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Two new seco-polycyclic polyprenylated acylphloroglucinol from Hypericum sampsonii
Zhang,Zi-Zhen; Zeng,Yan-Rong; Li,Ya-Nan; Hu,Zhan-Xing; Huang,Lie-Jun; Gu,Wei; Hao,Xiao-Jiang; Yuan,Chun-Mao
2021
Source PublicationORGANIC & BIOMOLECULAR CHEMISTRY
ISSN1477-0520
Volume19Issue:1Pages:216-219
AbstractHypsampsone A (1) and hyperhexanone F (2), two novel seco-polycyclic polyprenylated acylphloroglucinols, were isolated from Hypericum sampsonii. Hypsampsone A (1) features the first spirocyclic system fused with 5/6/5/5 tetracyclic skeleton. Hyperhexanone F (2) represents the second novel 1,2-seco-bicyclo[3.3.1]-PPAP skeleton. Their structures were established by extensive spectroscopic analysis, computer-assisted structure elucidation software, and calculated electronic circular dichroism spectra. A plausible biogenetic pathway of 1 was also proposed. Compounds 1 and 2 showed moderate multidrug resistance reversal activity to adriamycin (ADR) resistant cancer cell lines, HepG2/ADR and MCF-7/ADR, with the fold-reversals ranging from 16 to 38 at noncytotoxic concentration of 10 mu M.
KeywordASSISTED STRUCTURE ELUCIDATION DERIVATIVES
DOI10.1039/d0ob02072a
WOS IDWOS:000607351800018
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/73653
Collection中国科学院昆明植物研究所
Affiliation1.[Zhang, Zi-Zhen
2.Zeng, Yan-Rong
3.Li, Ya-Nan
4.Hu, Zhan-Xing
5.Huang, Lie-Jun
6.Gu, Wei
7.Hao, Xiao-Jiang
8.Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guiyang 550014, Peoples R China
9.Guizhou Med Univ, Sch Pharmaceut Sci, Guiyang 550025, Peoples R China
10.Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550014, Peoples R China
11.Chinese Acad Sci, Guiyang 550014, Peoples R China
12.Chinese Acad Sci, Kunming Inst Boanty, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Zhang,Zi-Zhen,Zeng,Yan-Rong,Li,Ya-Nan,et al. Two new seco-polycyclic polyprenylated acylphloroglucinol from Hypericum sampsonii[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2021,19(1):216-219.
APA Zhang,Zi-Zhen.,Zeng,Yan-Rong.,Li,Ya-Nan.,Hu,Zhan-Xing.,Huang,Lie-Jun.,...&Yuan,Chun-Mao.(2021).Two new seco-polycyclic polyprenylated acylphloroglucinol from Hypericum sampsonii.ORGANIC & BIOMOLECULAR CHEMISTRY,19(1),216-219.
MLA Zhang,Zi-Zhen,et al."Two new seco-polycyclic polyprenylated acylphloroglucinol from Hypericum sampsonii".ORGANIC & BIOMOLECULAR CHEMISTRY 19.1(2021):216-219.
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