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题名: Borapetoside E, a Clerodane Diterpenoid Extracted from Tinospora crispa, Improves Hyperglycemia and Hyperlipidemia in High-Fat-Diet-Induced Type 2 Diabetes Mice
作者: Xu, Yuhui1, 2; Niu, Yanfen1, 2, 4; Gao, Yuan5, 6; Wang, Fang1, 2; Qin, Wanying1, 2; Lu, Yanting1, 2; Hu, Jing1, 2; Peng, Li1, 2; Liu, Jikai3; Xiong, Wenyong1, 2
刊名: JOURNAL OF NATURAL PRODUCTS
关键词: INSULIN-RESISTANCE ; TUBERCULATA BEUMEE ; METABOLIC SYNDROME ; SREBP ; LIVER ; CHOLESTEROL ; CONSTITUENTS ; HOMEOSTASIS ; INHIBITION ; RECEPTORS
英文摘要: An insidious increase in the incidence of obesity, insulin resistance, and hyperlipidemia has led to an epidemic of type 2 diabetes worldwide. Tinospora crispa (T. crispa,) is a familiar plant traditionally used in herbal medicine for diabetes; however, the major active ingredients of this plant are still unclear. In this study, we identified the therapeutic effects of borapetoside E, a small molecule extracted from T. crispa, in high-fat-diet (HFD)-induced obesity in mice. The therapeutic effects of borapetoside E in HFD-induced obese mice were assessed physiologically, histologically, and biochemically following intraperitoneal injection. Furthermore, we analyzed the expression of glucose and lipid metabolism-related genes and proteins in borapetoside E-treated obese mice. Compared with vehicle-treated mice, borapetoside E markedly improved hyperglycemia, insulin resistance, hepatic steatosis, hyperlipidemia, and oxygen consumption in obese mice, and the effects were comparable to or better than the drug metformin. In addition, borapetoside E suppressed the expression of sterol regulatory element binding proteins (SREBPs) and their downstream target genes related to lipid synthesis in the liver and adipose tissue. Borapetoside E showed beneficial effects in vivo, demonstrating that borapetoside E may be a potential therapy for the treatment of diet-induced type 2 diabetes and related metabolic syndromes.
出版日期: 2017-08-01
卷号: 80, 期号:8, 页码:2319-2327
DOI标识: 10.1021/acs.jnatprod.7b00365
语种: 英语
ISSN号: 0163-3864
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/54928
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Hubei, Peoples R China
4.Kunming Med Univ, Engn Res Ctr, Kunming 650500, Yunnan, Peoples R China
5.BioBioPha Co Ltd, Kunming 650201, Yunnan, Peoples R China
6.Yibin Univ, Dept Chem Engn, Yibin 644000, Peoples R China

Recommended Citation:
Xu,Yuhui,Niu,Yanfen,Gao,Yuan,et al. Borapetoside E, a Clerodane Diterpenoid Extracted from Tinospora crispa, Improves Hyperglycemia and Hyperlipidemia in High-Fat-Diet-Induced Type 2 Diabetes Mice[J]. JOURNAL OF NATURAL PRODUCTS,2017,80(8):2319-2327.
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文件名: 10.1021@acs.jnatprod.7b00365.pdf
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