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Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
Authors:  Zeng, Guang-Zhi;  Fan, Jun-Ting;  Xu, Jun-Ju;  Li, Yan;  Tan, Ning-Hua
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One Of The Major compOnents Isolated From The Traditional  2-methyl-1  Chinese Medicine Rubia Yunnanensis  3  Exhibited Inhibitory Activity On The proliferatiOn Of Several  6-trihydroxy-9  HumAn CAncer Cell Lines. The Results From An Annexin V-fitc (fluoresein-5-isothiocyAnate) Apoptosis Assay  10-anthraquinone (Mta)  And Dna Content Analysis Showed That Mta Exerted Cytotoxicity Via Apoptosis Induction And G2/m Cell Cycle  Arrest In Human Cervical carcInoma Hela Cells. Further  Mta Was Found To Induce apopTosis Of Hela Cells  Through The MITochondria-mediated Pathway. It Caused The Translocation Of Bax To The mITochondria And  Release Of Cytochrome c Into The Cytosol  Which Caused The Cleavage Of Caspase And Poly(Adp-ribose)  Polymerase And Finally Triggered The Apoptosis. furThermore  The P53/p21/cdc2-cyclin B1 Signaling Was  Found Related To The G2/m Arrest Caused By Mta. The Over-expression Of P21 And Down-expression Of  Cyclin B1 Caused By Mta Inactivated The cdc2-Cyclin B1 Complex Of G2/m Checkpoint And Finally Caused  The G2/m Arrest In Hela Cells. ThIs Study Demonstrated That Mta Is a Potential Anti-cancer Component Of  R. Yunnanensis  a Folk Anti-cancer Herb Used In Yunnan  China.  
Constituents of Carapa guianensis Aubl. (Meliaceae) 期刊论文
PHARMAZIE, 2004, 卷号: 59, 期号: 6, 页码: 488-490
Authors:  Qi, SH;  Wu, DG;  Zhang, S;  Luo, XD
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Leiocyclocin C and D, two cyclopeptides from Goniothalamus leiocarpus 期刊论文
PHARMAZIE, 2003, 卷号: 58, 期号: 10, 页码: 756-758
Authors:  Q. Mu;  R. W. Teng;  C. M. Li;  D. Z. Wang;  Y. Wu;  H. D. Sun;  C. Q. Hu
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Activities of prenylphenol derivatives from fruitbodies of Albatrellus spp. on the human and rat vanilloid receptor 1 (VR1) and characterisation of the novel natural product confluentin 期刊论文
ARCHIV DER PHARMAZIE, 2003, 卷号: 336, 期号: 2, 页码: 119-126
Authors:  Hellwig, V;  Nopper, R;  Mauler, F;  Freitag, J;  Liu, JK;  Ding, ZH;  Stadler, M
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Basidiomycetes  Pain  Scutigeral  Neogrifolin  Grifolin  Albaconol  
Chemcial constituents from the marine sponge Iotrochoto birotulata 期刊论文
Pharmazie, 2003, 卷号: 58, 期号: 9, 页码: 680-681
Authors:  Liya Li1
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Procyanidins from the herb of Hypericum perforatum 期刊论文
Pharmazie, 2001, 卷号: 56, 期号: 6, 页码: 509-511
Authors:  O.Ploss;  F.Petereit;  A.Nahrstedt
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Coumarins from Hypericum keniense(Guttiferae) 期刊论文
Pharmazie, 1999, 卷号: 54, 期号: 3, 页码: 235-236
Authors:  C.A.ang'edu;  J.SCHMIDT;  A.Porzel;  P.GITU;  J.O.MIDiYYO;  G.ADAM
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Orthoforin:The main degradation product of hyperforin from Hypericum perforatum 期刊论文
Pharmazie, 1999, 卷号: 54, 期号: 1, 页码: 76-77
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Oxidative 期刊论文
Pharmazie, 1992, 卷号: 47, 页码: 582
Authors:  R.U.B.Ebana;  B.E.Madunagu;  E.D.Ekpe;  I.N.Otung
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