Sesquiterpenoids with New Carbon Skeletons from the Resin of Toxicodendron vernicifluum as New Types of Extracellular Matrix Inhibitors

	Sesquiterpenoids with New Carbon Skeletons from the Resin of Toxicodendron vernicifluum as New Types of Extracellular Matrix Inhibitors
	He, Jiang-Bo 1,2; Luo, Jie 1; Zhang, Li 3; Yan, Yong-Min 1,2; Cheng, Yong-Xian 1
通讯作者	Cheng, YX (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China. ; yxcheng@mail.kib.ac.cn
	2013-07-19
发表期刊	ORGANIC LETTERS
ISSN	1523-7060
卷号	15 期号:14 页码:3602-3605
摘要	Toxicodenanes A-C (1-3), representing sesquiterpenoids with three new carbon skeletons, were isolated from the dried resin of Toxicodendron vernicifluum. Their structures were identified by spectroscopic data and X-ray diffraction crystallography. Their plausible biosynthetic route was proposed via the isolated intermediate (4). Compounds 2 and 3 could significantly inhibit overproduction of fibronectin, collagen IV, and IL-6 in high-glucose-induced mesangial cells in a dose- and time-dependent manner, showing their potential in diabetic nephropathy.
关键词	Diabetic-nephropathy Metabolism
学科领域	Chemistry, Organic
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000322210600030
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/16737
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
推荐引用方式 GB/T 7714	He, Jiang-Bo,Luo, Jie,Zhang, Li,et al. Sesquiterpenoids with New Carbon Skeletons from the Resin of Toxicodendron vernicifluum as New Types of Extracellular Matrix Inhibitors[J]. ORGANIC LETTERS,2013,15(14):3602-3605.
APA	He, Jiang-Bo,Luo, Jie,Zhang, Li,Yan, Yong-Min,&Cheng, Yong-Xian.(2013).Sesquiterpenoids with New Carbon Skeletons from the Resin of Toxicodendron vernicifluum as New Types of Extracellular Matrix Inhibitors.ORGANIC LETTERS,15(14),3602-3605.
MLA	He, Jiang-Bo,et al."Sesquiterpenoids with New Carbon Skeletons from the Resin of Toxicodendron vernicifluum as New Types of Extracellular Matrix Inhibitors".ORGANIC LETTERS 15.14(2013):3602-3605.

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