Pestalotiopsin C, stereochemistry of a new caryophyllene from a fungus of Trichoderma sp and its tautomerization characteristics in solution
Yu, He1; Li, Wen-Xin1; Wang, Jing-Chen1; Yang, Qin1; Wang, Hui-Jun1; Zhang, Can-Can1; Ding, Shuang-Shuang1; Li, Yan2; Zhu, Hua-Jie1; Zhu,HJ (reprint author),Hebei Univ,Coll Pharm,Chinese Ctr Chiral,Key Lab Med Chem & Mol Diagnost,Minist Educ,Baoding 071002,Hebei,Peoples R China.; hjzhu@mail.kib.ac.cn
2015-05-27
Source PublicationTETRAHEDRON
Volume71Issue:21Pages:3491-3494
AbstractA new pestalotiopsin C (1) with three known compounds (2-4) are obtained from the fermentation broth of fungus of Trichoderma KK19L1 sp. Pestalotiopsin C (I) has two atropisomers with mole ratio of 1.2/1 in chloroform at room temperature. Its structure was well established by 1D and 2D NMR, and further confirmed by X-ray diffraction. Its absolute configuration (AC) was determined by comparing its experimental electronic circular dichroism (ECD) and optical rotation (OR) value with the calculated ECD and OR data using quantum methods. The bioactivity of compound 1 was tested against five cell-lines HL-60, SMMC-7721, A-549, MCF-7, SW480, respectively. (C) 2015 Elsevier Ltd. All rights reserved.
KeywordPestalotiopsin c Trichoderma Sp Optical Rotation Ecd Transition State
Subject AreaChemistry, Organic
DOI10.1016/j.tet.2015.03.063
Indexed BySCI
Language英语
WOS IDWOS:000355031000041
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/21330
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorZhu,HJ (reprint author),Hebei Univ,Coll Pharm,Chinese Ctr Chiral,Key Lab Med Chem & Mol Diagnost,Minist Educ,Baoding 071002,Hebei,Peoples R China.; hjzhu@mail.kib.ac.cn
Affiliation1.Hebei Univ, Coll Pharm, Chinese Ctr Chiral, Key Lab Med Chem & Mol Diagnost,Minist Educ, Baoding 071002, Hebei, Peoples R China
2.Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Yu, He,Li, Wen-Xin,Wang, Jing-Chen,et al. Pestalotiopsin C, stereochemistry of a new caryophyllene from a fungus of Trichoderma sp and its tautomerization characteristics in solution[J]. TETRAHEDRON,2015,71(21):3491-3494.
APA Yu, He.,Li, Wen-Xin.,Wang, Jing-Chen.,Yang, Qin.,Wang, Hui-Jun.,...&hjzhu@mail.kib.ac.cn.(2015).Pestalotiopsin C, stereochemistry of a new caryophyllene from a fungus of Trichoderma sp and its tautomerization characteristics in solution.TETRAHEDRON,71(21),3491-3494.
MLA Yu, He,et al."Pestalotiopsin C, stereochemistry of a new caryophyllene from a fungus of Trichoderma sp and its tautomerization characteristics in solution".TETRAHEDRON 71.21(2015):3491-3494.
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