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中国科学院昆明植物研究所知识管理系统
Knowledge Management System of Kunming Institute of Botany,CAS
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Novel nucleocapsid protein-targeting phenanthridine inhibitors of SARS-CoV-2
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 227, 页码: 113966
Authors:
Wang,Yi-Ting
;
Long,Xin-Yan
;
Ding,Xiao
;
Fan,Shi-Rui
;
Cai,Jie-Yun
;
Yang,Bi-Juan
;
Zhang,Xin-Fang
;
Luo,Rong-hua
;
Yang,Lian
;
Ruan,Ting
;
Ren,Juan
;
Jing,Chen-Xu
;
Zheng,Yong-Tang
;
Hao,Xiao-Jiang
;
Chen,Duo-Zhi
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View/Download:11/0
  |  
Submit date:2022/04/02
Phenanthridine
Nucleocapsid protein
SARS-CoV-2
N-terminal domain
N-TERMINAL DOMAIN
CORONAVIRUS
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 11, 页码: 7404-7421
Authors:
Zhou,Zongyuan
;
Li,Yiming
;
Ma,Xiaofang
;
Cao,Biyun
;
Peng,Ting
;
Sheng,Yuwen
;
Peng,Huipan
;
Li,Runze
;
Cao,Yu
;
Xi,Ruiying
;
Li,Fu
;
Wang,Mengru
;
Sun,Handong
;
Zhang,Guolin
;
Zhang,Hongbin
;
Hu,Kaifeng
;
Xiao,Weilie
;
Wang,Fei
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  |  
Submit date:2022/04/02
GOMISIN-A
DIBENZOCYCLOOCTADIENE LIGNANS
SCHISANDRA-CHINENSIS
MASS-SPECTROMETRY
MIRNA EXPRESSION
DOWN-REGULATION
NONCODING RNA
MICRORNA
LIVER
DICER
Structures/cytotoxicity/selectivity relationship of natural steroidal saponins against GSCs and primary mechanism of tribulosaponin A
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 210, 页码: 113068
Authors:
Dai,Zhi
;
Liu,Hui
;
Wang,Bei
;
Yang,Dong
;
Zhu,Yan-Yan
;
Yan,Huan
;
Zhu,Pei-Feng
;
Liu,Ya-Ping
;
Chen,Hui-Cheng
;
Zhao,Yun-li
;
Zhao,Li-Xing
;
Zhao,Xu-Dong
;
Liu,Hai-Yang
;
Luo,Xiao-Dong
Favorite
  |  
View/Download:3/0
  |  
Submit date:2022/04/02
Steroidal saponins
Structure-activity relationship
Tribulosaponin A
Glioma stem cells
ROS
SMALL MOLECULES
CARDIAC-ARREST
STEM-CELL
IDENTIFICATION
THERAPY
BRAIN
OPPORTUNITIES
GLIOMA
TUMORS
NOX2
Congenetic Hybrids Derived from Dearomatized Isoprenylated Acylphloroglucinol with Opposite Effects on Ca(v)3.1 Low Voltage Gated Ca2+ Channel
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2020
Authors:
Ye, Yan-Song
;
Li, Wen-Yan
;
Du, Shu-Zong
;
Yang, Jian
;
Nian, Yin
;
Xu, Gang
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  |  
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  |  
View/Download:25/6
  |  
Submit date:2021/01/05
The discovery, design and synthesis of potent agonists of adenylyl cyclase type 2 by virtual screening combining biological evaluation
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020
Authors:
Xu, Guowei
;
Yang, Yaqing
;
Yang, Yanming
;
Song, Gao
;
Li, Shanshan
;
Zhang, Jiajun
;
Yang, Weimin
;
Wang, Liang-Liang
;
Weng, Zhiying
;
Zuo, Zhili
View
  |  
Adobe PDF(2526Kb)
  |  
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  |  
View/Download:32/3
  |  
Submit date:2021/01/05
Rhodamine B-based fluorescent probes for molecular mechanism study of the anti-influenza activity of pentacyclic triterpenes
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020
Authors:
Li, Man
;
Yuan, Lan
;
Chen, Yingying
;
Ma, Wenxiao
;
Ran, Fuxiang
;
Zhang, Lihe
;
Zhou, Demin
;
Xiao, Sulong
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  |  
Adobe PDF(2312Kb)
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  |  
View/Download:12/2
  |  
Submit date:2021/01/05
Design and synthesis of novel artemisinin hybrids with potent activities against human colorectal cancer cells in vitro and in vivo (vol 182, 111665, 2019)
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020
Authors:
Wang, Liang-Liang
;
Kong, Lingmei
;
Liu, Hui
;
Zhang, Yunqin
;
Zhang, Li
;
Liu, Xingyong
;
Yuan, Feng
;
Li, Yan
;
Zuo, Zhili
View
  |  
Adobe PDF(169Kb)
  |  
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  |  
View/Download:34/9
  |  
Submit date:2021/01/05
Design and synthesis of novel artemisinin derivatives with potent activities against colorectal cancer in vitro and in vivo
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 182, 页码: 10
Authors:
Wang, Liang-Liang
;
Kong, Lingmei
;
Liu, Hui
;
Zhang, Yunqin
;
Zhang, Li
;
Liu, Xingyong
;
Yuan, Feng
;
Li, Yan
;
Zuo, Zhili
Favorite
  |  
View/Download:49/0
  |  
Submit date:2020/03/02
Artemisinin
Quinazoline
Hybridization
Colorectal cancer
Chemotherapy
Synthesis and antitumor activity of novel steroidal imidazolium salt derivatives
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 168, 页码: 232-252
Authors:
Deng, Guogang
;
Zhou, Bei
;
Wang, Jing
;
Chen, Zhuo
;
Gong, Liang
;
Gong, Yaxiao
;
Wu, Dongmei
;
Li, Yan
;
Zhang, Hongbin
;
Yang, Xiaodong
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  |  
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View/Download:102/14
  |  
Submit date:2019/07/29
Diosgenin
Cholesterol
Dehydroepiandrosterone
Imidazolium salt
Antitumor activities
Structure-activity relationships
Synthesis and structure-activity relationship studies of water-soluble beta-cyclodextrin-glycyrrhetinic acid conjugates as potential anti-influenza virus agents
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 166, 页码: 328-338
Authors:
Liang, Shuobin
;
Li, Man
;
Yu, Xiaojuan
;
Jin, Hongwei
;
Zhang, Yongmin
;
Zhang, Lihe
;
Zhou, Demin
;
Xiao, Sulong
View
  |  
Adobe PDF(1284Kb)
  |  
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View/Download:144/9
  |  
Submit date:2019/04/15
Glycyrrhetinic acid
Cyclodextrin
Click reaction
Influenza virus
Inhibitors