Manginoids A-G: Seven Monoterpene-Shikimate-Conjugated Meroterpenoids with a Spiro Ring System from Guignardia mangiferae

doi:10.1021/acs.orglett.7b02955

	Manginoids A-G: Seven Monoterpene-Shikimate-Conjugated Meroterpenoids with a Spiro Ring System from Guignardia mangiferae
	Chen, Keliang 1; Zhang, Xuwen 3; Sun, Weiguang 1; Liu, Junjun 1; Yang, Jing4 ; Chen, Chunmei 1; Liu, Xiulan 2; Gao, Limin 1; Wang, Jianping 1; Li, Hua 1; Luo, Zengwei 1; Xue, Yongbo 1; Zhu, Hucheng 1; Zhang, Yonghui 1
	2017-11-03
发表期刊	ORGANIC LETTERS
ISSN	1523-7060
卷号	19 期号:21 页码:5956-5959
摘要	Manginoids A-G (1-7), seven monoterpene-shikimate-conjugated meroterpenoids with a spiro ring system, were isolated from Guignardia mangiferae. Compounds 1-4 are four isomers with epimeric and double-bond isomeric features possessing a 6-oxaspiro[bicyclo[3.2.1]octane-3,5 '-indene] ring, which represent the first examples of spiro meroterpenoids bearing a bridged spirocyclohexanedione moiety. Compounds 5 and 6 possess an unexpected 2,4-dioxatricyclo[3.3.1.0(3,7)]nonane motif, which fuses with a 6-oxabicyclo[3.2.1]octane moiety. Compound 1 exhibits inhibitory activities against 11 beta-hydroxysteroid dehydrogenase type 1 with an IC50 value of 0.84 mu M.
DOI	10.1021/acs.orglett.7b02955
语种	英语
引用统计	被引频次：20[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/60374
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China 2.Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Wuhan 430030, Hubei, Peoples R China 3.Humanwell Healthcare Grp Co Ltd, Wuhan 430073, Hubei, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Chen, Keliang,Zhang, Xuwen,Sun, Weiguang,et al. Manginoids A-G: Seven Monoterpene-Shikimate-Conjugated Meroterpenoids with a Spiro Ring System from Guignardia mangiferae[J]. ORGANIC LETTERS,2017,19(21):5956-5959.
APA	Chen, Keliang.,Zhang, Xuwen.,Sun, Weiguang.,Liu, Junjun.,Yang, Jing.,...&Zhang, Yonghui.(2017).Manginoids A-G: Seven Monoterpene-Shikimate-Conjugated Meroterpenoids with a Spiro Ring System from Guignardia mangiferae.ORGANIC LETTERS,19(21),5956-5959.
MLA	Chen, Keliang,et al."Manginoids A-G: Seven Monoterpene-Shikimate-Conjugated Meroterpenoids with a Spiro Ring System from Guignardia mangiferae".ORGANIC LETTERS 19.21(2017):5956-5959.

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