中国科学院昆明植物研究所机构知识库
Advanced  
KIB OpenIR  > 植物化学与西部植物资源持续利用国家重点实验室  > 期刊论文
题名: Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells
作者: Zeng, Guang-Zhi1; Fan, Jun-Ting1; Xu, Jun-Ju1; null(李艳)1; Tan, Ning-Hua1
刊名: PHARMAZIE
关键词: 2-Methyl-1,3,6-trihydroxy-9,10-anthraquinone (MTA) ; one of the major components isolated from the traditional ; Chinese medicine Rubia yunnanensis ; exhibited inhibitory activity on the proliferation of several ; human cancer cell lines. The results from an annexin V-FITC (fluoresein-5-isothiocyanate) apoptosis assay ; and DNA content analysis showed that MTA exerted cytotoxicity via apoptosis induction and G2/M cell cycle ; arrest in human cervical carcinoma HeLa cells. Further ; MTA was found to induce apoptosis of HeLa cells ; through the mitochondria-mediated pathway. It caused the translocation of Bax to the mitochondria and ; release of cytochrome c into the cytosol ; which caused the cleavage of caspase and poly(ADP-ribose) ; polymerase and finally triggered the apoptosis. Furthermore ; the p53/p21/Cdc2-cyclin B1 signaling was ; found related to the G2/M arrest caused by MTA. The over-expression of p21 and down-expression of ; cyclin B1 caused by MTA inactivated the Cdc2-cyclin B1 complex of G2/M checkpoint and finally caused ; the G2/M arrest in HeLa cells. This study demonstrated that MTA is a potential anti-cancer component of ; R. yunnanensis ; a folk anti-cancer herb used in Yunnan ; China.
出版日期: 2013-04-01
卷号: 68, 期号:4, 页码:293-299
语种: 英语
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/19252
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
s11.pdf(6299KB)期刊论文作者接受稿开放获取View 联系获取全文

作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China

Recommended Citation:
Zeng, Guang-Zhi,Fan, Jun-Ting,Xu, Jun-Ju,et al. Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells[J]. PHARMAZIE,2013,68(4):293-299.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zeng, Guang-Zhi]'s Articles
[Fan, Jun-Ting]'s Articles
[Xu, Jun-Ju]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zeng, Guang-Zhi]‘s Articles
[Fan, Jun-Ting]‘s Articles
[Xu, Jun-Ju]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: s11.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  中国科学院昆明植物研究所 - Feedback
Powered by CSpace