Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells
Zeng, Guang-Zhi; Fan, Jun-Ting; Xu, Jun-Ju; Li, Yan; Tan, Ning-Hua
2013-04-01
Source PublicationPHARMAZIE
Volume68Issue:4Pages:293-299
KeywordOne Of The Major compOnents Isolated From The Traditional 2-methyl-1 Chinese Medicine Rubia Yunnanensis 3 Exhibited Inhibitory Activity On The proliferatiOn Of Several 6-trihydroxy-9 HumAn CAncer Cell Lines. The Results From An Annexin V-fitc (fluoresein-5-isothiocyAnate) Apoptosis Assay 10-anthraquinone (Mta) And Dna Content Analysis Showed That Mta Exerted Cytotoxicity Via Apoptosis Induction And G2/m Cell Cycle Arrest In Human Cervical carcInoma Hela Cells. Further Mta Was Found To Induce apopTosis Of Hela Cells Through The MITochondria-mediated Pathway. It Caused The Translocation Of Bax To The mITochondria And Release Of Cytochrome c Into The Cytosol Which Caused The Cleavage Of Caspase And Poly(Adp-ribose) Polymerase And Finally Triggered The Apoptosis. furThermore The P53/p21/cdc2-cyclin B1 Signaling Was Found Related To The G2/m Arrest Caused By Mta. The Over-expression Of P21 And Down-expression Of Cyclin B1 Caused By Mta Inactivated The cdc2-Cyclin B1 Complex Of G2/m Checkpoint And Finally Caused The G2/m Arrest In Hela Cells. ThIs Study Demonstrated That Mta Is a Potential Anti-cancer Component Of R. Yunnanensis a Folk Anti-cancer Herb Used In Yunnan China.
Indexed BySCI
Language英语
WOS IDWOS:000334259900011
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/19252
Collection植物化学与西部植物资源持续利用国家重点实验室
AffiliationChinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
Recommended Citation
GB/T 7714
Zeng, Guang-Zhi,Fan, Jun-Ting,Xu, Jun-Ju,et al. Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells[J]. PHARMAZIE,2013,68(4):293-299.
APA Zeng, Guang-Zhi,Fan, Jun-Ting,Xu, Jun-Ju,Li, Yan,&Tan, Ning-Hua.(2013).Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells.PHARMAZIE,68(4),293-299.
MLA Zeng, Guang-Zhi,et al."Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells".PHARMAZIE 68.4(2013):293-299.
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