Potential role of CYP1B1 in the development and treatment of metabolic diseases

doi:10.1016/j.pharmthera.2017.03.007

	Potential role of CYP1B1 in the development and treatment of metabolic diseases
	Li, Fei 1,2; Zhu, Weifeng 3; Gonzalez, Frank J.1
	2017-10-01
发表期刊	PHARMACOLOGY & THERAPEUTICS
ISSN	0163-7258
卷号	178 页码:18-30
摘要	Cytochrome P450 1B1 (CYP1B1), a member of CYP superfamily, is expressed in liver and extrahepatic tissues carries out the metabolism of numerous xenobiotics, including metabolic activation of polycyclic aromatic hydrocarbons. Surprisingly, CYP1B1 was also shown to be important in regulating endogenous metabolic pathways, including the metabolism of steroid hormones, fatty acids, melatonin, and vitamins. CYP1B1 and nuclear receptors including peroxisome proliferator-activated receptors (PPARs), estrogen receptor (ER), and retinoic acid receptors (RAR) contribute to the maintenance of the homeostasis of these endogenous compounds. Many natural flavonoids and synthetic stilbenes show inhibitory activity toward CYP1B1 expression and function, notably isorhamnetin and 2,4,3 ',5 '-tetramethoxystilbene. Accumulating evidence indicates that modulation of CYP1B1 can decrease adipogenesis and tumorigenesis, and prevent obesity, hypertension, atherosclerosis, and cancer. Therefore, it may be feasible to consider CYP1B1 as a therapeutic target for the treatment of metabolic diseases. Published by Elsevier Inc.
关键词	Cyp1b1 Metabolic Diseases Metabolic Pathways Metabolomics
DOI	10.1016/j.pharmthera.2017.03.007
语种	英语
WOS记录号	WOS:000412789100002
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/54997
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.NCI, Lab Metab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA 2.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China 3.Jiangxi Univ Tradit Chinese Med, Res Ctr Differentiat & Dev Basic Theory Tradit Ch, Nanchang 330004, Jiangxi, Peoples R China
推荐引用方式 GB/T 7714	Li, Fei,Zhu, Weifeng,Gonzalez, Frank J.. Potential role of CYP1B1 in the development and treatment of metabolic diseases[J]. PHARMACOLOGY & THERAPEUTICS,2017,178:18-30.
APA	Li, Fei,Zhu, Weifeng,&Gonzalez, Frank J..(2017).Potential role of CYP1B1 in the development and treatment of metabolic diseases.PHARMACOLOGY & THERAPEUTICS,178,18-30.
MLA	Li, Fei,et al."Potential role of CYP1B1 in the development and treatment of metabolic diseases".PHARMACOLOGY & THERAPEUTICS 178(2017):18-30.

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