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New Monoterpenoid Indole Alkaloids from Tabernaemontana crassa Inhibit beta-Amyloid42 Production and Phospho-Tau (Thr217) 期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 卷号: 24, 期号: 2, 页码: 1487
作者:  Li,Sheng;  Han,Ling-Ling;  Huang,Ke-Pu;  Ma,Ye-Han;  Guo,Ling-Li;  Guo,Yarong;  Ran,Xiaoqian;  Yao,Yong-Gang;  Hao,Xiao-Jiang;  Luo,Rongcan;  Zhang,Yu
浏览  |  Adobe PDF(5266Kb)  |  收藏  |  浏览/下载：5/3  |  提交时间：2024/05/09
Tabernaemontana crassa  monoterpenoid indole alkaloids  A beta 42  phospho-tau (Thr217)  Alzheimer's disease  ALZHEIMERS-DISEASE  BISINDOLE ALKALOIDS  CDK5  GEMFIBROZIL  PREVENTION  ALGORITHM  AUTOPHAGY  MODELS  PLANTS  MOUSE  
Cytostatic Activity of Sanguinarine and a Cyanide Derivative in Human Erythroleukemia Cells Is Mediated by Suppression of c-MET/MAPK Signaling 期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 卷号: 24, 期号: 9, 页码: 8113
作者:  Xu,Xinglian;  Deng,Lulu;  Tang,Yaling;  Li,Jiang;  Zhong,Ting;  Hao,Xiaojiang;  Fan,Yanhua;  Mu,Shuzhen
浏览  |  Adobe PDF(5829Kb)  |  收藏  |  浏览/下载：6/3  |  提交时间：2024/05/09
leukemia  sanguinarine  c-MET  MAPK  PI3K/mTOR  STAT3  MET  
Jatrophane Diterpenoids from Euphorbia peplus Linn. as Activators of Autophagy and Inhibitors of Tau Pathology 期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 卷号: 24, 期号: 2, 页码: 1088
作者:  Yan,Ying;  Zhou,Qi;  Ran,Xiaoqian;  Lu,Qingyun;  Zhang,Cuishan;  Peng,Mingyou;  Tang,Lei;  Luo,Rongcan;  Di,Yingtong;  Hao,Xiaojiang
浏览  |  Adobe PDF(11343Kb)  |  收藏  |  浏览/下载：5/2  |  提交时间：2024/05/09
euphjatrophane  Euphorbia peplus  jatrophane diterpenoid  autophagy  Tau pathology  UBIQUITIN-PROTEASOME SYSTEM  MULTIDRUG-RESISTANCE  BIOLOGICAL-ACTIVITY  ALZHEIMERS-DISEASE  MODULATORS  CELLS  
Novel nucleocapsid protein-targeting phenanthridine inhibitors of SARS-CoV-2 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 227, 页码: 113966
作者:  Wang,Yi-Ting;  Long,Xin-Yan;  Ding,Xiao;  Fan,Shi-Rui;  Cai,Jie-Yun;  Yang,Bi-Juan;  Zhang,Xin-Fang;  Luo,Rong-hua;  Yang,Lian;  Ruan,Ting;  Ren,Juan;  Jing,Chen-Xu;  Zheng,Yong-Tang;  Hao,Xiao-Jiang;  Chen,Duo-Zhi
收藏  |  浏览/下载：117/0  |  提交时间：2022/04/02
Phenanthridine  Nucleocapsid protein  SARS-CoV-2  N-terminal domain  N-TERMINAL DOMAIN  CORONAVIRUS  
Tabernaesine J, a Novel Vincamine-Type Indole Alkaloid with 6/5/6/6/6/5/5 Heptacyclic-Ring System Scaffold from Tabernaemontana pachysiphon 期刊论文
CHINESE JOURNAL OF CHEMISTRY, 2022, 卷号: 40, 期号: 4, 页码: 475-479
