Tabernaesine J, a Novel Vincamine-Type Indole Alkaloid with 6/5/6/6/6/5/5 Heptacyclic-Ring System Scaffold from Tabernaemontana pachysiphon

doi:10.1002/cjoc.202100634

KIB OpenIR

	Tabernaesine J, a Novel Vincamine-Type Indole Alkaloid with 6/5/6/6/6/5/5 Heptacyclic-Ring System Scaffold from Tabernaemontana pachysiphon
	Yi,Wen-Fang ; Adelakun,Tiwalade A.; Bai,Xue ; Zhang,Yu; Hao,Xiao-Jiang
	2022
Source Publication	CHINESE JOURNAL OF CHEMISTRY
ISSN	1001-604X
Volume	40 Issue:4 Pages:475-479
Abstract	Comprehensive Summary Tabernaesine J (1), an unprecedented vincamine-type indole alkaloid with 6/5/6/6/6/5/5 heptacyclic-ring system, as well as one new biogenetically related vincamine-type indole alkaloid (2), were isolated from leaves of Tabernaemontana pachysiphon. Their structures were established by a combination of HRESIMS, NMR, single crystal X-ray diffraction, and ECD calculation. The unprecedented penta-lactone ring in tabernaesine J (1) was postulated to be derived from acetyl-CoA enolate anion. Alkaloid 2 combined with fluconazole has the potential to overcome fluconazole resistance in Candida albicans.
Keyword	Natural products Alkaloids Structure elucidation Tabernaemontana pachysiphon Tabernaesine J BISINDOLE ALKALOIDS A-I ALGORITHM
DOI	10.1002/cjoc.202100634
WOS ID	WOS:000733237000001
Citation statistics
Document Type	期刊论文
Identifier	http://ir.kib.ac.cn/handle/151853/73045
Collection	中国科学院昆明植物研究所
Affiliation	1.[Yi, Wen-Fang 2.Adelakun, Tiwalade A. 3.Bai, Xue 4.Zhang, Yu 5.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
Recommended Citation GB/T 7714	Yi,Wen-Fang,Adelakun,Tiwalade A.,Bai,Xue,et al. Tabernaesine J, a Novel Vincamine-Type Indole Alkaloid with 6/5/6/6/6/5/5 Heptacyclic-Ring System Scaffold from Tabernaemontana pachysiphon[J]. CHINESE JOURNAL OF CHEMISTRY,2022,40(4):475-479.
APA	Yi,Wen-Fang,Adelakun,Tiwalade A.,Bai,Xue,Zhang,Yu,&Hao,Xiao-Jiang.(2022).Tabernaesine J, a Novel Vincamine-Type Indole Alkaloid with 6/5/6/6/6/5/5 Heptacyclic-Ring System Scaffold from Tabernaemontana pachysiphon.CHINESE JOURNAL OF CHEMISTRY,40(4),475-479.
MLA	Yi,Wen-Fang,et al."Tabernaesine J, a Novel Vincamine-Type Indole Alkaloid with 6/5/6/6/6/5/5 Heptacyclic-Ring System Scaffold from Tabernaemontana pachysiphon".CHINESE JOURNAL OF CHEMISTRY 40.4(2022):475-479.

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