Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells
Zeng, Guang-Zhi; Fan, Jun-Ting; Xu, Jun-Ju; Li, Yan; Tan, Ning-Hua
2013-04-01
发表期刊PHARMAZIE
卷号68期号:4页码:293-299
关键词One Of The Major compOnents Isolated From The Traditional 2-methyl-1 Chinese Medicine Rubia Yunnanensis 3 Exhibited Inhibitory Activity On The proliferatiOn Of Several 6-trihydroxy-9 HumAn CAncer Cell Lines. The Results From An Annexin V-fitc (fluoresein-5-isothiocyAnate) Apoptosis Assay 10-anthraquinone (Mta) And Dna Content Analysis Showed That Mta Exerted Cytotoxicity Via Apoptosis Induction And G2/m Cell Cycle Arrest In Human Cervical carcInoma Hela Cells. Further Mta Was Found To Induce apopTosis Of Hela Cells Through The MITochondria-mediated Pathway. It Caused The Translocation Of Bax To The mITochondria And Release Of Cytochrome c Into The Cytosol Which Caused The Cleavage Of Caspase And Poly(Adp-ribose) Polymerase And Finally Triggered The Apoptosis. furThermore The P53/p21/cdc2-cyclin B1 Signaling Was Found Related To The G2/m Arrest Caused By Mta. The Over-expression Of P21 And Down-expression Of Cyclin B1 Caused By Mta Inactivated The cdc2-Cyclin B1 Complex Of G2/m Checkpoint And Finally Caused The G2/m Arrest In Hela Cells. ThIs Study Demonstrated That Mta Is a Potential Anti-cancer Component Of R. Yunnanensis a Folk Anti-cancer Herb Used In Yunnan China.
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy ; Chemistry
WOS类目Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
WOS记录号WOS:000334259900011
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/19252
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
推荐引用方式
GB/T 7714
Zeng, Guang-Zhi,Fan, Jun-Ting,Xu, Jun-Ju,et al. Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells[J]. PHARMAZIE,2013,68(4):293-299.
APA Zeng, Guang-Zhi,Fan, Jun-Ting,Xu, Jun-Ju,Li, Yan,&Tan, Ning-Hua.(2013).Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells.PHARMAZIE,68(4),293-299.
MLA Zeng, Guang-Zhi,et al."Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells".PHARMAZIE 68.4(2013):293-299.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
s11.pdf(6299KB)期刊论文作者接受稿开放获取CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zeng, Guang-Zhi]的文章
[Fan, Jun-Ting]的文章
[Xu, Jun-Ju]的文章
百度学术
百度学术中相似的文章
[Zeng, Guang-Zhi]的文章
[Fan, Jun-Ting]的文章
[Xu, Jun-Ju]的文章
必应学术
必应学术中相似的文章
[Zeng, Guang-Zhi]的文章
[Fan, Jun-Ting]的文章
[Xu, Jun-Ju]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。