Borapetoside E, a Clerodane Diterpenoid Extracted from Tinospora crispa, Improves Hyperglycemia and Hyperlipidemia in High-Fat-Diet-Induced Type 2 Diabetes Mice
Xu, Yuhui1,2; Niu, Yanfen1,2,4; Gao, Yuan5,6; Wang, Fang1,2; Qin, Wanying1,2; Lu, Yanting1,2; Hu, Jing1,2; Peng, Li1,2; Liu, Jikai3; Xiong, Wenyong1,2
2017-08-01
Source PublicationJOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
Volume80Issue:8Pages:2319-2327
AbstractAn insidious increase in the incidence of obesity, insulin resistance, and hyperlipidemia has led to an epidemic of type 2 diabetes worldwide. Tinospora crispa (T. crispa,) is a familiar plant traditionally used in herbal medicine for diabetes; however, the major active ingredients of this plant are still unclear. In this study, we identified the therapeutic effects of borapetoside E, a small molecule extracted from T. crispa, in high-fat-diet (HFD)-induced obesity in mice. The therapeutic effects of borapetoside E in HFD-induced obese mice were assessed physiologically, histologically, and biochemically following intraperitoneal injection. Furthermore, we analyzed the expression of glucose and lipid metabolism-related genes and proteins in borapetoside E-treated obese mice. Compared with vehicle-treated mice, borapetoside E markedly improved hyperglycemia, insulin resistance, hepatic steatosis, hyperlipidemia, and oxygen consumption in obese mice, and the effects were comparable to or better than the drug metformin. In addition, borapetoside E suppressed the expression of sterol regulatory element binding proteins (SREBPs) and their downstream target genes related to lipid synthesis in the liver and adipose tissue. Borapetoside E showed beneficial effects in vivo, demonstrating that borapetoside E may be a potential therapy for the treatment of diet-induced type 2 diabetes and related metabolic syndromes.
KeywordInsulin-resistance Tuberculata Beumee Metabolic Syndrome Srebp Liver Cholesterol Constituents Homeostasis Inhibition Receptors
Subject AreaPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1021/acs.jnatprod.7b00365
Indexed BySCI
Language英语
WOS IDWOS:000408702600016
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/54928
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Hubei, Peoples R China
4.Kunming Med Univ, Engn Res Ctr, Kunming 650500, Yunnan, Peoples R China
5.BioBioPha Co Ltd, Kunming 650201, Yunnan, Peoples R China
6.Yibin Univ, Dept Chem Engn, Yibin 644000, Peoples R China
Recommended Citation
GB/T 7714
Xu, Yuhui,Niu, Yanfen,Gao, Yuan,et al. Borapetoside E, a Clerodane Diterpenoid Extracted from Tinospora crispa, Improves Hyperglycemia and Hyperlipidemia in High-Fat-Diet-Induced Type 2 Diabetes Mice[J]. JOURNAL OF NATURAL PRODUCTS,2017,80(8):2319-2327.
APA Xu, Yuhui.,Niu, Yanfen.,Gao, Yuan.,Wang, Fang.,Qin, Wanying.,...&Xiong, Wenyong.(2017).Borapetoside E, a Clerodane Diterpenoid Extracted from Tinospora crispa, Improves Hyperglycemia and Hyperlipidemia in High-Fat-Diet-Induced Type 2 Diabetes Mice.JOURNAL OF NATURAL PRODUCTS,80(8),2319-2327.
MLA Xu, Yuhui,et al."Borapetoside E, a Clerodane Diterpenoid Extracted from Tinospora crispa, Improves Hyperglycemia and Hyperlipidemia in High-Fat-Diet-Induced Type 2 Diabetes Mice".JOURNAL OF NATURAL PRODUCTS 80.8(2017):2319-2327.
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