| N-Hydroxyphthalimide exhibits antitumor activity by suppressing mTOR signaling pathway in BT-20 and LoVo cells | |
Wang, Min1,2; Zhou, Ankun1; An, Tao1,2 ; Kong, Lingmei1; Yu, Chunlei1,2; Liu, Jianmei1; Xia, Chengfeng1; Zhou, Hongyu1; Li, Yan1
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| 2016-03-03 | |
| 发表期刊 | JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
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| 卷号 | 35 |
| 摘要 | Background: N-Hydroxyphthalimide (NHPI), an important chemical raw material, was found to have potent and selective anti-proliferative effect on human breast carcinoma BT-20 cells, human colon adenocarcinoma LoVo and HT-29 cells during our screening for anticancer compounds. The purpose of this study is to assess the antitumor efficacy of NHPI in vitro and in vivo and to explore the underlying antitumor mechanism. |
| 关键词 | N-hydroxyphthalimide Mtor Inhibitor Cancer Mitochondrial Apoptosis |
| DOI | 10.1186/s13046-016-0315-1 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000371383700001 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/26003 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Min,Zhou, Ankun,An, Tao,et al. N-Hydroxyphthalimide exhibits antitumor activity by suppressing mTOR signaling pathway in BT-20 and LoVo cells[J]. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH,2016,35. |
| APA | Wang, Min.,Zhou, Ankun.,An, Tao.,Kong, Lingmei.,Yu, Chunlei.,...&Li, Yan.(2016).N-Hydroxyphthalimide exhibits antitumor activity by suppressing mTOR signaling pathway in BT-20 and LoVo cells.JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH,35. |
| MLA | Wang, Min,et al."N-Hydroxyphthalimide exhibits antitumor activity by suppressing mTOR signaling pathway in BT-20 and LoVo cells".JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 35(2016). |
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| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| 10.1186@s13046-016-0（1734KB） | 开放获取 | CC BY-NC-SA | 浏览 下载 | |||
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