Activities of prenylphenol derivatives from fruitbodies of Albatrellus spp. on the human and rat vanilloid receptor 1 (VR1) and characterisation of the novel natural product confluentin

	Activities of prenylphenol derivatives from fruitbodies of Albatrellus spp. on the human and rat vanilloid receptor 1 (VR1) and characterisation of the novel natural product confluentin
	Hellwig, V ; Nopper, R ; Mauler, F ; Freitag, J ; Liu, JK ; Ding, ZH ; Stadler, M
	2003-04-01
发表期刊	ARCHIV DER PHARMAZIE
卷号	336 期号:2 页码:119-126
摘要	Several prenylphenols from basidiocarps of European and Chinese Albatrellus spp., namely grifolin (1), neogrifolin (2), confluentin (3), scutigeral (4), and albaconol (5) were investigated concerning their activities in test models for vanilloid receptor modulation. The isolation of these compounds from A. confluens and structure elucidation of the novel natural product confluentin (3) are described. The effects of scutigeral and neogrifolin on vanilloid receptors were studied by means of electrophysiological methodology on rat dorsal root ganglion neurons as well as on recombinant cell lines expressing the rat VR1 receptor. Concurrently, the effects of compounds 1-5 on a reporter cell line expressing the human vanilloid receptor VR1 were measured. In contrast to previous studies reported in the literature, the results of these investigations suggest that fungal prenylphenols act as weak antagonists (activity in the muM range), rather than exhibiting agonistic activities.
关键词	Basidiomycetes Pain Scutigeral Neogrifolin Grifolin Albaconol
收录类别	SCI
语种	英语
WOS记录号	WOS:000182734400005
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/23980
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.PH R EU ET Nat Prod, Pharma Res Ctr Wuppertal, Bayer Hlth Care, D-42096 Wuppertal, Germany 2.CNS Res, Pharma Res Ctr Wuppertal, Bayer Hlth Care, Wuppertal, Germany 3.Chinese Acad Sci, Kunming Inst Bot, Kunming, Peoples R China
推荐引用方式 GB/T 7714	Hellwig, V,Nopper, R,Mauler, F,et al. Activities of prenylphenol derivatives from fruitbodies of Albatrellus spp. on the human and rat vanilloid receptor 1 (VR1) and characterisation of the novel natural product confluentin[J]. ARCHIV DER PHARMAZIE,2003,336(2):119-126.
APA	Hellwig, V.,Nopper, R.,Mauler, F.,Freitag, J.,Liu, JK.,...&Stadler, M.(2003).Activities of prenylphenol derivatives from fruitbodies of Albatrellus spp. on the human and rat vanilloid receptor 1 (VR1) and characterisation of the novel natural product confluentin.ARCHIV DER PHARMAZIE,336(2),119-126.
MLA	Hellwig, V,et al."Activities of prenylphenol derivatives from fruitbodies of Albatrellus spp. on the human and rat vanilloid receptor 1 (VR1) and characterisation of the novel natural product confluentin".ARCHIV DER PHARMAZIE 336.2(2003):119-126.

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