Parvifoline AA Promotes Susceptibility of Hepatocarcinoma to Natural Killer Cell-Mediated Cytolysis by Targeting Peroxiredoxin

doi:10.1016/j.chembiol.2019.04.003

	Parvifoline AA Promotes Susceptibility of Hepatocarcinoma to Natural Killer Cell-Mediated Cytolysis by Targeting Peroxiredoxin
	Zhu, Huifang 1,2; Wang, Bin1,2 ; Kong, Lingmei 1; An, Tao1 ; Li, Gentao 1,4; Zhou, Hongyu 1; Gong, Liang 1,2; Zhao, Zhangxun 1,2; Gong, Yaxiao 1; Sun, Handong1 ; Puno, Pematenzin 1; Li, Yan1,3
通讯作者	Puno, Pematenzin(punopematenzin@mail.kib.ac.cn) ; Li, Yan(liyanb@mail.kib.ac.cn)
	2019-08-15
发表期刊	CELL CHEMICAL BIOLOGY
ISSN	2451-9448
卷号	26 期号:8 页码:1122-+
摘要	Natural killer (NK) cells play a crucial role in the surveillance of malignant cells. The engagement of NK group 2 member D (NKG2D) receptor with its ligands on target cells represents a promising therapeutic strategy against cancers. Here, we report that parvifoline AA (PAA), a natural ent-kaurane diterpenoid, markedly stimulates the expression of NKG2D ligands on hepatocellular carcinoma (HCC) cells, considerably enhancing their recognition and lysis by NK cells. We determined that PAA covalently binds to the conserved cysteine site of peroxiredoxins I/II (Prxs-I/II) and inhibits their catalytic activity, subsequently activating the ROS/ERK axis and the immunogenicity of HCC toward NK cells. Robust tumor growth inhibition by PAA dependent on NK cell activation was detected in vivo. Our data suggest Prxs-I/II as a promising cancer immune therapeutic target and provide a compelling rationale for further development of the inhibitor PAA as a sensitizer agent for NK cell-mediated HCC immunotherapy.
DOI	10.1016/j.chembiol.2019.04.003
收录类别	SCI
语种	英语
WOS记录号	WOS:000481604100009
引用统计	被引频次：13[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/68365
专题	植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Puno, Pematenzin; Li, Yan
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China 4.Tianjin Univ, Sch Pharmaceut Sci & Technol, Tianjin 300072, Peoples R China
推荐引用方式 GB/T 7714	Zhu, Huifang,Wang, Bin,Kong, Lingmei,et al. Parvifoline AA Promotes Susceptibility of Hepatocarcinoma to Natural Killer Cell-Mediated Cytolysis by Targeting Peroxiredoxin[J]. CELL CHEMICAL BIOLOGY,2019,26(8):1122-+.
APA	Zhu, Huifang.,Wang, Bin.,Kong, Lingmei.,An, Tao.,Li, Gentao.,...&Li, Yan.(2019).Parvifoline AA Promotes Susceptibility of Hepatocarcinoma to Natural Killer Cell-Mediated Cytolysis by Targeting Peroxiredoxin.CELL CHEMICAL BIOLOGY,26(8),1122-+.
MLA	Zhu, Huifang,et al."Parvifoline AA Promotes Susceptibility of Hepatocarcinoma to Natural Killer Cell-Mediated Cytolysis by Targeting Peroxiredoxin".CELL CHEMICAL BIOLOGY 26.8(2019):1122-+.

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