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USP47 maintains the stemness of colorectal cancer cells and is inhibited by parthenolide 期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2021, 卷号: 562, 页码: 21-28
作者:  Zhang,Shaohua;  Ju,Xiaoman;  Yang,Qihong;  Zhu,Yiying;  Fan,Dongmei;  Su,Guifeng;  Kong,Lingmei;  Li,Yan
浏览  |  Adobe PDF(2615Kb)  |  收藏  |  浏览/下载:154/37  |  提交时间:2022/04/02
USP47  Cancer stem cell  Colorectal cancer  Parthenolide  Deubiquitinase  SESQUITERPENE LACTONE PARTHENOLIDE  DEUBIQUITINASES  STABILIZATION  LEUKEMIA  
Uncovering the role of a positive selection site of wax ester synthase/diacylglycerol acyltransferase in two closely related Stipa species in wax ester synthesis under drought stress 期刊论文
JOURNAL OF EXPERIMENTAL BOTANY, 2020
作者:  Yang, Yunqiang;  Zhou, Zhili;  Li, Yan;  Lv, Yanqiu;  Yang, Danni;  Yang, Shihai;  Wu, Jianshuang;  Li, Xiong;  Gu, Zhijia;  Sun, Xudong;  Yang, Yongping
浏览  |  Adobe PDF(3551Kb)  |  收藏  |  浏览/下载:201/54  |  提交时间:2021/01/05
Parthenolide inhibits ubiquitin-specific peptidase 7 (USP7), Wnt signaling, and colorectal cancer cell growth 期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2020
作者:  Li, Xue;  Kong, Lingmei;  Yang, Qihong;  Duan, Aizhu;  Ju, Xiaoman;  Cai, Bicheng;  Chen, Lin;  An, Tao;  Li, Yan
浏览  |  Adobe PDF(2381Kb)  |  收藏  |  浏览/下载:146/57  |  提交时间:2021/01/05
Parvifoline AA Promotes Susceptibility of Hepatocarcinoma to Natural Killer Cell-Mediated Cytolysis by Targeting Peroxiredoxin 期刊论文
CELL CHEMICAL BIOLOGY, 2019, 卷号: 26, 期号: 8, 页码: 1122-+
作者:  Zhu, Huifang;  Wang, Bin;  Kong, Lingmei;  An, Tao;  Li, Gentao;  Zhou, Hongyu;  Gong, Liang;  Zhao, Zhangxun;  Gong, Yaxiao;  Sun, Handong;  Puno, Pematenzin;  Li, Yan
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B591, a novel specific pan-PI3K inhibitor, preferentially targets cancer stem cells 期刊论文
ONCOGENE, 2019, 卷号: 38, 期号: 18, 页码: 3371-3386
作者:  Zhou, Hongyu;  Yu, Chunlei;  Kong, Lingmei;  Xu, Xiaoliang;  Yan, Juming;  Li, Yingchao;  An, Tao;  Gong, Liang;  Gong, Yaxiao;  Zhu, Huifang;  Zhang, Hongbin;  Yang, Xiaodong;  Li, Yan
浏览  |  Adobe PDF(5225Kb)  |  收藏  |  浏览/下载:254/31  |  提交时间:2019/06/24
Physalis peruviana-Derived 4 beta-Hydroxywithanolide E, a Novel Antagonist of Wnt Signaling, Inhibits Colorectal Cancer In Vitro and In Vivo 期刊论文
MOLECULES, 2019, 卷号: 24, 期号: 6, 页码: 13
作者:  Ye, Zhen-Nan;  Yuan, Feng;  Liu, Jie-Qing;  Peng, Xing-Rong;  An, Tao;  Li, Xue;  Kong, Ling-Mei;  Qiu, Ming-Hua;  Li, Yan
浏览  |  Adobe PDF(3189Kb)  |  收藏  |  浏览/下载:174/35  |  提交时间:2019/07/29
4 beta HWE  Wnt signaling pathway  beta-catenin  colorectal cancer  
Pestalotiopsin C, stereochemistry of a new caryophyllene from a fungus of Trichoderma sp and its tautomerization characteristics in solution 期刊论文
