收藏  |  浏览/下载：139/31  |  提交时间：2018/05/08
Ra-xii  Cyclopeptide  Autophagy  Apoptosis  Mtor  Hepg2 Liver Cancer Cells  
Potential role of CYP1B1 in the development and treatment of metabolic diseases 期刊论文
PHARMACOLOGY & THERAPEUTICS, 2017, 卷号: 178, 页码: 18-30
作者:  Li, Fei;  Zhu, Weifeng;  Gonzalez, Frank J.
浏览  |  Adobe PDF(2083Kb)  |  收藏  |  浏览/下载：163/53  |  提交时间：2017/11/20
Cyp1b1  Metabolic Diseases  Metabolic Pathways  Metabolomics  
Aspirin increases metabolism through germline signalling to extend the lifespan of Caenorhabditis elegans 期刊论文
PLOS ONE, 2017, 卷号: 12, 期号: 9, 页码: e0184027
作者:  Huang, Xiao-Bing;  Mu, Xiao-Hui;  Wan, Qin-Li;  He, Xiao-Ming;  Wu, Gui-Sheng;  Luo, Huai-Rong
Adobe PDF(7049Kb)  |  收藏  |  浏览/下载：179/36  |  提交时间：2017/10/23
Nonsteroidal Antiinflammatory Drugs  Stem-cells  C. Elegans  Reproductive-system  Sodium-salicylate  Fat-metabolism  Kappa-b  Longevity  Acid  Disease  
PPAR alpha activation protects against cholestatic liver injury 期刊论文
SCIENTIFIC REPORTS, 2017, 卷号: 7, 页码: 9967
作者:  Zhao, Qi;  Yang, Rui;  Wang, Jing;  Hu, Dan-Dan;  Li, Fei
浏览  |  Adobe PDF(7693Kb)  |  收藏  |  浏览/下载：211/49  |  提交时间：2017/10/23
Primary Biliary-cirrhosis  Bile-acid Homeostasis  Receptor-alpha  Ursodeoxycholic Acid  Cholesterol 7-alpha-hydroxylase  Beta-oxidation  Fenofibrate  Therapy  Mice  Hepatotoxicity  
Borapetoside E, a Clerodane Diterpenoid Extracted from Tinospora crispa, Improves Hyperglycemia and Hyperlipidemia in High-Fat-Diet-Induced Type 2 Diabetes Mice 期刊论文
JOURNAL OF NATURAL PRODUCTS, 2017, 卷号: 80, 期号: 8, 页码: 2319-2327
作者:  Xu, Yuhui;  Niu, Yanfen;  Gao, Yuan;  Wang, Fang;  Qin, Wanying;  Lu, Yanting;  Hu, Jing;  Peng, Li;  Liu, Jikai;  Xiong, Wenyong
Adobe PDF(4940Kb)  |  收藏  |  浏览/下载：342/58  |  提交时间：2017/10/23
Insulin-resistance  Tuberculata Beumee  Metabolic Syndrome  Srebp  Liver  Cholesterol  Constituents  Homeostasis  Inhibition  Receptors  
Synthesis of selective 11 beta-HSD1 inhibitors based on dammarane scaffold 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 135, 页码: 324-338
作者:  Shao, Li-Dong;  Bao, Ying;  Shen, Yu;  Su, Jia;  Leng, Ying;  Zhao, Qin-Shi
Adobe PDF(1336Kb)  |  收藏  |  浏览/下载：298/68  |  提交时间：2017/07/31
11 Beta-hsd1 Inhibitor  Hupehenols  Dammarane  Sar  
Neoalbaconol inhibits angiogenesis and tumor growth by suppressing EGFR-mediated VEGF production 期刊论文
MOLECULAR CARCINOGENESIS, 2017, 卷号: 56, 期号: 5, 页码: 1414-1426
作者:  Yu, Xinfang;  Li, Wei;  Deng, Qipan;  You, Shuo;  Liu, Haidan;  Peng, Songling;  Liu, Xiaolan;  Lu, Jingchen;  Luo, Xiangjian;  Yang, Lifang;  Tang, Min;  Weng, Xinxian;  Yi, Wei;  Liu, Wenbin;  Wu, Shengqi;  Ding, Zhihui;  Feng, Tao;  Zhou, Jian;  Fan, Jia;  Bode, Ann M.;  Dong, Zigang;  Liu, Jikai;  Cao, Ya
Adobe PDF(6365Kb)  |  收藏  |  浏览/下载：297/101  |  提交时间：2017/06/30
Angiogenesis  Breast Cancer  Egfr  Neoalbaconol  Vegf  
1,4-Naphthoquinone Triggers Nematode Lethality by Inducing Oxidative Stress and Activating Insulin/IGF Signaling Pathway in Caenorhabditis elegans10.3390/molecules22050798 期刊论文
MOLECULES, 2017, 卷号: 22, 期号: 5, 页码: 798
作者:  Wang, Jia;  Zeng, Guangzhi;  Huang, Xiaobing;  Wang, Zhe;  Tan, Ninghua
Adobe PDF(3070Kb)  |  收藏  |  浏览/下载：165/28  |  提交时间：2017/07/31
Plant-parasitic Nematode  Phytochemical  Nematocidal  Oxidative Stress  1  Insulin/igf Signaling Pathway  4-naphthoquinone  Caenorhabditis Elegans