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Discovery of isopenicin A, a meroterpenoid as a novel inhibitor of tubulin polymerization 期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2020, 卷号: 525, 期号: 2, 页码: 303-307
Authors:  Chen, Lin;  Fan, Dong-Mei;  Tang, Jian-Wei;  An, Tao;  Li, Xue;  Kong, Ling-Mei;  Puno, Pema-Tenzin;  Li, Yan
Favorite  |  View/Download:19/0  |  Submit date:2020/06/08
Isopenicin A  Meroterpenoid  Microtubule  Cancer  Endophytic fungus  
Synthesis and biological evaluation of chepraecoxin A derivatives as alpha-glucosidase inhibitors 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 8, 页码: 5
Authors:  Yang, Xiao-Tong;  Geng, Chang-An;  Li, Tian-Ze;  Deng, Zhen-Tao;  Chen, Ji-Jun
Favorite  |  View/Download:20/0  |  Submit date:2020/05/27
Chepraecoxin A  alpha-Glucosidase inhibitory activity  Enzyme kinetics  Non-competitive inhibitor  
Parthenolide inhibits ubiquitin-specific peptidase 7 (USP7), Wnt signaling, and colorectal cancer cell growth 期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2020, 卷号: 295, 期号: 11, 页码: 3576-3589
Authors:  Li, Xue;  Kong, Lingmei;  Yang, Qihong;  Duan, Aizhu;  Ju, Xiaoman;  Cai, Bicheng;  Chen, Lin;  An, Tao;  Li, Yan
Favorite  |  View/Download:12/0  |  Submit date:2020/06/08
small molecule  deubiquitylation (deubiquitination)  Wnt signaling  pharmacology  enzyme inhibitor  ?-catenin  parthenolide  ubiquitination  USP7  Wnt signaling  ubiquitin-specific peptidase 7  colorectal cancer  proteasome system  protein homeostasis  deubiquitinating activity  
ent-Labdane and ent-kaurane diterpenoids from Chelonopsis odontochila with alpha-glucosidase inhibitory activity 期刊论文
BIOORGANIC CHEMISTRY, 2020, 卷号: 95, 页码: 10
Authors:  Deng, Zhen-Tao;  Chen, Ji-Jun;  Geng, Chang-An
Favorite  |  View/Download:35/0  |  Submit date:2020/04/07
Cheodontoins A-K  Ent-Labdane diterpenoids  Ent-Kaurane diterpenoids  alpha-Glucosidase inhibitory activity  Chelonopsis odontochila  Enzyme kinetics  Docking study  
Star-PAP regulates tumor protein D52 through modulating miR-449a/34a in breast cancer 期刊论文
BIOLOGY OPEN, 2019, 卷号: 8, 期号: 11, 页码: 9
Authors:  Duan, Aizhu;  Kong, Lingmei;  An, Tao;  Zhou, Hongyu;  Yu, Chunlei;  Li, Yan
View  |  Adobe PDF(2302Kb)  |  Favorite  |  View/Download:29/4  |  Submit date:2020/03/02
Star-PAP  TPD52  miR-449a  miR-34a  Breast cancer  
Parvifoline AA Promotes Susceptibility of Hepatocarcinoma to Natural Killer Cell-Mediated Cytolysis by Targeting Peroxiredoxin 期刊论文
CELL CHEMICAL BIOLOGY, 2019, 卷号: 26, 期号: 8, 页码: 1122-+
Authors:  Zhu, Huifang;  Wang, Bin;  Kong, Lingmei;  An, Tao;  Li, Gentao;  Zhou, Hongyu;  Gong, Liang;  Zhao, Zhangxun;  Gong, Yaxiao;  Sun, Handong;  Puno, Pematenzin;  Li, Yan
View  |  Adobe PDF(4600Kb)  |  Favorite  |  View/Download:49/4  |  Submit date:2019/10/14
Polybenzyls from Gastrodia elata, their agonistic effects on melatonin receptors and structure-activity relationships 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 卷号: 27, 期号: 15, 页码: 3299-3306
Authors:  Chen, Si-Yue;  Geng, Chang-An;  Ma, Yun-Bao;  Huang, Xiao-Yan;  Yang, Xiao-Tong;  Su, Li-Hua;  He, Xiao-Feng;  Li, Tian-Ze;  Deng, Zhen-Tao;  Gao, Zhen;  Zhang, Xue-Mei;  Chen, Ji-Jun
View  |  Adobe PDF(1837Kb)  |  Favorite  |  View/Download:57/3  |  Submit date:2019/09/10
Gastrodia elata  Polybenzyls  Melatonin receptors  Structure-activity relationships  Docking study  
B591, a novel specific pan-PI3K inhibitor, preferentially targets cancer stem cells 期刊论文
ONCOGENE, 2019, 卷号: 38, 期号: 18, 页码: 3371-3386
Authors:  Zhou, Hongyu;  Yu, Chunlei;  Kong, Lingmei;  Xu, Xiaoliang;  Yan, Juming;  Li, Yingchao;  An, Tao;  Gong, Liang;  Gong, Yaxiao;  Zhu, Huifang;  Zhang, Hongbin;  Yang, Xiaodong;  Li, Yan
View  |  Adobe PDF(5225Kb)  |  Favorite  |  View/Download:84/5  |  Submit date:2019/06/24
Physalis peruviana-Derived 4 beta-Hydroxywithanolide E, a Novel Antagonist of Wnt Signaling, Inhibits Colorectal Cancer In Vitro and In Vivo 期刊论文
MOLECULES, 2019, 卷号: 24, 期号: 6, 页码: 13
Authors:  Ye, Zhen-Nan;  Yuan, Feng;  Liu, Jie-Qing;  Peng, Xing-Rong;  An, Tao;  Li, Xue;  Kong, Ling-Mei;  Qiu, Ming-Hua;  Li, Yan
View  |  Adobe PDF(3189Kb)  |  Favorite  |  View/Download:26/4  |  Submit date:2019/07/29
4 beta HWE  Wnt signaling pathway  beta-catenin  colorectal cancer  
Chepraecoxins A-G, ent-Kaurane Diterpenoids with alpha-Glucosidase Inhibitory Activities from Chelonopsis praecox 期刊论文
FITOTERAPIA, 2019, 卷号: 132, 页码: 60-67
Authors:  Deng, Zhen-Tao;  Geng, Chang-An;  Yang, Tong-Hua;  Xiang, Chun-Lei;  Chen, Ji-Jun
View  |  Adobe PDF(1349Kb)  |  Favorite  |  View/Download:66/7  |  Submit date:2019/03/18
Chelonopsis praecox  chepraecoxins A-G  ent-kaurane diterpenoids  alpha-glucosidase