TETRAHEDRON, 2015, 卷号: 71, 期号: 21, 页码: 3491-3494
作者:  Yu, He;  Li, Wen-Xin;  Wang, Jing-Chen;  Yang, Qin;  Wang, Hui-Jun;  Zhang, Can-Can;  Ding, Shuang-Shuang;  Li, Yan;  Zhu, Hua-Jie;  Zhu,HJ (reprint author),Hebei Univ,Coll Pharm,Chinese Ctr Chiral,Key Lab Med Chem & Mol Diagnost,Minist Educ,Baoding 071002,Hebei,Peoples R China.;  hjzhu@mail.kib.ac.cn
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Pestalotiopsin c  Trichoderma Sp  Optical Rotation  Ecd  Transition State  
Cinchona Alkaloids from Cinchona succirubra and Cinchona ledgeriana 期刊论文
PLANTA MEDICA, 2014, 卷号: 80, 期号: 2-3, 页码: 223-230
作者:  Cheng, Gui-Guang;  Cai, Xiang-Hai;  Zhang, Bao-Hong;  Li, Yan;  Gu, Ji;  Bao, Mei-Fen;  Liu, Ya-Ping;  Luo, Xiao-Dong
Adobe PDF(169Kb)  |  收藏  |  浏览/下载:409/117  |  提交时间:2014/04/09
Multidrug-resistance  Combined Nmr  Leaves  Quinidine  Quinine  Root  Derivatives  Cultures  Moens  Leaf  
Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者:  Zeng, Guang-Zhi;  Fan, Jun-Ting;  Xu, Jun-Ju;  Li, Yan;  Tan, Ning-Hua
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One Of The Major compOnents Isolated From The Traditional  2-methyl-1  Chinese Medicine Rubia Yunnanensis  3  Exhibited Inhibitory Activity On The proliferatiOn Of Several  6-trihydroxy-9  HumAn CAncer Cell Lines. The Results From An Annexin V-fitc (fluoresein-5-isothiocyAnate) Apoptosis Assay  10-anthraquinone (Mta)  And Dna Content Analysis Showed That Mta Exerted Cytotoxicity Via Apoptosis Induction And G2/m Cell Cycle  Arrest In Human Cervical carcInoma Hela Cells. Further  Mta Was Found To Induce apopTosis Of Hela Cells  Through The MITochondria-mediated Pathway. It Caused The Translocation Of Bax To The mITochondria And  Release Of Cytochrome c Into The Cytosol  Which Caused The Cleavage Of Caspase And Poly(Adp-ribose)  Polymerase And Finally Triggered The Apoptosis. furThermore  The P53/p21/cdc2-cyclin B1 Signaling Was  Found Related To The G2/m Arrest Caused By Mta. The Over-expression Of P21 And Down-expression Of  Cyclin B1 Caused By Mta Inactivated The cdc2-Cyclin B1 Complex Of G2/m Checkpoint And Finally Caused  The G2/m Arrest In Hela Cells. ThIs Study Demonstrated That Mta Is a Potential Anti-cancer Component Of  R. Yunnanensis  a Folk Anti-cancer Herb Used In Yunnan  China.  
The functional roles of lipid rafts in T-Cell activation, immune diseases and HIV infection and prevention 期刊论文
CELLULAR & MOLECULAR IMMUNOLOGY, 2008, 卷号: 5, 期号: 1, 页码: 1-7
作者:  Luo, Cheng;  Wang, Kou;  Liu, Dequan;  Li, Yan;  Zhao, Qinshi
Adobe PDF(909Kb)  |  收藏  |  浏览/下载:329/117  |  提交时间:2011/11/24
Lipid Raft  Liquid Ordered Phase  Liquid Crystal Phase  Cholesterol  Virus Assembly