Cytostatic Activity of Sanguinarine and a Cyanide Derivative in Human Erythroleukemia Cells Is Mediated by Suppression of c-MET/MAPK Signaling

doi:10.3390/ijms24098113

KIB OpenIR

	Cytostatic Activity of Sanguinarine and a Cyanide Derivative in Human Erythroleukemia Cells Is Mediated by Suppression of c-MET/MAPK Signaling
	Xu,Xinglian; Deng,Lulu; Tang,Yaling; Li,Jiang; Zhong,Ting; Hao,Xiaojiang; Fan,Yanhua; Mu,Shuzhen
	2023
发表期刊	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
ISSN	1422-0067
卷号	24 期号:9 页码:8113
摘要	Sanguinarine (1) is a natural product with significant pharmacological effects. However, the application of sanguinarine has been limited due to its toxic side effects and a lack of clarity regarding its molecular mechanisms. To reduce the toxic side effects of sanguinarine, its cyanide derivative (1a) was first designed and synthesized in our previous research. In this study, we confirmed that 1a presents lower toxicity than sanguinarine but shows comparable anti-leukemia activity. Further biological studies using RNA-seq, lentiviral transfection, Western blotting, and flow cytometry analysis first revealed that both compounds 1 and 1a inhibited the proliferation and induced the apoptosis of leukemic cells by regulating the transcription of c-MET and then suppressing downstream pathways, including the MAPK, PI3K/AKT and JAK/STAT pathways. Collectively, the data indicate that 1a, as a potential anti-leukemia lead compound regulating c-MET transcription, exhibits better safety than 1 while maintaining cytostatic activity through the same mechanism as 1.
关键词	leukemia sanguinarine c-MET MAPK PI3K/mTOR STAT3 MET
学科领域	Biochemistry & Molecular Biology ; Chemistry
DOI	10.3390/ijms24098113
WOS记录号	WOS:000987326400001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75015
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Xu,Xinglian,Deng,Lulu,Tang,Yaling,et al. Cytostatic Activity of Sanguinarine and a Cyanide Derivative in Human Erythroleukemia Cells Is Mediated by Suppression of c-MET/MAPK Signaling[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2023,24(9):8113.
APA	Xu,Xinglian.,Deng,Lulu.,Tang,Yaling.,Li,Jiang.,Zhong,Ting.,...&Mu,Shuzhen.(2023).Cytostatic Activity of Sanguinarine and a Cyanide Derivative in Human Erythroleukemia Cells Is Mediated by Suppression of c-MET/MAPK Signaling.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,24(9),8113.
MLA	Xu,Xinglian,et al."Cytostatic Activity of Sanguinarine and a Cyanide Derivative in Human Erythroleukemia Cells Is Mediated by Suppression of c-MET/MAPK Signaling".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 24.9(2023):8113.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
10.3390_ijms24098113（5829KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	浏览下载