Ciclopirox olamine sensitizes leukemia cells to natural killer cell-mediated cytolysis by upregulating NKG2DLs via the Akt signaling pathway

doi:10.1016/j.bbrc.2023.03.062

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	Ciclopirox olamine sensitizes leukemia cells to natural killer cell-mediated cytolysis by upregulating NKG2DLs via the Akt signaling pathway
	Zhu,Yiying; Zhao,Zhangxun; Xue,Minggao; Wang,Dan; Su,Guifeng; Ju,Xiaoman; Yang,Qihong; Zhang,Shaohua; Fan,Dongmei; Zhu,Huifang; Yu,Min; Li,Yan; Kong,Lingmei; Zhou,Hongyu
	2023
发表期刊	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
ISSN	1090-2104
卷号	659 页码:10-19
摘要	The activating receptor natural killer group 2D (NKG2D) expressed by Natural killer (NK) cells functions as a master-switch in governing the awakening status of NK cells. The NKG2D-mediated cytotoxicity has been declared to be related with the expression levels of NKG2D ligands (NKG2DLs) expressed on tumor cells. Therefore, selective induction of NKG2DLs could be a reliable approach to enhance the ef-ficacy of NK cell-mediated immunotherapy. Our existing study demonstrated that Ciclopirox Olamine (CPX), an off-patent antifungal agent, effectively elevated the expression of NKG2DLs on leukemia cells and sensitized leukemia cells to NK-cell mediated cytolysis. Induction of ROS production and AKT phosphorylation by CPX is essential for the up-regulation of NKG2DLs expressions. Inhibition of AKT by using AKT inhibitor MK2206 decreased both NKG2DLs expressions and NK cell cytotoxicity. These data indicated that increased sensitivity of CPX-treated leukemia cells to NK cell cytolysis was attributed to higher NKG2DLs expressions, resulting from activated AKT signaling pathway. Our findings support the ongoing development of CPX as an anti-tumor agent and suggest its promising immunotherapeutic value in the medication of leukemia.(c) 2023 Elsevier Inc. All rights reserved.
关键词	Ciclopirox olamine Natural killer cells NKG2D ligands Immunotherapy LIGANDS RECEPTOR GROWTH
学科领域	Biochemistry & Molecular Biology ; Biophysics
DOI	10.1016/j.bbrc.2023.03.062
收录类别	SCI
WOS记录号	WOS:000977422400001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75482
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Zhu,Yiying,Zhao,Zhangxun,Xue,Minggao,et al. Ciclopirox olamine sensitizes leukemia cells to natural killer cell-mediated cytolysis by upregulating NKG2DLs via the Akt signaling pathway[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2023,659:10-19.
APA	Zhu,Yiying.,Zhao,Zhangxun.,Xue,Minggao.,Wang,Dan.,Su,Guifeng.,...&Zhou,Hongyu.(2023).Ciclopirox olamine sensitizes leukemia cells to natural killer cell-mediated cytolysis by upregulating NKG2DLs via the Akt signaling pathway.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,659,10-19.
MLA	Zhu,Yiying,et al."Ciclopirox olamine sensitizes leukemia cells to natural killer cell-mediated cytolysis by upregulating NKG2DLs via the Akt signaling pathway".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 659(2023):10-19.

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