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题名: Sesquiterpenoids with New Carbon Skeletons from the Resin of Toxicodendron vernicifluum as New Types of Extracellular Matrix Inhibitors
作者: He, Jiang-Bo1, 2; Luo, Jie1; Zhang, Li3; Yan, Yong-Min1, 2; null(程永现)1
刊名: ORGANIC LETTERS
关键词: DIABETIC-NEPHROPATHY ; METABOLISM
英文摘要: Toxicodenanes A-C (1-3), representing sesquiterpenoids with three new carbon skeletons, were isolated from the dried resin of Toxicodendron vernicifluum. Their structures were identified by spectroscopic data and X-ray diffraction crystallography. Their plausible biosynthetic route was proposed via the isolated intermediate (4). Compounds 2 and 3 could significantly inhibit overproduction of fibronectin, collagen IV, and IL-6 in high-glucose-induced mesangial cells in a dose- and time-dependent manner, showing their potential in diabetic nephropathy.
出版日期: 2013-07-19
卷号: 15, 期号:14, 页码:3602-3605
语种: 英语
收录类别: SCI ; IC
学科分类: Chemistry, Organic
ISSN号: 1523-7060
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/16737
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China

Recommended Citation:
He, Jiang-Bo; Luo, Jie; Zhang, Li; Yan, Yong-Min; Cheng, Yong-Xian.Sesquiterpenoids with New Carbon Skeletons from the Resin of Toxicodendron vernicifluum as New Types of Extracellular Matrix Inhibitors,ORGANIC LETTERS,2013,15(14):3602-3605
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文件名: He-2013-Sesquiterpenoids wit.pdf
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