Potential role of CYP1B1 in the development and treatment of metabolic diseases
Li, Fei1,2; Zhu, Weifeng3; Gonzalez, Frank J.1
2017-10-01
Source PublicationPHARMACOLOGY & THERAPEUTICS
ISSN0163-7258
Volume178Pages:18-30
AbstractCytochrome P450 1B1 (CYP1B1), a member of CYP superfamily, is expressed in liver and extrahepatic tissues carries out the metabolism of numerous xenobiotics, including metabolic activation of polycyclic aromatic hydrocarbons. Surprisingly, CYP1B1 was also shown to be important in regulating endogenous metabolic pathways, including the metabolism of steroid hormones, fatty acids, melatonin, and vitamins. CYP1B1 and nuclear receptors including peroxisome proliferator-activated receptors (PPARs), estrogen receptor (ER), and retinoic acid receptors (RAR) contribute to the maintenance of the homeostasis of these endogenous compounds. Many natural flavonoids and synthetic stilbenes show inhibitory activity toward CYP1B1 expression and function, notably isorhamnetin and 2,4,3 ',5 '-tetramethoxystilbene. Accumulating evidence indicates that modulation of CYP1B1 can decrease adipogenesis and tumorigenesis, and prevent obesity, hypertension, atherosclerosis, and cancer. Therefore, it may be feasible to consider CYP1B1 as a therapeutic target for the treatment of metabolic diseases. Published by Elsevier Inc.
KeywordCyp1b1 Metabolic Diseases Metabolic Pathways Metabolomics
DOI10.1016/j.pharmthera.2017.03.007
Language英语
WOS IDWOS:000412789100002
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Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/54997
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.NCI, Lab Metab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA
2.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
3.Jiangxi Univ Tradit Chinese Med, Res Ctr Differentiat & Dev Basic Theory Tradit Ch, Nanchang 330004, Jiangxi, Peoples R China
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GB/T 7714
Li, Fei,Zhu, Weifeng,Gonzalez, Frank J.. Potential role of CYP1B1 in the development and treatment of metabolic diseases[J]. PHARMACOLOGY & THERAPEUTICS,2017,178:18-30.
APA Li, Fei,Zhu, Weifeng,&Gonzalez, Frank J..(2017).Potential role of CYP1B1 in the development and treatment of metabolic diseases.PHARMACOLOGY & THERAPEUTICS,178,18-30.
MLA Li, Fei,et al."Potential role of CYP1B1 in the development and treatment of metabolic diseases".PHARMACOLOGY & THERAPEUTICS 178(2017):18-30.
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