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B591, a novel specific pan-PI3K inhibitor, preferentially targets cancer stem cells 期刊论文
ONCOGENE, 2019, 卷号: 38, 期号: 18, 页码: 3371-3386
Authors:  Zhou, Hongyu;  Yu, Chunlei;  Kong, Lingmei;  Xu, Xiaoliang;  Yan, Juming;  Li, Yingchao;  An, Tao;  Gong, Liang;  Gong, Yaxiao;  Zhu, Huifang;  Zhang, Hongbin;  Yang, Xiaodong;  Li, Yan
Favorite  |  View/Download:36/0  |  Submit date:2019/06/24
Ciclopirox induces autophagy through reactive oxygen species-mediated activation of JNK signaling pathway 期刊论文
ONCOTARGET, 2014, 卷号: 5, 期号: 20, 页码: 10140-10150
Authors:  Zhou, Hongyu;  Shen, Tao;  Shang, Chaowei;  Luo, Yan;  Liu, Lei;  Yan, Juming;  Li, Yan;  Huang, Shile
View  |  Adobe PDF(2703Kb)  |  Favorite  |  View/Download:89/16  |  Submit date:2015/06/17
Ciclopirox  Autophagy  Rhabdomyosarcoma  Reactive Oxygen Species  Jnk  
Mangiferin and its aglycone, norathyriol, improve glucose metabolism by activation of AMP-activated protein kinase 期刊论文
PHARMACEUTICAL BIOLOGY, 2014, 卷号: 52, 期号: 1, 页码: 68-73
Authors:  Wang, Fang;  Yan, Juming;  Niu, Yanfen;  Li, Yan;  Lin, Hua;  Liu, Xu;  Liu, Jikai;  Li, Ling
View  |  Adobe PDF(383Kb)  |  Favorite  |  View/Download:164/23  |  Submit date:2014/04/09
Active Metabolite  Ampk  Insulin Resistance  L6 Muscle Cells  Norathyriol  
Scapiformolactones A-I: Germacrane sesquiterpenoids with an unusual Delta(3)-15,6-lactone moiety from Salvia scapiformis 期刊论文
PHYTOCHEMISTRY, 2013, 卷号: 96, 页码: 378-388
Authors:  Lai, Yongji;  Xue, Yongbo;  Zhang, Mengke;  Zhang, Jinwen;  Tang, Wei;  Liu, Junjun;  Lei, Liang;  Yan, Juming;  Luo, Zengwei;  Zuo, Jianping;  Li, Yan;  Yao, Guangmin;  Zhang, Yonghui
View  |  Adobe PDF(1398Kb)  |  Favorite  |  View/Download:119/22  |  Submit date:2015/05/12
Salvia Scapiformis  Lamiaceae  Germacrane Sesquiterpene  Conformation  Chemical Transformation  Quantum Mechanical Calculation  Cytotoxicity Immunomodulatory Activity  
Identification of two novel inhibitors of mTOR signaling pathway based on high content screening 期刊论文
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2013, 卷号: 72, 期号: 4, 页码: 799-808
Authors:  Yan, Juming;  Zhou, Hongyu;  Kong, Lingmei;  Zhang, Jing;  Zhao, Qinshi;  Li, Yan
Adobe PDF(1971Kb)  |  Favorite  |  View/Download:546/66  |  Submit date:2013/11/12
Mtor Signaling  Inhibitor  High Content Screening  Cancer  Apoptosis  
Trichothecin Induces Cell Death in NF-kappa B Constitutively Activated Human Cancer Cells via Inhibition of IKK beta Phosphorylation 期刊论文
PLOS ONE, 2013, 卷号: 8, 期号: 8, 页码: e71333
Authors:  Su, Jia;  Zhao, Peiji;  Kong, Lingmei;  Li, Xingyao;  Yan, Juming;  Zeng, Ying;  Li, Yan
Adobe PDF(1124Kb)  |  Favorite  |  View/Download:212/27  |  Submit date:2013/11/12
Colitis-associated Cancer  Multiple-myeloma Cells  P65 Phosphorylation  Endophytic Fungus  Kinase-activity  Tumor-growth  In-vitro  Pathway  Apoptosis  Inflammation  
mTOR信号通路抑制剂筛选及抗肿瘤活性和机制研究 学位论文
, 北京: 中国科学院大学, 2013
Authors:  闫居明
Adobe PDF(2112Kb)  |  Favorite  |  View/Download:130/9  |  Submit date:2016/05/31
肿瘤  Mtor信号通路  天然产物  活性筛选  机制研究  
5-取代二氢苯并呋喃—咪唑盐类化合物及其制备方法 专利
专利类型: 发明, 专利号: CN201210465477.8, 申请日期: 2012-11-19, 公开日期: 2013-11-27
Inventors:  张洪彬;  羊晓东;  李艳;  徐晓亮;  李莹超;  闫居明;  周宏宇
Adobe PDF(1414Kb)  |  Favorite  |  View/Download:115/5  |  Submit date:2016/12/19
ent-Kaurane Diterpenoids from Isodon eriocalyx var. laxiflora 期刊论文
CHINESE JOURNAL OF CHEMISTRY, 2012, 卷号: 30, 期号: 6, 页码: 1226-1230
Authors:  Wang Weiguang;  Wu Haiyan;  Du Xue;  Yan Juming;  Li Yan;  Pu Jianxin;  Sun Handong
Adobe PDF(535Kb)  |  Favorite  |  View/Download:112/31  |  Submit date:2014/04/02
Ent-kaurane Diterpenoid  Isodon  Structure Elucidation  Cytotoxicity