作者:  Yi,Wen-Fang;  Adelakun,Tiwalade A.;  Bai,Xue;  Zhang,Yu;  Hao,Xiao-Jiang
Adobe PDF(1252Kb)  |  收藏  |  浏览/下载：132/46  |  提交时间：2022/04/02
Natural products  Alkaloids  Structure elucidation  Tabernaemontana pachysiphon  Tabernaesine J  BISINDOLE ALKALOIDS  A-I  ALGORITHM  
Hyperpatone A, a polycyclic polyprenylated acylphloroglucinol with a rare 8/6/5/6/5 pentacyclic skeleton from Hypericum patulum 期刊论文
ORGANIC & BIOMOLECULAR CHEMISTRY, 2022, 卷号: 21, 期号: 1, 页码: 140-146
作者:  Zhang, Feng;  Yang, Jue;  Yi, Ping;  Li, Ya-Nan;  Hao, Xiao-Jiang;  Yuan, Chun-Mao
Adobe PDF(754Kb)  |  收藏  |  浏览/下载：11/2  |  提交时间：2024/04/30
ASSISTED STRUCTURE ELUCIDATION  
Two new seco-polycyclic polyprenylated acylphloroglucinol from Hypericum sampsonii 期刊论文
ORGANIC & BIOMOLECULAR CHEMISTRY, 2021, 卷号: 19, 期号: 1, 页码: 216-219
作者:  Zhang,Zi-Zhen;  Zeng,Yan-Rong;  Li,Ya-Nan;  Hu,Zhan-Xing;  Huang,Lie-Jun;  Gu,Wei;  Hao,Xiao-Jiang;  Yuan,Chun-Mao
收藏  |  浏览/下载：59/0  |  提交时间：2022/04/02
ASSISTED STRUCTURE ELUCIDATION  DERIVATIVES  
Acylphloroglucinols with acetylcholinesterase inhibitory effects from the fruits of Eucalyptus robusta (vol 103, 104127, 2020) 期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 108, 页码: 104579
作者:  Liu,Hui;  He,Xiao-Zhi;  Feng,Mi-Yan;  Zeng,Yuan;  Rauwolf,Tyler J.;  Shao,Li-Dong;  Ni,Wei;  Yan,Hui;  Porco,John A.,Jr.;  Hao,Xiao-Jiang;  Qin,Xu-Jie;  Liu,Hai-Yang
收藏  |  浏览/下载：62/0  |  提交时间：2022/04/02
Phylogenetic patterns suggest frequent multiple origins of secondary metabolites across the seed-plant 'tree of life' 期刊论文
NATIONAL SCIENCE REVIEW, 2021, 卷号: 8, 期号: 4, 页码: nwaa105
作者:  Zhang,Yongzeng;  Deng,Tao;  Sun,Lu;  Landis,Jacob B.;  Moore,Michael J.;  Wang,Hengchang;  Wang,Yuehua;  Hao,Xiaojiang;  Chen,Jijun;  Li,Shenghong;  Xu,Maonian;  Puno,Pema-Tenzin;  Raven,Peter H.;  Sun,Hang
收藏  |  浏览/下载：102/0  |  提交时间：2022/04/02
secondary metabolites  phylogenetic tree  phylogenetic signal  co-diversification  evolution  bioprospecting  seed plants  DIVERSIFICATION  EVOLUTION  DIVERSITY  SIGNAL  ANGIOSPERMS  CHEMISTRY  DEFENSES  FOSSIL  KEYS  
Diterpenoids with an unprecedented ring system from Euphorbia peplus and their activities in the lysosomal-autophagy pathway 期刊论文
ORGANIC & BIOMOLECULAR CHEMISTRY, 2021, 卷号: 19, 期号: 7, 页码: 1541-1545
作者:  Chen,Yan-Ni;  Ding,Xiao;  Li,Dong-Mei;  Sun,Mao;  Yang,Lei;  Zhang,Yu;  Di,Ying-Tong;  Fang,Xin;  Hao,Xiao-Jiang
Adobe PDF(1835Kb)  |  收藏  |  浏览/下载：83/17  |  提交时间：2022/04/02