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瘤果黑种草子和两种紫珠属药用植物化学成分及生物活性研究 学位论文
博士, 2018
Authors:  高俊博
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绛县产冬凌草药材的评价 学位论文
: 中国科学院大学, 2017
Authors:  张源渊
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Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
Authors:  Zeng, Guang-Zhi;  Fan, Jun-Ting;  Xu, Jun-Ju;  Li, Yan;  Tan, Ning-Hua
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One Of The Major compOnents Isolated From The Traditional  2-methyl-1  Chinese Medicine Rubia Yunnanensis  3  Exhibited Inhibitory Activity On The proliferatiOn Of Several  6-trihydroxy-9  HumAn CAncer Cell Lines. The Results From An Annexin V-fitc (fluoresein-5-isothiocyAnate) Apoptosis Assay  10-anthraquinone (Mta)  And Dna Content Analysis Showed That Mta Exerted Cytotoxicity Via Apoptosis Induction And G2/m Cell Cycle  Arrest In Human Cervical carcInoma Hela Cells. Further  Mta Was Found To Induce apopTosis Of Hela Cells  Through The MITochondria-mediated Pathway. It Caused The Translocation Of Bax To The mITochondria And  Release Of Cytochrome c Into The Cytosol  Which Caused The Cleavage Of Caspase And Poly(Adp-ribose)  Polymerase And Finally Triggered The Apoptosis. furThermore  The P53/p21/cdc2-cyclin B1 Signaling Was  Found Related To The G2/m Arrest Caused By Mta. The Over-expression Of P21 And Down-expression Of  Cyclin B1 Caused By Mta Inactivated The cdc2-Cyclin B1 Complex Of G2/m Checkpoint And Finally Caused  The G2/m Arrest In Hela Cells. ThIs Study Demonstrated That Mta Is a Potential Anti-cancer Component Of  R. Yunnanensis  a Folk Anti-cancer Herb Used In Yunnan  China.  
Draft Genome of the Filarial Nematode Parasite Brugia malayi 期刊论文
Science, 2007, 卷号: 317, 页码: 1756-1760
Authors:  Elodie Ghedin;  Shiliang Wang;  David Spiro;  Elisabet Caler;  Qi Zhao;  Jonathan Crabtree;  Jonathan E. Allen;  Arthur L. Delcher;  David B. Guiliano;  Diego Miranda-Saavedra;  Samuel V. Angiuoli;  Todd Creasy;  Paolo Amedeo;  Brian Haas;  Najib M. El-Sayed;  Jennifer R. Wortman;  Tamara Feldblyum;  Luke Tallon;  Michael Schatz;  Martin Shumway;  Hean Koo;  Steven L. Salzberg;  Seth Schobel;  Mihaela Pertea;  Mihai Pop;  Owen White;  Geoffrey J. Barton;  Clotilde K. S. Carlow;  Michael J. Crawford;  Jennifer Daub;  Matthew W. Dimmic;  Chris F. Estes;  Jeremy M. Foster;  Mehul Ganatra;  William F. Gregory;  Nicholas M. Johnson;  Jinming Jin;  Richard Komuniecki;  Ian Korf;  Sanjay Kumar;  Sandra Laney;  Ben-Wen Li;  Wen Li;  Tim H. Lindblom;  Sara Lustigman;  Dong Ma;  Claude Maina;  David Martin;  James P. McCarter;  Larry McReynolds;  Makedonka Mitreva;  Thomas B. Nutman;  John Parkinson;  José M. Peregrín-Alvarez;  Catherine Poole;  Qinghu Ren;  Lori Saunders;  Ann E. Sluder;  Katherine Smith;  Mario Stanke;  Thomas R. Unnasch;  Jenna Ware;  Aguan D. Wei;  Gary Weil;  Deryck J. Williams;  Yinhua Zhang;  Steven A. Williams;  Claire Fraser-Liggett;  Barton Slatko;  Mark L. Blaxter;  Alan L. Scott
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Biochemistry of Signal Transduction and Regulation 3rd ed 专著
WILEY-VCH Verlag:WILEY-VCH Verlag, 2003
Gerhard Krauss
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, 2003
H. Lodish
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Gene Regulation and Metabolism Postgenomic Computational Approaches 专著
London:MIT Press, 2002
Julio Collado-Vides; Ralf Hofestadt
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Principles of Genetics 7th Ed. 专著
, 2001
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