Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels
Zhu, Yingmin1; Lu, Yungang1,2; Qu, Chunrong3; Miller, Melissa4,5; Tian, Jinbin1; Thakur, Dhananjay P.1; Zhu, Jinmei3; Deng, Zixin3; Hu, Xianming2; Wu, Meng4,5; McManus, Owen B.4,5; Li, Min4,5; Hong, Xuechuan3; Zhu, Michael X.1; Luo, Huai-Rong6
2015-07-01
Source PublicationBRITISH JOURNAL OF PHARMACOLOGY
Volume172Issue:14Pages:3495-3509
AbstractBackground and PurposeTransient receptor potential canonical (TRPC) channels play important roles in a broad array of physiological functions and are involved in various diseases. However, due to a lack of potent subtype-specific inhibitors the exact roles of TRPC channels in physiological and pathophysiological conditions have not been elucidated.
DOI10.1111/bph.13140
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000356976300004
Citation statistics
Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/24937
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Univ Texas Hlth Sci Ctr Houston, Dept Integrat Biol & Pharmacol, Houston, TX 77030 USA
2.Guangzhou Med Univ, Affiliated Hosp 3, Guangzhou, Guangdong, Peoples R China
3.Wuhan Univ, State Key Lab Virol, Key Lab Combinatorial Biosynth & Drug Discovery, Minist Educ,Sch Pharmaceut Sci, Wuhan 430072, Hubei, Peoples R China
4.Johns Hopkins Univ, Sch Med, Dept Neurosci, High Throughput Biol Ctr, Baltimore, MD 21205 USA
5.Johns Hopkins Univ, Johns Hopkins Ion Channel Ctr, Baltimore, MD USA
6.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Zhu, Yingmin,Lu, Yungang,Qu, Chunrong,et al. Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels[J]. BRITISH JOURNAL OF PHARMACOLOGY,2015,172(14):3495-3509.
APA Zhu, Yingmin.,Lu, Yungang.,Qu, Chunrong.,Miller, Melissa.,Tian, Jinbin.,...&Luo, Huai-Rong.(2015).Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels.BRITISH JOURNAL OF PHARMACOLOGY,172(14),3495-3509.
MLA Zhu, Yingmin,et al."Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels".BRITISH JOURNAL OF PHARMACOLOGY 172.14(2015):3495-3509.
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