Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels
Zhu, Yingmin1; Lu, Yungang1,2; Qu, Chunrong3; Miller, Melissa4,5; Tian, Jinbin1; Thakur, Dhananjay P.1; Zhu, Jinmei3; Deng, Zixin3; Hu, Xianming2; Wu, Meng4,5; McManus, Owen B.4,5; Li, Min4,5; Hong, Xuechuan3; Zhu, Michael X.1; Luo, Huai-Rong6
2015-07-01
发表期刊BRITISH JOURNAL OF PHARMACOLOGY
卷号172期号:14页码:3495-3509
摘要Background and PurposeTransient receptor potential canonical (TRPC) channels play important roles in a broad array of physiological functions and are involved in various diseases. However, due to a lack of potent subtype-specific inhibitors the exact roles of TRPC channels in physiological and pathophysiological conditions have not been elucidated.
DOI10.1111/bph.13140
收录类别SCI
语种英语
WOS记录号WOS:000356976300004
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/24937
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Univ Texas Hlth Sci Ctr Houston, Dept Integrat Biol & Pharmacol, Houston, TX 77030 USA
2.Guangzhou Med Univ, Affiliated Hosp 3, Guangzhou, Guangdong, Peoples R China
3.Wuhan Univ, State Key Lab Virol, Key Lab Combinatorial Biosynth & Drug Discovery, Minist Educ,Sch Pharmaceut Sci, Wuhan 430072, Hubei, Peoples R China
4.Johns Hopkins Univ, Sch Med, Dept Neurosci, High Throughput Biol Ctr, Baltimore, MD 21205 USA
5.Johns Hopkins Univ, Johns Hopkins Ion Channel Ctr, Baltimore, MD USA
6.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China
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GB/T 7714
Zhu, Yingmin,Lu, Yungang,Qu, Chunrong,et al. Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels[J]. BRITISH JOURNAL OF PHARMACOLOGY,2015,172(14):3495-3509.
APA Zhu, Yingmin.,Lu, Yungang.,Qu, Chunrong.,Miller, Melissa.,Tian, Jinbin.,...&Luo, Huai-Rong.(2015).Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels.BRITISH JOURNAL OF PHARMACOLOGY,172(14),3495-3509.
MLA Zhu, Yingmin,et al."Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels".BRITISH JOURNAL OF PHARMACOLOGY 172.14(2015):3495-3509.
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