| Parvifoline AA Promotes Susceptibility of Hepatocarcinoma to Natural Killer Cell-Mediated Cytolysis by Targeting Peroxiredoxin | |
Zhu, Huifang1,2; Wang, Bin1,2 ; Kong, Lingmei1; An, Tao1; Li, Gentao1,4; Zhou, Hongyu1; Gong, Liang1,2; Zhao, Zhangxun1,2; Gong, Yaxiao1; Sun, Handong1; Puno, Pematenzin1; Li, Yan1,3
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| Corresponding Author | Puno, Pematenzin(punopematenzin@mail.kib.ac.cn) ; Li, Yan(liyanb@mail.kib.ac.cn) |
| 2019-08-15 | |
| Source Publication | CELL CHEMICAL BIOLOGY
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| ISSN | 2451-9448 |
| Volume | 26Issue:8Pages:1122-+ |
| Abstract | Natural killer (NK) cells play a crucial role in the surveillance of malignant cells. The engagement of NK group 2 member D (NKG2D) receptor with its ligands on target cells represents a promising therapeutic strategy against cancers. Here, we report that parvifoline AA (PAA), a natural ent-kaurane diterpenoid, markedly stimulates the expression of NKG2D ligands on hepatocellular carcinoma (HCC) cells, considerably enhancing their recognition and lysis by NK cells. We determined that PAA covalently binds to the conserved cysteine site of peroxiredoxins I/II (Prxs-I/II) and inhibits their catalytic activity, subsequently activating the ROS/ERK axis and the immunogenicity of HCC toward NK cells. Robust tumor growth inhibition by PAA dependent on NK cell activation was detected in vivo. Our data suggest Prxs-I/II as a promising cancer immune therapeutic target and provide a compelling rationale for further development of the inhibitor PAA as a sensitizer agent for NK cell-mediated HCC immunotherapy. |
| DOI | 10.1016/j.chembiol.2019.04.003 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000481604100009 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/68365 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Corresponding Author | Puno, Pematenzin; Li, Yan |
| Affiliation | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China 4.Tianjin Univ, Sch Pharmaceut Sci & Technol, Tianjin 300072, Peoples R China |
| Recommended Citation GB/T 7714 | Zhu, Huifang,Wang, Bin,Kong, Lingmei,et al. Parvifoline AA Promotes Susceptibility of Hepatocarcinoma to Natural Killer Cell-Mediated Cytolysis by Targeting Peroxiredoxin[J]. CELL CHEMICAL BIOLOGY,2019,26(8):1122-+. |
| APA | Zhu, Huifang.,Wang, Bin.,Kong, Lingmei.,An, Tao.,Li, Gentao.,...&Li, Yan.(2019).Parvifoline AA Promotes Susceptibility of Hepatocarcinoma to Natural Killer Cell-Mediated Cytolysis by Targeting Peroxiredoxin.CELL CHEMICAL BIOLOGY,26(8),1122-+. |
| MLA | Zhu, Huifang,et al."Parvifoline AA Promotes Susceptibility of Hepatocarcinoma to Natural Killer Cell-Mediated Cytolysis by Targeting Peroxiredoxin".CELL CHEMICAL BIOLOGY 26.8(2019):1122-+. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| zhu2019.pdf（4600KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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