| Aspirin increases metabolism through germline signalling to extend the lifespan of Caenorhabditis elegans | |
Huang, Xiao-Bing1; Mu, Xiao-Hui2,3,4; Wan, Qin-Li1; He, Xiao-Ming1; Wu, Gui-Sheng1 ; Luo, Huai-Rong1,2,3
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| 2017-09-14 | |
| 发表期刊 | PLOS ONE
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| ISSN | 1932-6203 |
| 卷号 | 12期号:9页码:e0184027 |
| 摘要 | Aspirin is a prototypic cyclooxygenase inhibitor with a variety of beneficial effects on human health. It prevents age-related diseases and delays the aging process. Previous research has shown that aspirin might act through a dietary restriction-like mechanism to extend lifespan. To explore the mechanism of action of aspirin on aging, we determined the wholegenome expression profile of Caenorhabditis elegans treated with aspirin. Transcriptome analysis revealed the RNA levels of genes involved in metabolism were primarily increased. Reproduction has been reported to be associated with metabolism. We found that aspirin did not extend the lifespan or improve the heat stress resistance of germline mutants of glp1. Furthermore, Oil Red O staining showed that aspirin treatment decreased lipid deposition and increased expression of lipid hydrolysis and fatty acid beta-oxidation-related genes. The effect of germline ablation on lifespan was mainly mediated by DAF-12 and DAF-16. Next, we performed genetic analysis with a series of worm mutants and found that aspirin did not further extend the lifespans of daf-12 and daf-16 single mutants, glp-1; daf-12 and glp-1; daf16 double mutants, or glp-1; daf-12; daf-16 triple mutants. The results suggest that aspirin increase metabolism and regulate germline signalling to activate downstream DAF-12 and DAF-16 to extend lifespan. |
| 关键词 | Nonsteroidal Antiinflammatory Drugs Stem-cells C. Elegans Reproductive-system Sodium-salicylate Fat-metabolism Kappa-b Longevity Acid Disease |
| 学科领域 | Multidisciplinary Sciences |
| DOI | 10.1371/journal.pone.0184027 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000410859200027 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/54883 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Southwest Med Univ, Sch Pharm, Dept Pharmacol, Key Lab Aging & Regenerat Med, Luzhou, Sichuan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming, Yunnan, Peoples R China 4.Univ Chinese Acad Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Xiao-Bing,Mu, Xiao-Hui,Wan, Qin-Li,et al. Aspirin increases metabolism through germline signalling to extend the lifespan of Caenorhabditis elegans[J]. PLOS ONE,2017,12(9):e0184027. |
| APA | Huang, Xiao-Bing,Mu, Xiao-Hui,Wan, Qin-Li,He, Xiao-Ming,Wu, Gui-Sheng,&Luo, Huai-Rong.(2017).Aspirin increases metabolism through germline signalling to extend the lifespan of Caenorhabditis elegans.PLOS ONE,12(9),e0184027. |
| MLA | Huang, Xiao-Bing,et al."Aspirin increases metabolism through germline signalling to extend the lifespan of Caenorhabditis elegans".PLOS ONE 12.9(2017):e0184027. |
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