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Tabernaesine J, a Novel Vincamine-Type Indole Alkaloid with 6/5/6/6/6/5/5 Heptacyclic-Ring System Scaffold from Tabernaemontana pachysiphon | |
Yi,Wen-Fang; Adelakun,Tiwalade A.; Bai,Xue; Zhang,Yu![]() ![]() | |
2022 | |
Source Publication | CHINESE JOURNAL OF CHEMISTRY
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ISSN | 1001-604X |
Volume | 40Issue:4Pages:475-479 |
Abstract | Comprehensive Summary Tabernaesine J (1), an unprecedented vincamine-type indole alkaloid with 6/5/6/6/6/5/5 heptacyclic-ring system, as well as one new biogenetically related vincamine-type indole alkaloid (2), were isolated from leaves of Tabernaemontana pachysiphon. Their structures were established by a combination of HRESIMS, NMR, single crystal X-ray diffraction, and ECD calculation. The unprecedented penta-lactone ring in tabernaesine J (1) was postulated to be derived from acetyl-CoA enolate anion. Alkaloid 2 combined with fluconazole has the potential to overcome fluconazole resistance in Candida albicans. |
Keyword | Natural products Alkaloids Structure elucidation Tabernaemontana pachysiphon Tabernaesine J BISINDOLE ALKALOIDS A-I ALGORITHM |
DOI | 10.1002/cjoc.202100634 |
WOS ID | WOS:000733237000001 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.kib.ac.cn/handle/151853/73045 |
Collection | 中国科学院昆明植物研究所 |
Affiliation | 1.[Yi, Wen-Fang 2.Adelakun, Tiwalade A. 3.Bai, Xue 4.Zhang, Yu 5.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China |
Recommended Citation GB/T 7714 | Yi,Wen-Fang,Adelakun,Tiwalade A.,Bai,Xue,et al. Tabernaesine J, a Novel Vincamine-Type Indole Alkaloid with 6/5/6/6/6/5/5 Heptacyclic-Ring System Scaffold from Tabernaemontana pachysiphon[J]. CHINESE JOURNAL OF CHEMISTRY,2022,40(4):475-479. |
APA | Yi,Wen-Fang,Adelakun,Tiwalade A.,Bai,Xue,Zhang,Yu,&Hao,Xiao-Jiang.(2022).Tabernaesine J, a Novel Vincamine-Type Indole Alkaloid with 6/5/6/6/6/5/5 Heptacyclic-Ring System Scaffold from Tabernaemontana pachysiphon.CHINESE JOURNAL OF CHEMISTRY,40(4),475-479. |
MLA | Yi,Wen-Fang,et al."Tabernaesine J, a Novel Vincamine-Type Indole Alkaloid with 6/5/6/6/6/5/5 Heptacyclic-Ring System Scaffold from Tabernaemontana pachysiphon".CHINESE JOURNAL OF CHEMISTRY 40.4(2022):475-479. |
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057-E05-050-张于-CJC.p(1252KB) | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Application Full Text |
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