Manginoids A-G: Seven Monoterpene-Shikimate-Conjugated Meroterpenoids with a Spiro Ring System from Guignardia mangiferae
Chen, Keliang1; Zhang, Xuwen3; Sun, Weiguang1; Liu, Junjun1; Yang, Jing4; Chen, Chunmei1; Liu, Xiulan2; Gao, Limin1; Wang, Jianping1; Li, Hua1; Luo, Zengwei1; Xue, Yongbo1; Zhu, Hucheng1; Zhang, Yonghui1
2017-11-03
发表期刊ORGANIC LETTERS
ISSN1523-7060
卷号19期号:21页码:5956-5959
摘要Manginoids A-G (1-7), seven monoterpene-shikimate-conjugated meroterpenoids with a spiro ring system, were isolated from Guignardia mangiferae. Compounds 1-4 are four isomers with epimeric and double-bond isomeric features possessing a 6-oxaspiro[bicyclo[3.2.1]octane-3,5 '-indene] ring, which represent the first examples of spiro meroterpenoids bearing a bridged spirocyclohexanedione moiety. Compounds 5 and 6 possess an unexpected 2,4-dioxatricyclo[3.3.1.0(3,7)]nonane motif, which fuses with a 6-oxabicyclo[3.2.1]octane moiety. Compound 1 exhibits inhibitory activities against 11 beta-hydroxysteroid dehydrogenase type 1 with an IC50 value of 0.84 mu M.
语种英语
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/60374
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China
2.Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Wuhan 430030, Hubei, Peoples R China
3.Humanwell Healthcare Grp Co Ltd, Wuhan 430073, Hubei, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China
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Chen, Keliang,Zhang, Xuwen,Sun, Weiguang,et al. Manginoids A-G: Seven Monoterpene-Shikimate-Conjugated Meroterpenoids with a Spiro Ring System from Guignardia mangiferae[J]. ORGANIC LETTERS,2017,19(21):5956-5959.
APA Chen, Keliang.,Zhang, Xuwen.,Sun, Weiguang.,Liu, Junjun.,Yang, Jing.,...&Zhang, Yonghui.(2017).Manginoids A-G: Seven Monoterpene-Shikimate-Conjugated Meroterpenoids with a Spiro Ring System from Guignardia mangiferae.ORGANIC LETTERS,19(21),5956-5959.
MLA Chen, Keliang,et al."Manginoids A-G: Seven Monoterpene-Shikimate-Conjugated Meroterpenoids with a Spiro Ring System from Guignardia mangiferae".ORGANIC LETTERS 19.21(2017):5956-5959.
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