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Discovery of novel modulators targeting human TRPC5: Docking-based virtual screening, molecular dynamics simulation and binding af fi nity predication 期刊论文
JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 2021, 卷号: 102, 页码: 107795
作者:  Liu,Bin;  Zhang,Wei;  Guo,Sheng;  Zuo,Zhili
浏览  |  Adobe PDF(4277Kb)  |  收藏  |  浏览/下载：80/10  |  提交时间：2022/04/02
hTRPC5  Homology modeling  Molecular docking  Molecular dynamics simulation  Virtual screening  INHIBITOR  CHANNELS  GROMACS  POTENT  AMBER  IDENTIFICATION  CONSTRAINTS  INTEGRATION  AMYGDALA  
Identification of Novel TRPC5 Inhibitors by Pharmacophore-Based and Structure-Based Approaches 期刊论文
COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2020
作者:  Li, Shuxiang;  Zhang, Shuqun;  Chen, Dingyuan;  Jiang, Xuan;  Liu, Bin;  Zhang, Hongbin;  Rachakunta, Munikishore;  Zuo, Zhili
浏览  |  Adobe PDF(4261Kb)  |  收藏  |  浏览/下载：133/33  |  提交时间：2021/01/05
Bioassay-guided isolation of anti-inflammatory diterpenoids with highly oxygenated substituents from kidney tea (Clerodendranthus spicatus) 期刊论文
JOURNAL OF FOOD BIOCHEMISTRY, 2020
作者:  Chen, Wei-Di;  Zhao, Yun-Li;  Dai, Zhi;  Zhou, Zhong-Shun;  Zhu, Pei-Feng;  Liu, Ya-Ping;  Zhao, Li-Xing;  Luo, Xiao-Dong
浏览  |  Adobe PDF(1146Kb)  |  收藏  |  浏览/下载：129/42  |  提交时间：2021/01/05
Petchiether A attenuates obstructive nephropathy by suppressing TGF-ss/Smad3 and NF-kappa B signalling 期刊论文
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2019, 卷号: 23, 期号: 8, 页码: 5576-5587
作者:  You, Yong-Ke;  Luo, Qi;  Wu, Wei-Feng;  Zhang, Jiao-Jiao;  Zhu, Hong-Jian;  Lao, Lixing;  Lan, Hui Y.;  Chen, Hai-Yong;  Cheng, Yong-Xian
浏览  |  Adobe PDF(3491Kb)  |  收藏  |  浏览/下载：157/48  |  提交时间：2019/10/14
fibrosis  NF-kappa B  obstructive nephropathy  petchiether A  TGF-ss/Smad3  
Pyrazolopyrimidines as Potent Stimulators for Transient Receptor Potential Canonical 3/6/7 Channels 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 11, 页码: 4680-4692
作者:  Qu, Chunrong;  Ding, Mingmin;  Zhu, Yingmin;  Lu, Yungang;  Du, Juan;  Miller, Melissa;  Tian, Jinbin;  Zhu, Jinmei;  Xui, Jian;  Wen, Meng;  Er-Bu, Aga;  Wan, Jule;  Xiao, Yuling;  Wu, Meng;  McManus, Owen B.;  Li, Min;  Wu, Jilin;  Luo, Huai-Rong;  Cao, Zhengyu;  Shen, Bing;  Wang, Hongbo;  Zhu, Michael X.;  Hong, Xuechuan
浏览  |  Adobe PDF(1969Kb)  |  收藏  |  浏览/下载：207/77  |  提交时间：2017/08/29
Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels 期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2015, 卷号: 172, 期号: 14, 页码: 3495-3509
作者:  Zhu, Yingmin;  Lu, Yungang;  Qu, Chunrong;  Miller, Melissa;  Tian, Jinbin;  Thakur, Dhananjay P.;  Zhu, Jinmei;  Deng, Zixin;  Hu, Xianming;  Wu, Meng;  McManus, Owen B.;  Li, Min;  Hong, Xuechuan;  Zhu, Michael X.;  Luo, Huai-Rong
浏览  |  Adobe PDF(2298Kb)  |  收藏  |  浏览/下载：191/47  |  提交时间：2015/12/15
细胞累积脂肪模型建立及腺花素调控脂肪细胞分化研究 学位论文
, 北京: 中国科学院大学, 2014
作者:  田维锋
Adobe PDF(1672Kb)  |  收藏  |  浏览/下载：102/8  |  提交时间：2016/05/31
药物筛选模型  腺花素  3t3-l1  脂肪细胞分化  
Renoprotective mechanisms of pirfenidone in hypertension-induced renal injury: through anti-fibrotic and anti-oxidative stress pathways 期刊论文
BIOMEDICAL RESEARCH-TOKYO, 2013, 卷号: 34, 期号: 6, 页码: 309-319
作者:  Ji, Xu;  Naito, Yukiko;  Weng, Huachun;  Ma, Xiao;  Endo, Kosuke;  Kito, Naoko;  Yanagawa, Nariaki;  Yu, Yang;  Li, Jie;  Iwai, Naoharu
浏览  |  Adobe PDF(8370Kb)  |  收藏  |  浏览/下载：217/17  |  提交时间：2015/05/14
Sesquiterpenoids with New Carbon Skeletons from the Resin of Toxicodendron vernicifluum as New Types of Extracellular Matrix Inhibitors 期刊论文
ORGANIC LETTERS, 2013, 卷号: 15, 期号: 14, 页码: 3602-3605
作者:  He, Jiang-Bo;  Luo, Jie;  Zhang, Li;  Yan, Yong-Min;  Cheng, Yong-Xian
浏览  |  Adobe PDF(274Kb)  |  收藏  |  浏览/下载：410/83  |  提交时间：2013/10/16
Diabetic-nephropathy  Metabolism  
Acortatarin A inhibits high glucose-induced extracellular matrix production in mesangial cells 期刊论文
CHINESE MEDICAL JOURNAL, 2013, 卷号: 126, 期号: 7, 页码: 1230-1235
作者:  Zhao Zhi-fang;  Zhou Li-li;  Chen Xia;  Cheng Yong-xian;  Hou Fan-fan;  Nie Jing
浏览  |  Adobe PDF(165Kb)  |  收藏  |  浏览/下载：416/95  |  提交时间：2013/07/24
Acortatarin a  High Glucose  Mesangial Cells  Extracellular Matrix