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B591, a novel specific pan-PI3K inhibitor, preferentially targets cancer stem cells 期刊论文
ONCOGENE, 2019, 卷号: 38, 期号: 18, 页码: 3371-3386
Authors:  Zhou, Hongyu;  Yu, Chunlei;  Kong, Lingmei;  Xu, Xiaoliang;  Yan, Juming;  Li, Yingchao;  An, Tao;  Gong, Liang;  Gong, Yaxiao;  Zhu, Huifang;  Zhang, Hongbin;  Yang, Xiaodong;  Li, Yan
Favorite  |  View/Download:36/0  |  Submit date:2019/06/24
四氢异喹啉-2-甲基苯并咪唑盐类化合物及其制备方法和应用 专利
申请日期: 2018-07-18, 公开日期: 2018-11-06
Inventors:  羊晓东;  张洪彬;  李艳;  刘洋;  段胜祖;  李良;  周宏宇
Favorite  |  View/Download:4/0  |  Submit date:2019/08/14
一种17β-咪唑烷基溴盐-去氢表雄烷衍生物及其制备方法和应用 专利
申请日期: 2018-07-18, 公开日期: 2018-12-21
Inventors:  羊晓东;  张洪彬;  李艳;  邓国刚;  周备;  李良;  周宏宇
Favorite  |  View/Download:0/0  |  Submit date:2019/08/14
USP7 inhibitor P5091 inhibits Wnt signaling and colorectal tumor growth 期刊论文
BIOCHEMICAL PHARMACOLOGY, 2017, 卷号: 131, 期号: 1, 页码: 29-39
Authors:  An, Tao;  Gong, Yaxiao;  Li, Xue;  Kong, Lingmei;  Ma, Pengcheng;  Gong, Liang;  Zhu, Huifang;  Yu, Chunlei;  Liu, Jianmei;  Zhou, Hongyu;  Mao, Bingyu;  Li, Yan
View  |  Adobe PDF(3138Kb)  |  Favorite  |  View/Download:623/95  |  Submit date:2017/04/06
Usp7 Inhibitor  Wnt Signaling  Colorectal Cancer  
Ciclopirox olamine inhibits mTORC1 signaling by activation of AMPK 期刊论文
BIOCHEMICAL PHARMACOLOGY, 2016, 卷号: 116, 页码: 39-50
Authors:  Zhou, Hongyu;  Shang, Chaowei;  Wang, Min;  Shen, Tao;  Kong, Lingmei;  Yu, Chunlei;  Ye, Zhennan;  Luo, Yan;  Liu, Lei;  Li, Yan;  Huang, Shile
View  |  Adobe PDF(3794Kb)  |  Favorite  |  View/Download:71/6  |  Submit date:2017/01/05
Ciclopirox  Mtor  Ampk  Tsc2  Raptor  
N-Hydroxyphthalimide exhibits antitumor activity by suppressing mTOR signaling pathway in BT-20 and LoVo cells 期刊论文
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2016, 卷号: 35
Authors:  Wang, Min;  Zhou, Ankun;  An, Tao;  Kong, Lingmei;  Yu, Chunlei;  Liu, Jianmei;  Xia, Chengfeng;  Zhou, Hongyu;  Li, Yan
View  |  Adobe PDF(1734Kb)  |  Favorite  |  View/Download:77/6  |  Submit date:2016/06/27
N-hydroxyphthalimide  Mtor  Inhibitor  Cancer  Mitochondrial Apoptosis  
N-羟基邻苯二甲酰亚胺类化合物在制备抗肿瘤药物中的应用 专利
专利类型: 发明, 专利号: CN201510882376.4, 申请日期: 2015-12-04, 公开日期: 2016-03-30
Inventors:  周宏宇;  李艳;  夏成峰;  孔令梅;  周安坤;  王敏
Adobe PDF(822Kb)  |  Favorite  |  View/Download:278/20  |  Submit date:2016/12/19
Ciclopirox induces autophagy through reactive oxygen species-mediated activation of JNK signaling pathway 期刊论文
ONCOTARGET, 2014, 卷号: 5, 期号: 20, 页码: 10140-10150
Authors:  Zhou, Hongyu;  Shen, Tao;  Shang, Chaowei;  Luo, Yan;  Liu, Lei;  Yan, Juming;  Li, Yan;  Huang, Shile
View  |  Adobe PDF(2703Kb)  |  Favorite  |  View/Download:89/16  |  Submit date:2015/06/17
Ciclopirox  Autophagy  Rhabdomyosarcoma  Reactive Oxygen Species  Jnk  
Identification of two novel inhibitors of mTOR signaling pathway based on high content screening 期刊论文
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2013, 卷号: 72, 期号: 4, 页码: 799-808
Authors:  Yan, Juming;  Zhou, Hongyu;  Kong, Lingmei;  Zhang, Jing;  Zhao, Qinshi;  Li, Yan
Adobe PDF(1971Kb)  |  Favorite  |  View/Download:546/66  |  Submit date:2013/11/12
Mtor Signaling  Inhibitor  High Content Screening  Cancer  Apoptosis  
双(α-呋喃甲酸)氧钒作为抗癌药物的新用途 专利
专利类型: 发明, 专利号: CN201310394759.8, 申请日期: 2013-09-03, 公开日期: 2014-02-26
Inventors:  刘伟平;  李艳;  李玲;  谌喜珠;  周宏宇;  高丽辉;  张静;  姜婧
Adobe PDF(503Kb)  |  Favorite  |  View/Download:137/6  |  Submit date:2016/12/19