Sesquiterpenoids with New Carbon Skeletons from the Resin of Toxicodendron vernicifluum as New Types of Extracellular Matrix Inhibitors
He, Jiang-Bo1,2; Luo, Jie1; Zhang, Li3; Yan, Yong-Min1,2; Cheng, Yong-Xian1
2013-07-19
发表期刊ORGANIC LETTERS
ISSN1523-7060
卷号15期号:14页码:3602-3605
摘要Toxicodenanes A-C (1-3), representing sesquiterpenoids with three new carbon skeletons, were isolated from the dried resin of Toxicodendron vernicifluum. Their structures were identified by spectroscopic data and X-ray diffraction crystallography. Their plausible biosynthetic route was proposed via the isolated intermediate (4). Compounds 2 and 3 could significantly inhibit overproduction of fibronectin, collagen IV, and IL-6 in high-glucose-induced mesangial cells in a dose- and time-dependent manner, showing their potential in diabetic nephropathy.
关键词Diabetic-nephropathy Metabolism
资助信息NSFC-Joint Foundation of Yunnan Province [U1202222]; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences [P2010-ZZ09, P2013-ZZ03]
收录类别SCI ; IC
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/16737
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
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He, Jiang-Bo,Luo, Jie,Zhang, Li,et al. Sesquiterpenoids with New Carbon Skeletons from the Resin of Toxicodendron vernicifluum as New Types of Extracellular Matrix Inhibitors[J]. ORGANIC LETTERS,2013,15(14):3602-3605.
APA He, Jiang-Bo,Luo, Jie,Zhang, Li,Yan, Yong-Min,&Cheng, Yong-Xian.(2013).Sesquiterpenoids with New Carbon Skeletons from the Resin of Toxicodendron vernicifluum as New Types of Extracellular Matrix Inhibitors.ORGANIC LETTERS,15(14),3602-3605.
MLA He, Jiang-Bo,et al."Sesquiterpenoids with New Carbon Skeletons from the Resin of Toxicodendron vernicifluum as New Types of Extracellular Matrix Inhibitors".ORGANIC LETTERS 15.14(2013):3602-3605.
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